Caring for pts on bloodthinners Flashcards
T/F: Patient’s on Oral anticoagulant/antiplatelet treatment are currently not recommended to
discontinue their medication prior to minor oral surgery procedures as this increases their risk
of developing a thrombo-embolic episode.
True
an acetylated salicylate (acetylsalicylic acid), is classified among the nonsteroidal
antiinflammatory drugs (NSAIDs).
These agents reduce the signs and symptoms of inflammation and exhibit a broad range of
pharmacologic activities, including analgesic, antipyretic, and antiplatelet properties.
Aspirin,
irreversibly inactivates cyclooxygenase
* Platelets cannot synthesize protein, so cannot make thromboxane until new platelets
are made
* The lack of thromboxane markedly diminishes platelet activation and aggregation
* OTHER NSAIDs ARE NOT IRREVERSIBLE!!!!
* They inhibit cyclooxygenase but are effective only while drug is present
Aspirin
Does low dose aspirin or normal does 325 mg show more blood thinnings via inhibiting generation of thromboxane A2?
Low dose aspirin
is used to prevent M.I and Cerebro-vascular accidents in persons with cardiac
disease(recent M.I), recent stroke or those with peripheral vascular disease.
* works by blocking platelets from sticking together and prevents them from forming
harmful clots.
Plavix
Do ASA and plavix work on clotting factors or platelets?
Platelets
therapy is used in several conditions to prevent or treat thromboembolism.
* The patients with the following medical conditions take oral anticoagulants.
* Prosthetic heart valves
* Atrial fibrillation
* Valvular heart disease
* Previous deep vein thrombosis
* Pulmonary embolism
* Congestive cardiomyopathy
- Anticoagulation
Are pts worse off if they are taking anticoagulants or antiplatelets?
Anticoagulants
is a vitamin K antagonist.
* It affects clotting factors II, VII, IX, X and makes them biologically inactive.
* It affects factor VII first and this increases the prothrombin time (PT).
* It then affects factors IX, X and II and thereby increases the partial thromboplastin time (PTT) .
Warfarin
What are the vitamin K dependent clotting factors?
2, 7, 9, 10
The coagulation status of a patient taking Warfarin assessed with an International
Normalized Ratio (INR) test.
Is INR based on PT or PTT
PT
Does pradaxa require frequent monitoring?
No only inhibits one factor
______ is an orally-administered, selective, reversible, direct inhibitor of activated
factor X (factor Xa), and is currently indicated for prophylaxis of venous thromboembolism
(VTE) in adults after hip or knee replacement surgery.
Rivaroxaban (xarelto)
______ to reduce the stroke and systemic embolization risk in patients with non-valvular
atrial fibrillation
* Recent studies have shown that dabigatran, given at a fixed dose (owing to predictable
pharmacokinetics) does not require monitoring and is as effective as warfarin in preventing
embolic events in patients with atrial fibrillation.
dabigatran (pradaxa)
