Cardiovascular system and disease Flashcards

1
Q

What are the two functions of the heart?

A
  1. To pump oxygenated blood to the body tissues
  2. To pump deoxygenated blood to the lungs to be oxygenated
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2
Q

Label the missing blood vessels

A
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3
Q

Label the missing parts of the heart

A
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4
Q

Describe the two interconnecting networks of muscle fibres in the heart

A
  • Called syncitia
  • All the muscle around the atria is interconnected and all the muscle around the ventricles is interconnected
  • Each syncitium contracts as a unit because once one muscle cell is stimulated the while syncitium contracts
  • The syncitia are eletrically insulated from each other by fibrous connective tissue
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5
Q

Describe cardiac muscle compared to skeletal muscle

A
  • Fibres are shorter in length in cardiac muscle
  • Fibres are branched in cardiac muscle
  • Cardiac muscle fibres are anchored to each other by intercalted discs and have gap jounctions between them to allow action potentials to pass between fibres
  • The fibres are autorhythmic
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6
Q

How is cardiac muscle autorhythmic and why is this useful?

A
  • The fibres are self excitable and can spontaneously depolarise and contract
  • This feature is useful as it allows the heart to beat continuously even when you’re sleeping
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7
Q

What is the difference in action potential time for cardiac muscle compared to skeletal muscle and what does this result in?

A
  • Action potenial is longer in cardiac muscle (0.25 sec for cardiac muscle)
  • This results in a plateau as there is a delay before repolarisation
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8
Q

Describe why there is a plateau in the contraction cycle for cardiac muscle (the break between action potential and repolarisation)

A
  • Calcium ions enter the axon as sodium ioons are being pumped out and this prevents repolarisation
  • This is because calcium ions stop the normal movement of potassium ions
  • The membrane potential balances out at 0mV
  • There is then a delay between the action potwential and repolarisation
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9
Q

How is each contraction of the heart co-ordinated?

A
  • By the pacemaker
    • Sinoatrial node
  • By having conduction pathways
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10
Q

How does the SA node help to co-ordinate the contrction of the heart?

A
  • It is a bundle of specialised cadiac muscle ceels with have self excitability and autorhythmic depolarisation and set the heart rate based on the nervous system
  • It has a rate of 100 action potentials per minute and this is naturally slowed at rest by the vagus nerve to 75 per minute which is the typical resting heart rate
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11
Q

Describe the conduction pathway up to the bundles of his dividing

A
  • Action potential from the SA node causes contraction of the atria
  • The action potential reaches the atrioventricular node and enters the bundle of his
  • The AV node delays the impulse to allow ventricular filling to occur before contraction of the ventricles
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12
Q

Describe the conduction bathway from the AV node delaying the impulse

A
  • The bundles of his divide into left and right branches of perkinje fibres where speed of conduction is 6 times faster than through ventricle muscle
  • This impulse causes the ventricles to contract from the apex up towards the valves
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13
Q

Label the points on the normal ECG

A
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14
Q

If the SA node failed to function what would happen?

A
  • The AV node would take over as the pace maker of the heart
  • The heart rate would be slower
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15
Q

What prevents the valves of the heart opeing back up when pressure is applied?

A

Cordae tendineae

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16
Q

Why is it a probelm if the heart beats too fast?

A

Flood flow will decrease as the ventricles don’t have enough time to fill properly

17
Q

What is first degree AV block?

A

prlonged gap between p wave and QRS complex but for every atrial depolarisation there is ventricular depolarisaion

18
Q

What is second degree AV block?

A

Not all p waves cause QRS complexes normally seen in a ration e.g. 2:1 means every second p wave causes a QRS complex

19
Q

What is third degree AV block?

A

No association between p waves and QRS complexes

20
Q

What are the 5 things thsat can lead to heart failure?

A
  1. Disorder of coronary arteries
  2. High blood pressure (hypertension)
  3. Cardiomyopathy (disease of the heart muscle)
  4. Heart valve disorder
  5. abnornal heart rhythm
21
Q

What are the risk factors for Heart disease?

A
  • High blood cholesterol
  • High blood pressure
  • If the person is a smoker
  • If the person is obese
  • lack of regular exercise
  • If the person has diabetes mellitus
  • There is also a gentetic link to males
22
Q

What is hypertension?

A
  • High blodd pressure
  • Defined as systolic BP above 140mmHg
  • Diastolic BP avove 90mmHg
23
Q

What is athersclerosis?

A
  • Most common vascular disease
  • Underlying disease process in most corornary artery disease
  • Larger arteries are affected
    • Abdominal Aorta
    • Comonon iliacs
    • Coronary Arteries
24
Q

What is coronary artery disease?

A
  • Narrowed arteries with reduced blood flow to myocardium
  • Leads to damage of myocardium
  • Leads to coronary heart disease
  • Leads to Ischaemic heart disease

Symptoms range from angina to major myocardial infarction

Symptoms appear when coronary artery is 70-75% occluded

25
Q

What is angina?

A
  • Result of transient ischaemia
  • Pain experienced on exertion or stress causing increased HR and BP
  • Relived by rest or GTN spray
  • GTN spray is nitroglycerine
26
Q

What happens in an acute myocardial infarction?

A
  • There is arterial abstruction
  • This leads to acute myocardial ischaemia and death of cardiac muscle
  • Muscle is replaced by scar tissue which makes the pumping action of the heart weaker
  • The effects depend on site of infarction
  • conduction my be interrupted
  • can result in arrythmias
  • can result in sudden death
27
Q

How can an acute myocardial infarction be diagnosed?

A
  • By the presence of cardiac enzymes in the blood
    • Troponin
    • Creatinine kinase
  • ECG
    • Elevation in ST segment
    • Inversion of T wave
    • Enlarged Q wave
28
Q

What are the consequences of acute MI?

A
  • Arrythmias (e.g. VF)
  • Cardiogenic shock
  • Thrombus formation
    • Risk of emboli
  • Rupture of artery
  • Fibrous scar tissue has no contractility so may bulge on ventricular contraction