Cardiovascular System - Finals Paper One Flashcards
What screening is used in abdominal aortic aneurysm?
Single abdominal ultrasound scan for 65 year old males
What is the next step in those with an abdominal aorta width <3cm?
No further action
What is the next step in those with an abdominal aorta width 3cm - 4.4cm?
Rescan every 12 months
What is the next step in those with an abdominal aorta width 4.5cm - 5.4cm?
Rescan every 3 months
What is the next step in those with an abdominal aorta width >5.5cm?
2 week referral to vascular surgery
What are the three criteria for 2 week referral for abdominal aorta surgery?
Symptomatic
Aortic diameter > 5.5cm
Rapidly enalrging > 1cm/yeat
What is the first line management option of unruputered abdominal aortic aneurysms?
Elective endovascular repair
What is the next step in those with ruptured abdominal aortic aneurysms?
Immediate vascular review
What is the first line management option in those who are haemodynamically stable with a ruptured abdominal aortic aneurysm?
CT Scan
What is the first line management option in those who are haemodynamically unstable with a ruptured abdominal aortic aneurysm?
Emergency Surgery
In which three patient groups does acute coronary syndrome present atypically?
Elderly
Diabetic
Female
Which ECG leads demonstrate changes when acute coronary syndrome develops in the left anterior descending artery/anteroseptal region?
V1 - V4
Which ECG leads demonstrate changes when acute coronary syndrome develops in the right coronary artery/inferior region?
II
III
aVF
Which ECG leads demonstrate changes when acute coronary syndrome develops in the left anterior descending artery/anterolateral region?
V1 - V6
aVL
Which ECG leads demonstrate changes when acute coronary syndrome develops in the left circumflex artery/lateral region?
I
aVL
V5 - V6
Which ECG leads demonstrate changes when acute coronary syndrome develops in the posterior region?
V1 - V3
Which ECG leads demonstrate changes when acute coronary syndrome develops in the posterior region?
V1 - V3
What are the four ECG criteria for a diagnosis of STEMI?
Acute coronary syndrome features > 20 mins with persistent ECG features in > 2 contiguous leads of…
- 2.5mm ST elevation in leads V2-V3 in men < 40 years old
- > 2mm ST elevation in leads V2-V3 in men > 40 years old
- 1.5mm ST elevation in V2-V3 in women
AND
1mm ST elevation in other leads
AND
New left bundle branch block
What are the five ECG features of posterior myocardial infarctions?
ST Depression
Tall, Broad R Waves
R Waves in V2
Upright T Waves
Q Waves In V7 - V9
What is the initial management of acute coronary syndrome?
Morphine
Oxygen < 92%
Nitrates
Aspirin 300mg
When should we be cautious about administering nitrates in acute coronary syndrome?
Hypotension
When is percutanous coronary intervention used to manage STEMIs?
When individuals present within12 hours of clinical feature of onset AND within 120 minutes of the time when fibronlysis could have been given
When individuals present after 12 hours of clinical features with evidence of ongoing ischaemia
Which antiplatelet should be administered, in addition to aspirin, prior to STEMI percutaneous coronary intervention - in those not taking an oral anticoagulant?
Prasugrel
Which antiplatelet should be administered, in addition to aspirin, prior to STEMI percutaneous coronary intervention - in those taking an oral anticoagulant?
Clopidogrel
Which access artery is preferred in percutaneous coronary intervention?
Radial
Which drug therapy should be administered during STEMI percutaneous coronary intervention - with radial access?
Unfractioned heparin with bailout glycoprotein IIb/IIIa inhibitor
Which drug therapy should be administered during STEMI percutaneous coronary intervention - with femoral access?
Bivalirudin with bailout glycoprotein IIb/IIIa inhibitor
Which stent types are used in percutaneous coronary intervention?
Drug eluting stents
What should be conducted when individuals are haemodynamically unstable or experience pain post percutaneous coronary intervention?
Urgent CABG Surgery
When is fibronlysis used to manage STEMIs?
When individuals present within 12 hours of clinical feature onset, however percutaenous coronary intervention cannot be delivered within 120 minutes
What investigation is conducted following fibrinolysis? When? Why?
ECG Scan
60 - 90 minutes
In order to determine whether percutaneous coronary intervention is required
Which antithrombin is used to manage NSTEMIs? What is the contraindication?
Fondapurinax
High Bleeding Risk
What risk assessment system is used to determine management of NSTEMIs?
GRACE score
What is the management option of NSTEMIs in those who are clinically unstable?
Immediate coronary angiography
What is the management option of NSTEMIs in those who with a GRACE score > 3%?
Percutaneous coronary intervention within 72 hours
Which antiplatelet should be administered, in addition to aspirin, prior to NSTEMI percutaneous coronary intervention - in those not taking an oral anticoagulant?
Prasugrel
OR
Tricagrelor
Which drug therapy should be administered during NSTEMI percutaneous coronary intervention?
Unfractioned Heparin
Which antiplatelet should be administered, in addition to aspirin, prior to NSTEMI percutaneous coronary intervention - in those taking an oral anticoagulant?
Clopidogrel
Which antiplatelet should be administered, in addition to aspirin, when NSTEMIs are managed conservatively - in those with a low bleeding risk?
Ticagrelor
Which antiplatelet should be administered, in addition to aspirin, when NSTEMIs are managed conservatively - in those with a high bleeding risk?
Clopidogrel
What is the red blood transfusion threshold in those with acute coronary syndrome?
< 80g/L
What is a poor prognostic factor in acute coronary syndrome?
Cardiogenic Shock
What are the four secondary prevention pharmacological management options of acute coronary syndrome?
Dual Antiplatelet Therapy
ACE Inhibitor
Beta-Blocker
Statin
What atorvastatin dose is recommended in secondary prevention?
80mg once daily
What advice is given in regards to driving following myocardial infarction?
They cannot drive for a period of four weeks
What is the most common cause of death folllowing myocardial infarctions?
Ventricular Fibrillation
What arythmia can occur in inferior myocardial infarctions?
Arterioventricular Block (Bradyarrythmias)
When does Dressler’s syndrome tend to occur > myocardial infarction?
2 - 6 weeks > myocardial infarctions
What are the three clincical features of Dressler’s syndrome?
Fever
Pleuritic Chest Pain
Pericardial Effusion
What blood test result indicates Dressler’s syndrome?
Increased ESR Levels
What is the management option of Dressler’s syndrome?
NSAIDs
When does left ventricular aneurysm tend to occur > myocardial infarction?
4 weeks > myocardial infarction
When does left ventricular aneurysm tend to occur > myocardial infarction?
4 weeks > myocardial infarction
What are the three clinical features of left ventricular aneurysm?
Bibasal Crackles
3rd Heart Sound
4th Heart Sound
What are the two ECG features of left ventricular aneurysm?
ST Elevation
Q Waves
When does left ventricular free wall rupture tend to occur?
1 - 2 weeks > myocardial infarction
What is the clinical feature of left ventricular free wall rupture > myocardial infarction?
Acute heart failure secondary to cardiac tamponade
What are the three clinical features of cardiac tamponade?
Increased JVP
Pulsus Paradoxus
Diminshed Heart Sounds
When does ventricular septal defect tend to occur > myocardial infarction?
1 week > myocardial infarction
What is the clinical feature of ventricular septal defect > myocardial infarction?
Acute heart failure with pansystolic murmur
What is the invesigation used to diagnose ventricular septal defect?
ECHO Scan
How is acute mitral regurgitation associated with myocardial infarctions?
This is due to ischaemia or rupture of the papillary muscle
What are the three clinical features of acute mitral regurgitation?
Pulmonary Oedema
Hypotension
Pansystolic Murmur Radiates To Axilla
What investigation is used to in new-onset acute heart failure?
ECHO Scans
What is the gold standard management option of acute heart failure?
IV Loop Diuretics
Name two loop diuretics used to manage acute heart failure
Furosemide
Bumetanide
What is the management option of acute heart failure, with respiratory failure?
Continous positive airway pressure (CPAP)
When should beta-blockers stopped during acute heart failure?
They should only be stopped when the patient has a heart rate < 50bpm, second/third degree atrioventriculae block or shock
What heart failure classification is associated with hypertrophic obstructive cardiomyopathy?
Diastolic Heart Failure (HF-pEF)
What are the three clinical feature of right sided heart failure (cor pulmonale)?
Increased JVP
Ankle Oedema
Hepatomegaly
What is the first line investigation used to diagnose chronic heart failure?
N-Terminal Pro-B-Type Natriuretic Peptide (NT‑proBNP) Blood Test
What BNP level is deemed as high?
> 400
What NTproBNP level is deemed as high?
> 2000
What is the next step when BNP/NTproBNP levels are high?
2 week ECHO scan referral
What BNP level is deemed as raised?
100 - 400
What NTproBNP level is deemed as raised?
400 - 2000
What is the next step when BNP/NTproBNP levels are raised?
6 week ECHO scan referral
What is the NYHA class I of chronic heart failure?
No clinical features
No limitation of physical activity
What is the NYHA class II of chronic heart failure?
Mild clinical features
Slight limitation of physical activity, comfortable at rest however activity results in faitgue, palpitations or dyspnoea
What is the NYHA class III of chronic heart failure?
Moderate clinical features
Marked limitation of physical activity, comfortable at rest however less then ordinary activity
What is the NYHA class IV of chronic heart failure?
Severe clinical features
Severe physical limitation, clinical features at rest
What is the first line pharmacological management option of chronic heart failure?
ACE Inhibitor
AND
Beta Blocker
What two beta-blockers improve long term prognosis of chronic heart failure?
Bisoprolol
Carvediol
What two beta-blockers improve long term prognosis of chronic heart failure?
Bisoprolol
Carvediol
What are the two second line pharmacological management option of chronic heart failure?
Aldosterone/Mineralocorticoid Antagonists
Angiotension Receptor Blockers
What montioring should be conducted when individuals are administered ACE inhibitors and aldosterone antagonists? Why?
Potassium Levels
Hyperkalaemia Risk
What are the four third line pharmacological management options of chronic heart failure?
Ivabridine
Sacubitril-Valsartan
Digoxin
Hydralazine & Nitrates
When is ivabradine used to manage acute heart failure?
Heart Rate > 75bpm
AND
Left Ventricular Fraction < 35%
When is sacubitril-valsartan used to manage acute heart failure?
Left Ventricular Fraction < 35%
What should be conducted before starting heart failure patients on sacubitril-valsartan?
ACEI/ARB Washout Period
This involves stopping these medications 36 hours before administration
When is digoxin used to manage acute heart failure?
Coexistent atrial fibrillation
When is hydralazine, with nitrates, used to manage acute heart failure?
Afro-Caribbean Patients
Which drug class does not improve mortality in heart failure?
Diuretics
What is the first line management option of acute angina attacks?
Sublingual Glyceryl Trinitrate
What are the two first line prophylactic management options of stable angina?
Beta-Blocker
OR
Calcium Channel Blockers
What is the first line prophylactic management option of angina - in those with heart failure?
Beta-Blockers
What is the first line prophylactic management option of angina - in those with asthma?
Calcium Channel Blockers
Which two calcium channel blockers should be administered as monotherapy when prophylactically managing angina?
Verapamil
Dilitiazem
Which two calcium channel blockers should be administered when administered in compinated with a beta-blocker, when prophylactically managing angina?
Amlodpine
Nifedipine
These are known as longer-acting dihydropyridine calcium channel blockers
Which calcium channel blocker should not be prescribed with beta-blockers? Why?
Verapamil
Complete heart block risk
What are the two acute management options of angina?
Aspirin
What are the four second line prophylactic management options of angina - when individuals cannot toelrate dual therapy with a calcium channel blocker and beta blocker?
Long Acting Nitrate
Ivabradine
Nicorandil
Ranolazine
Name a long actine nitrate used to manage angina
Isosorbide Mononitrate
When is a complication of long acting nitrates? How do we prevent this complication?
Nitrate Tolerance
Asymmetric dosing interval, daily nitrate free time of 10 - 14 hours
What is the most important risk factor of aortic dissection?
Hypertension
What are the five clinical features of aortic dissection?
Sharp, Tearing Chest/Back Pain
Weak Peripheral Pulses
Asymmetrical Blood Pressure
Hypertension
Aortic Regurgitation
What is type A aortic dissection?
It involves the ascending aorta
What is type B aortic dissection?
It involves the descending aorta
What is type B aortic dissection?
It involves the descending aorta
What are the five clinical features of aortic dissection?
Sharp, Tearing Chest/Back Pain
Weak Peripheral Pulses
Asymmetrical Blood Pressure
Hypertension
Aortic Regurgitation