Cardiovascular System II - ECG Flashcards
What is an electrocardiogram (ECG
Measured by electrodes put on skin pick up electrical fields from signals conducted in heart
Describe an ECG
Body fluids are saline, conduct electrical signals well, EKGs recorded from limb leads/chest leads
What do different leads emphasise?
Different aspects of electrical signals
What are the different parts of a heartbeat shown on an ECG?
P wave, PR interva;, QRS complex, S-T segment, T-wave, QT interval
What is the P wave?
Atrial depolarisation
What is the PR interval?
Time from onset of atrial activation to onset of ventricular activation
What is the QRS complex?
Ventricular depolarisation
What is the S-T segment?
Isoelectric, Ventricles before repolarisarion
What is the T-wave?
Ventricular repolarisation
What is the OT interval?
Duration of ventricular activation and recovery
How is the paper divided on an ECG sheet?
Paper divided into small 1mm and large 5mm squares
How many smalls squares in 1 large square?
1 large square = 5 small squares
What length per time does the paper at?
25mm per second
Describe the time calculated from small and large squares
1 small square (1/25) = 0.04sec
1 large square = ⅕ = 0.2 sec
5 large squares = 1 sec
300 large squares = 1 min
What are the steps to calculating heart rate from an ECG sheet?
Count no. large squares btw consecutive beats eg R-R interval
Divide 300 by n.o of large squares in R-R interval
Eg large squares btw 2 beats = 4, 300 large squares = 1 min, time for 1 beat = 4 squares, N.o of beats per min = 300/4
What is an arrythmia?
Abnormalities in heart rhythm
What are the 2 causes of arrythmias?
Malfunction of the conductive system
Abnormal impulse generation (ectopic beats)
Describe malfunction of the conductive system
Partial damage to AV node, lead to heart block causing more than one P wave in each QRS-T complex
Describe abnormal impulse generation
Originate in atria/ventricle in absence of nodal damage/initiate extra systoles
Describe ectopic beats
Loss or addition of a beat
If many ectopic foli form, discharge asynchronously means cardiac tissue is fibrillating - Heart may not pump blood when this occurs
Describe the difference between atrial and ventricular fibrillation
Atrial fib - QRS complex can form but superimposed on irregular baseline with no clear P waves
Ventricular fib - No QRS-T waves, causing no cardiac output result in death
What is tachycardia?
Heart rate over 100 beats/min
What are the causes and other types of tachycardia?
Benign factors (very dangerous) Atrial fibrillation, atrial flutter, atrial tachycardia, ventricular tachycardia
What is bradycardia?
Heart rate under 60 beats/min
Describe bradycardia
Leads to fatigue, weakness
Atrial bradycardia caused by vagal nerve stimulation, AV node, absence of electrical impulse from sinus node
What is a heart block?
Blockage of part of the electrical system of heart
What is caused (symptoms) and what can a heart block lead to?
Lightheadedness, syncope (fainting), palpitations (as opposed to coronary heart disease (CAD) - Blood vessels of heart)
CAD leads to angina/MI
What are the 5 types of blood vessels?
Arteries, Arterioles, Capillaries, Venules, Veins
What are the 3 layers of a muscular arteriole?
Tunica intima (innermost layer) Tunica media (middle layer) Tunica adventitia (outer layer)
Describe tunica intima
Single monolayer of endothelial cells on thin layer of connective tissue
Endothelial cells from main barrier to other circulating blood factors eg plasma proteins
Endothelium secrete vasoactive substances which contribute in regulating vascular tone (nitric oxide, prostacyclin)
Describe tunica media
Consists of spindle-shaped smooth muscle cells embedded in matrix of elastin/collagen
Provides mechanical strength, contractile power for blood vessel (contraction and dilation)
Describe tunica adventitia
Connective tissue sheath, no distinct outer border, binds to vessel loosely in place
Consists mostly of fibroblasts and nerve endings
Describe elastic arteries
Conducting vessels - Diameter 1-2cm in man
Name examples of elastic arteries and what are they characterised by?
Pulmonary artery, Aorta, Major aortic branches (eg iliac arteries)
Distensible walls - High elastin in medial layer
What does elastin allow?
Vessels to expand/receive stroke volume during ventricular ejection (and recoil during diastole)
Why is collagen within the medial layer?
Provides rigid support preventing vessels from over-distending
Describe the classification of arterioles (resistance arteries)
Diameter (20-100M), relatively thick walls (20-30M)
Provide main resistance to blood flow - High resistance due to narrow lumen
Regulate blood flow locally by inc/dec flow
Describe the classification of capillaries (exchange vessels)
Diameter (6-10M)
Single layer of endothelial cells
Thickness (0.2-1M) facilitates rapid transfer of metabolites between blood/tissue
Describe the classification of capacitance vessels (venules and veins)
Thinner walls than arteries
Allows easy distension/collapse - Act as reservoir of blood
Many veins innervated by vasoconstrictor nerve fibres - Allows volume of blood in vessels to be actively controlled
Define blood pressure
Pressure exerted by circulating blood upon walls of blood vessels
Describe blood pressure
Systemic arterial pressure measured on upper arm - Measure of pressure in brachial artery
How is blood pressure expressed?
As systolic pressure over diastolic pressure (mmHg) eg 120/80
Describe pressure gradient in blood vessels
Mean systemic blood pressure = 93mmHg in arteries to 10mmHg in vena cava
Velocity of flow depends on total cross sectional area
Flow is slowest in caps, fastest in aortic major arteries
Why does pressure never reach zero?
Arteries aren’t completely empty of blood
What is the equation for pulse pressure?
PP = SP - DP SP = Systolic pressure DP = Diastolic pressure
What is the magnitude of pulse pressure due to?
Stroke volume, Speed of ejection from heart, Arterial compliance
Describe pulse pressure
Average - 30-40mmHg - Incr with exercise due to inc stroke volume, Lowered by low stroke volume (eg trauma, blood loss), Long term inc due to aortic stiffening
Define mean arterial blood pressure
Average bp over entire body
Average arterial pressure during single cardiac cycle
Equation for mean arterial blood pressure: MAP = (CO x SVR) + CVP
What do they mean?
CO = Cardiac output SVR = Systemic vascular resistance CVP = Central venous pressure