Case 9- Thyroid dysfunction Flashcards
What are the 3 main functions of the thyroid gland?
- Regulates basal metabolic rate (BMR)
- Stimulates somatic and psychic growth
- Role in calcium metabolism (with parathyroid gland)
What is the functional unit of the thyroid?
Thyroid follicles
What type of cells are follicular cells?
Simple cuboidal epithelial cells
How is are T3 and T4 synthesised?
1: PV nucleus in hypothalamus releases TRH
2: acts on thyrotrophs in AP to release TSH
3: Stimulates follicular cells to release thyroglobulin
4: Iodide moves into the FC with Na+ and then via pendrin proteins
5: iodide is oxidised to iodine via thyroid peroxidase (TPO)
6: TPO catalyses the iodination of tyrosine AA in thyroglobulin -> T3 and T4
How are T3 and T4 isolated and transported?
1: After synthesis = endocytosis of thyroglobulin with T3 and T4
2: lyosozyme enzymes split the thyroglobulin colloid to isolate T3 and T4
3: liver produces thyroxine-binding globulin (TBG), which binds to T3 and T4 to transport them in blood
What are the full names of T3 and T4? Which is the active form?
T4 (thyroxine) and T3 (triodothyronine)
T3= active form
How does T4 get converted into T3?
Crosses over the lipid bilayer to enter the cell, then 5’ deiodinase (also known as type 1 selenodeiodinase [D1]), enzyme removes iodine off T4 –> T3
How does thyroid hormone increase basal metabolic rate?
Retinoic acid and T3 bind to a transcription factor, activating it so it can stimulate genes. Overall result = protein synthesis of Na/K+ ATPase pumps. These pumps utilise ATP therefore leads to decreased cellular ATP, increased O2 usage = metabolic rate increases.
How does thyroid hormone cause increased BP?
Effects the heart - increases B1 adrenergic receptors (R for Adr/NA) so contractility, SV and Q goes up, acts on SAN/AVN to increase B1aR’s too, so HR increases [overall increases BP]
How does thyroid hormone affect the CNS?
Increases dendrites, myelination, synapses
How is the HPA axis altered in depression?
- Increased corticotrophin-releasing hormone (CRH)
- Enlarged pituitary and/or adrenal
- Increased ACTH and/or cortisol during depressive periods
What is Cushing’s syndrome? What psychological symptoms may it present with?
Cortisol hypersecretion, often associated with depression and irritability. May also suffer:
- Fatigue
- Decreased libido
- Poor concentration
- Impaired memory and poor problem solving
What is Addison’s syndrome? What psychological symptoms may it present with?
Cortisol hyposecretion, often associated with lethargy and apathy. Other behaviours:
- Irritability
- Crying
- Insomnia/ impaired sleep
- Problems with memory and concentration
- Tachycardia
What are the differential diagnoses of Addison’s and Cushing’s syndrome?
Cushings - depression,
Addisons- anxiety, as the symptoms are non-specific and come and go (esp during periods of stress)
How can hyperthyroidism influence behavioural states?
Intense dysphoria, usually pronounced anxiety. May also include:
- Nervousness
- Emotional instability
- Restlessness
- Impaired concentration
- Insomnia and fatigue
How can hypothyroidism influence behavioural states?
Cognitive dysfunction = impaired memory, concentration, inattentiveness, slowness, poor problem solving
Mood= depressed mood, anxiety, irritability, confusion (if severe can = psychosis)
What is the 2-pattern response of stressors on endocrine response?
1: stress promotes adaptive changes in the endocrine system to help the person deal with the threat, i.e. mobilisation of fuel, increased resistance to infection
2: prolonged/ repeated stress= adaptive changes such as enlarged adrenal glands
What is an allostatic load? What can it lead to?
Cumulative burden of chronic stress and life events
Prolonged stress can lead to dysregulation of endocrine function.
What is thyrotoxicosis and what can it be caused by?
Excess circulating thyroid hormone. Causes:
- Pharmacological: i.e. taking too much thyroid hormone
- Transient: viral infection (e.g. coxsackie), inflammation of the thyroid (transient wave of overactivity then leads to underactivity)
What can cause hyperthyroidism?
- Graves disease
- Toxic nodule - single or multiple, benign follicular adenomas
- TSH-secreting pituitary adenoma: rare tumour secreting high TSH so T3/T4 are elevated. Doesnt respond to the negative feedback loops
- Pituitary thyroid hormone resistance syndrome: genetic mutations in beta gene, usually euthyroid but thyrotoxic symptoms
What are some symptoms of hyperthyroidism?
- Irritability, nervousness
- Hyperactivity
- Heat intolerance & sweating
- Weight loss
- Increased appetite
- Dyspnoea
- Palpitations
- Diarrhoea
- Hair loss
How does hyperthyroidism lead to heat intolerance and sweating?
Thyroid hormone causes vasodilation of blood vessels to lose excess heat from the high metabolism, also Adr/NA stimulate sweat glands to produce more sweat for evaporative cooling
How does hyperthyroidism lead to dyspnoea?
tracheal compression from a large goitre
What finding may be present in a patient with hyperthyroidism for:
- Percussion
- Auscultation
- Percussion of the sternum may = dull, indicates the thyroid may have extended below and behind (retrosternal goitre)
- Auscultation: bruit (constant noise), i.e. increased BF to the thyroid gland
What might the results of thyroid function tests be for a patient with hyperthyroidism? i.e. overt primary, subclinical primary, and secondary
Overt = T3 and T4 high, TSH low
Subclinical = T3 and T4 normal, TSH low - indicates the thyroid hormones have been compensated for
Secondary = T3 and T4 high, TSH high
What is a differential for hyperthyroidism? What would indicate this?
Grave’s disease = thyroid auto-antibodies (for TSH receptor), positive clinical picture and TFTs, positive family history
What 3 investigations may be done if you suspect hyperthyroidism? What might they show?
- Ultrasound of the neck: may show increased inflammation or increased vasculature (accounting for the bruit), can show if there’s nodules or not
- Radioiodine uptake scan: also shows if there’s nodules
- 24hr urinary iodine excretion: can confirm if its due to excessive iodine intake
What are some risk factors for Grave’s disease?
- Female sex: 10x more likely
- Family history
- Smoking
- Low iodine intake: may cause MNG or SNG
- Autoimmune disease
- People with psychiatric disorders?
Whilst waiting for an endocrinologist’s referral, what may you prescribe to a patient with suspected hyperthyroidism?
Beta blockers for adrenergic symptoms (i.e. palpitations, tremor, tachycardia, anxiety)
What would you treat hyperthyroidism with?
Anti-thyroid drugs: thionamides, such as carbimazole (1st line) or propylthioruacil (2nd line)
What is carbimazole contraindicated in?
Pregnancy - use PTU
What is the MOA of thionamides?
Act as a preferred substrate for iodination by TPO - the key step in thyroid hormone production
After euthyroidism is achieved, what two drug regimens may be used?
- Titration-block regimen: dose is adjusted depending on free T4 levels - titrate to lowest dose possible to maintain euthyroid state
- Block and replace: give thionamide and then when free T4 is normal, add levothyroxine
What is radioactive iodine treatment?
What patients might this be used for?
Induces damage of DNA leading to death of thyroid cells = decreases thyroid function and/or reduction in thyroid size.
- First line definitive treatment for Grave’s and toxic MNG
Who is radioactive iodine treatment contraindicated in?
People with Grave’s and has active or severe orbitopathy
Patients with Grave’s but are pregnant
What are some complications of untreated hyperthyroidism?
- Graves orbitopathy
- Thyrotoxic crisis (thyroid storm) - leads to fever, tachycardia, hyperthermia
- Compression symptoms - dysphagia or breathlessness
- Cardiac problems
- Osteoporosis
- Psychosis
Where is hyperthyroidism more prevalent?
In iodine-deficient areas, such as Denmark
What is Grave’s disease?
Systemic autoimmune disorder - characterised by TSH-receptor auto- antibodies, leading to thyroid hyperplasia and excessive secretion of thyroid hormone. Has waves of inflammatory stimulation
Who is at increased risk for Grave’s disease?
- Women
- People with a personal or family history of autoimmune disorders (i.e. T1DM, Addison’s vitiligo, pernicious anaemia, myasthenia gravis, coeliac disease)
Other than the typical hyperthyroidism symptoms, what signs may be present in Graves disease?
- Orbitopathy: bulging of the eyes forwards
- Pretibial myoxedema: thickening of the skin
- Vitiligo: white patches
What is Grave’s orbitopathy?
Inflammation of extra-ocular muscles, causing increased retro-orbital pressure leading to proptosis = eye(s) pushed forward.