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Cardio > CardPharm > Flashcards

CardPharm Flashcards

1
Q

HF Tx

A

Beta blockers, ACEi, ARBs + neprilysin inhib : Sacubitril-Valsartan

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2
Q

Sacubitril

A

Neprilysin inhib + AT II blocker

  • Neprilysin : metalloprotease breaks down ANP n BNP
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3
Q

Antianginal drugs causing inc coronary vasodilation

A
  1. Dihydropiridines
  2. Non-DHP
  3. Nitrates
  4. Fenoldopam
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4
Q

Antianginal drugs dec HR

A
  1. Beta-blockers

2. Non-DHP

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5
Q

Antianginal drugs dec Preload

A

Venodilation

  1. Nitrates/ Nitroglycerin
  2. Nitroprusside (a+v)
  3. Nesiritide (AL+PL)
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6
Q

Drugs dec Afterload

A

Arterial dilation

  1. DHP: Amlodipine , Nifedipine
  2. Nitroprusside (a+v)
  3. Hydralazine
  4. Milrinone
  5. Nesiritide (AL+PL)
  6. Beta-blockers
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7
Q

Nitrates/Nitroglycerin MOA:

SE:

A

Direct smooth muscle relaxation:

  1. VENOdilation of periph (= Inc peripheral venous capacitance)
  2. Dec preload (dec LVEDV+LVEDP. dec LV systolic wall stress + dec myocardial O2 demand - inc exercise tolerance :: relieves angina )
  3. Mod dec in AL, d/t dec SBP
  4. Mild coronary artery dilation

— headache, flushing, hypotension, reflex tachycardia (d/t dec BP : prevent by co-adm beta-blockers)
— rapid tolerance to Nitrates : relieved by nitrate-free pd each night

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8
Q

Tx Septic shock

A

Pressor drugs : Phenylephrine

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9
Q

Drug causing peripheral vasoconstriction, inc SVR, inc BP

A

Pressor: Phenylephrine

Tx: Septic shock

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10
Q

DI AV conduction delay

A

Antianginals:

  1. CCBs
  2. Beta-blockers: Metoprolol, Propranolol
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11
Q

Atrial rhythm control maintained by which anti arrhythmics?

A

Class I + Class III

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12
Q

Ventricular rate control maintained by which anti arrhythmics?

A

Class II + Class IV

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13
Q

Which anti arrhythmics slow AP conduction velocity?

A

Class IA, IC

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14
Q

Which anti arrhythmics shorten APD?

A

Class IB

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15
Q

Which anti arrhythmics prolong APD?

A

Class IA, III

— QT prolongation

Tx: AFib / AFlutter

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16
Q

Which anti arrhythmics slow sinus node discharge ?

A

Class II + IV

— also slow AN nodal conduction + prolong refractoriness

17
Q

Cardio selective beta blockers

A
  1. Atenolol, Acebutol
  2. Bisoprolol, Butaxalol
  3. Esmolol
  4. Metoprolol
  5. Nebivolol
18
Q

CI beta-blockers

A
  1. Bradycardia
  2. Heart block
  3. Hypotension
  4. HF d/t Pulm edema
19
Q

Drugs dec MVO2

A
  1. Beta-blockers

2. Nitrates

20
Q

Drug used on cardiac stress test.

A

Regadenoson
A2 adenosine R agonist
- coronary vasodilation

21
Q

Drug blocking both K+ n L-Ca ch?

A
  1. Adenosine
  2. ACh
  • slow sinus rate
  • inc AV conduction delay

Tx: PSVT

22
Q

Drugs used for pharm stress test w coronary vasodilators

A
  1. Dipyridamole

2. Regadenoson

23
Q

Unstable angina/ NSTEMI Tx

A
  1. Anticoagulants: Heparin
  2. Anti-platelet: Aspirin
  3. ADP R inhib: Clopidogrel
  4. Beta-blockers
  5. ACEi
  6. Statins

Sx control: Nitroglycerin + Morohine

24
Q

STEMI Tx

A

NSTEMI Tx + reperfusion thx

Percutaneous coronary intervention (PCI/PCTA. angioplasty w stent)&raquo_space; fibrinolysis

25
Q

Drugs causing arteriolar dilation

A
  1. Hydralazine
26
Q

Drugs causing venodilation

A

Nitrates

27
Q

NS vasodilator drugs

A
  1. Nitroprusside

2. Sacubitril

28
Q

Drugs ↓↓ LDL

A 
via inc LDL upreg: 
From most to least 
1. Statins (most)
2.PCSK9 inhib: Alirocumab 
3. Bile resins 
4. Ezetimibe
5. Niacin
29
Q

Drugs ↑↑ HDL:

A
  1. Niacin (most)
  2. Fibrates
  3. Fish oil
30
Q

SE luminous phenomena

A

Ivrabradine

Prolongs phase IV by inhibiting funny Na ch

31
Q

MOA of Digoxin used for ventricular rate control in AFib w RVR?

A

Dec AV conduction by inc PANS tone

32
Q

DI dec myocardial contractility w/out myocardial destruction seen w?

A

Trastuzumab

33
Q

Anti HTN causing initial inc in creatinine

A

ACEi : d/t dec initial GFR

34
Q

+inotrope w minimal effect on vessels

A

Digoxin

Inc contractility

Cardio (8 decks)

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