Cartilage layers Flashcards
Lubricin, tangential orientation, progenitor/stem cells, highest collagen concentration, opposes shear
Superficial (gliding) zone
Type VI collagen, oblique orientation, opposes compression
Transitional (middle) zone
Highest proteoglycans, lowest water, high Aggrecan, low collagen, vertical orientation
Deep (radial) zone
Type X collagen, hypertrophic chondrocytes (low activity)
Calcified zone
Increase with aging
Keratan sulfate, chrondrocyte size, modulus of elasticity
Decrease with aging
Water, proteoglycans, number of chondrocytes, chondroitin
Increase with OA
Water, chondroitin
Decrease with OA
Proteoglycans, keratan sulfate, modulus of elasticity
Collagen types in annulus and in nucleus of disc
I and II