Cartilage tissue function Flashcards

1
Q

What are the main functions of cartilage tissue?

A

Protection and cushioning of bones

Provides a smooth gliding surface within joints

Supports flexible tissue structures

Provides a transition tissue tendons/ligaments and bones

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2
Q

What do cartilage protect bones from?

A

Cartilage protect bones from compressive joint loads

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3
Q

What features do cartilage have that provide it with the ability to support flexible structures?

A

Cartilage is a highly deformable and compressible elastic connective tissue

Allows it to support flexible tissue structures

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4
Q

What is an enthesis?

A

Connective tissue between bone and tendon/ligament structures

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5
Q

Where are synovial joints found?

A

Covering the articulating joints

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6
Q

What role does cartilage play in the funcitoning of synovial joints?

A

Cartilage tissue is central to the functioning of synovial joints

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7
Q

What are the 3 types of cartilage found in the adult body?

A

Fibrocartilage

Hyaline cartilage

Elastic cartilage

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8
Q

Where is fibrocartilage found?

A

Intervertebral discs

Joint capsules

Ligaments

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9
Q

Features of fibrocartilage

A

Strongest kind of cartilage

Alternating layers of hyaline cartilage matrix and thick layers of dense collagen

No perichondrium

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10
Q

How are the collagen fibres oriented in fibrocartilage?

A

Oritented in the direction of functional stresses

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11
Q

Role of fibrocartilage

A

Transitional layer between hyaline cartilahe and tendon/ligament

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12
Q

Where is hyaline cartilage found?

A

Ribs

Nose

Larynx

Trachea

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13
Q

Features of hyaline cartilage

A

Most abundant form

Weakest

Glassy appearance

Contains dispersed, strengtening type II collagen

Has perichondrium

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14
Q

Role of hyaline cartilage

A

Part of the endochondral ossification process

Acts as a model anlagen

Precursor of bone

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15
Q

Structural features of elastic cartilage

A

Chondrocytes found in threadlike network of elastic fibres within the matrix

Has a perichondrium

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16
Q

Role of elastic cartilage

A

Provides strength and elasticity

Maintains shape of structures

17
Q

Example of a structure that the elastic cartilage maintains the shape of

A

Ear

18
Q

What makes cartilgae disntict from other tissue types?

A

Has only 1 cell type = chondrocyte

Contains highly specific and abundant ECM

Lacks blood vessels and innervation

Very limited regenerative capacity

19
Q

Are chondrocytes found in high numbers in the cartilage?

A

NO

Chondrocytes are found in very low numbers relative to the matrix volume

20
Q

Why is cartilage described as hydrodynamic?

A

Cartiage has high mechanical resiliency to compressive loading

21
Q

How do cartilage receive nutrients since the tissue has no blood supply?

A

Receives nutrients via mass exchange

Diffusion

22
Q

Why is cartilage described as a bradytrophic tissue?

A

Cartilage has a slow metabolism

23
Q

What is the half life of cartilage?

A

Half life is estimated as 117 years

Built for life - does not undergo extensive remodelling like bone

24
Q

What percentage of the ECM is water in hyaline cartilage?

A

75%

25
Q

What are the 4 structurally distinct zones of the hyaline cartilage ECM called?

A

Articular surface (10-20% of volume)

Middle zone (40-60% if volume)

Deep zone (30-40% of volume)

Calcified zone

26
Q

What is the role of the articular surface of the hyaline cartilage?

A

Provides smooth glinding surface for joints

Supported by 2-3 layers of chondrocytes

27
Q

What is the largest zone of the hyaline cartilage?

A

Middle zone

28
Q

Structure of the middle zone

A

Chondrocytes and collagen fibers in cartilage surface orientation

29
Q

Structure of the deep zone

A

Type II Collagen fibers in perpendicular orientation to joint
Highest proteoglycan concentration

Round chondrocytes in columnar orientation

30
Q

Role of the calcified zone

A

Forms the transition tissue between cartilage and subchondral bone

31
Q

What separates the deep zone from the calcified zone?

A

Tidemark

Made of parallel collagen type I fibers