Cartilage and bone Flashcards
What does a large ratio of GAGs (glycosaminoglycans) and type II collagen in the ECM permit?
diffusion of substances between blood vessels in surrounding connective tissues and
chondrocytes in the matrix
What does the perichondrium do?
a sheath of dense (irregular) connective tissue that surrounds cartilage
what contains blood vessels serving the cartilage and a small neural component
Perichondrium
What is the most common type of cartilage
Hyaline
What is distinguished by a homogeneous amorphous extra cellular matrix
Hyaline cartilage
Where are chondrocytes found in hyaline cartilage
found within lacunae (spaces within the
ECM)
type II collagen makes up what
bulk of collagen fibers
what type of collage consists in the perichondrium
type i collagen
outer layer of the perichondrium contains what?
fibrous layer – type I collagen and fibroblasts
The inner perichondrium layer has a _____ layer that is filled with what?
chondrogenic layer
– type I collagen and chondroblasts
What is interstitial growth
growth from within the
cartilage proper
How are elastic cartilage distinguished
elastic fibers
what is Fibrocartilage a a combination of?
dense connective tissue and hyaline cartilage
What type oof cartilage is located where resistance to both compression and shearing forces is required of the
tissue:
Fibrocartilage
What are Osteoids
uncalcified and unmineralized
______ are secreted with initial collagen rich materials
Osteoid
______ represents appositional growth which is completed with subsequent calcification (no
interstitial growth
Osteoid
Osteoclast rest directly on bone surface where resorption is occurring within enzymatically etched
depressions, or lay within ____
cavities called Howship’s lacunae
What fibers are bound bone to matrix
Sharpley’s fiber
What fibers are are bundles of type 1 collagen fibers which penetrate the boone matrix
Sharpley’s fibers
lamellae arranged in parallel sheets or concentrically around a central canal called what
Haversian canal
What. do Haversian canals contain
blood vessels and nevers, lined by endosteum
osteonal (Haversian) canals communicate through transverse ____________ carrying blood vessels and nerves
Volkmann canals
(perforating canals)
What is a wovern bone
immature bone, primary bone
what bone is initially formed in skeleton of developing fetus
woven bone
What type of bone is a non lamellar and has cells randomly arranged
Woven bone
What are examples of a trabecular bone, spongy bone
Cancellous bone (type of lamellar bone)
What type of lamellar bone is sponge-like meshwork consisting of trabeculae
Cancellous bone
What type of bone ossification forms most bone and hyaline cartilage models serves as a precursor
Endochondral ossification
in diaphysis of fetal long bones- chondrocytes die
after enclosure of cartilage within a collar of woven bone, creating an initial cavity
entered by periosteal osteoblasts and blood vessels
Primary ossification centers
develop within the epiphysis with cartilage of the
epiphyseal growth plate- separates the epiphyseal and diaphyseal cavities of
bone; responsible for maintaining growth in length (bone lengthening)
Secondary ossification centers
