Case 3 - Renal replacement therapy Flashcards

1
Q

3 types of RRT

A
  • Haemodialysis
  • Peritoneal dialysis
  • Transplantation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the 3 types of peritoneal dialysis?

A
  • Automated PD- automated cycler machine at night, 10-12L exchanged over 8-10hrs
  • Continious ambulatory PD - 4-5 dialysis exchanges per day, regular intervals with a long overnight swell
  • Assisted automated PD - HCA visits pts home to help with setting up
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is peritoneal dialysis?

A
  • Home based therapy
  • Uses patients peritoneal membrane as dialysis membrane
  • Solutes move from patients blood across peritoneal membrane down conc gradient to dialysate fluid
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is osmotic gradient created in peritoneal dialysis?

A
  • High concentration of glucose (ocassionally amino acids or glucose polymer solutions are used) in dialysate fluid - removes water from patient
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What moves across from blood into dialysate fluid in peritoneal dialysis?

A
  • Urea
  • Electrolytes
  • Creatinine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Advantages of peritoneal dialysis

A
  • Quality of life good
  • Excellent first choice when starting dialysis - esp when have residual renal function
  • Regimes are much more individualised than HD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Disadvantages of PD

A
  • Need to be able to manage technical aspects of dialysis
  • Unsuitable if have stoma/pervious surgery
  • Risk of infection eg PD peritonitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Complications of PD

A
  • Drainge problems
  • Malposition
  • Leaks
  • Herniae
  • Hydrothorax (pleural effusion)
  • Long term use –> encapsulating peritoneal sclerosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When is haemodialysis used?

A
  • AKI
  • ESRF

So can be temporary or permanent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How does haemodialysis work?

A
  • Dialysis machine pumps blood from patient through disposable tubing
  • Through dialyser/artifical kidney
  • Back to patient
  • Waste solute, salt and excess fluid is removed from blood as it passes through dialyser
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Advantages of haemodialysis

A
  • Efficient
  • Unit based - support from staff
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Disadvantages of haemodialysis

A
  • Access needs to be secured for dialysis
    *
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Complications of haemodialysis

A
  • Infection/bacteraemia
  • Haemodynamic instability
  • Reactions to dialysers
  • Haematomas/risk of bleeding
  • Muscle cramps
  • Anaemia due to clotted lines/haemolysis
  • AVF steal syndrome
  • SVCO from central lines
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

3 types of haemodialyssi

A
  • Home HD - offer training at home for more frequent dialysis
  • Nocturnal - overnight slow and long
  • CRRT - continious renal replacement therapy mainly used in acute setting eg ITU/HDU
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Who is renal transplant used for?

A

Treatment of choice for most patients with ESRF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Where does renal transplant come from?

A
  • Live related/non related
  • Deceased donor
17
Q

Advantages of transplant

A
  • Near normal lifestyle
  • Better mortality and morbidity
18
Q

Disadvantages of transplant

A
  • Criteria to meet suitability for operation
  • Compliance with lifelong medication
  • Risk of rejection
  • Risk of maliganncies
  • Risk of infection
  • Long waiting times for cadaveric organ
19
Q

How do we make the decision for renal replacement therapy?

A
  • Discuss with patient and family
  • Multiple clinic visits and after patient is fully informed of risks and benefits of each mode
20
Q

Who does WHO suggest is not suitable for any RRT?

A
  • Age >80 OR
  • WHO perfomance score of 3 or more - offers no survival benefit
  • Often unsuitable for or choose to not have invasive RR therapy so do conservative management instead
21
Q

Conservative management of ESRF

A
  • Symptom control - enhance QOL
  • Respect patinets preferrred place of care
  • Advanced care plan
  • MDT approach
  • Support system for patient and family
22
Q

Principles of managing CKD end stage mineral bone disease

A
  • Decreased phosphorus intake - high in processed foods
  • Calcitriol - active vitamin D, decreases PTH
  • Calcium and vitamin D supplements
  • Calcimimentics - decrease PTH
  • Phosphate binders
  • Parathyroidectomy if not managed with medication
23
Q

Managing anaemia in CKD?

A
  • Treat iron deficiency - oral if not on HD, if are = IV infusion
  • IV or subcut erythropoesis stimulating agents eg epoetin alpha
24
Q

Pros vs cons of live organ vs deceased donor

A

Pros live:
* Decreased risk rejection
* Shorter wait
* Planned surgery
* Lasts longer
* Can usually have before starting dialysis

Cons:
* Complex chain sometimes - fall through?
* Find match

25
Q

Immunosupressive drugs given following kidney transplant

A
  • Mycophenolate mofetil
  • Tacrolimus
  • Cyclosporin
  • Azathioprine
  • Prednisolone