cardiovascular responses to shock (CVS 12) Flashcards
different types of shock
- hypovolaemic (haemorrhagic, non-haemorrhagic)
- cardiogenic (eg. acute myocardial infarction)
- obstructive (eg.cardiac temponade, tension pneumothorax, pulmonary embolism, severe aortic stenosis)
- distributive (neurogenic eg.spinal cord injury, vasoactive eg.septic shock, anaphylactic shock)
what is shock
an abnormality of the cirulatory system resulting in inadequate tissue perfusion and oxygenation
what is the effect of inadequate tissue perfusion and oxygenation during shock
inadequate tissue perfusion -> inadequate tissue oxygenation -> anaerobic metabolism -> accumulation of waste products -> cellular failure
MAP
- mean arterial pressure
- MAP = cardiac output (CO) x total peripheral resistance (TPR)
CO
- cadiac output
- the volume of blood pumped by each ventricle of the heart per minute
- CO = stroke volume (SV) x heart rate (HR)
stroke volume (SV)
= volume of blood pumped by each ventricle of the heart per heart beat
adequate tissue perfusion
- adequate tissue perfusion depends on adequate blood pressure and adequate cardiac output
- > MAP= CO x TPR
- > CO = HR x SV
- > factors that affect stroke volume: preload (affected by venous return), myocardial contractility, afterload
hypovolaemic shock
- > haemorrhagic
- > non-haemorrhagic
- loss of blood volume -> decreased bood volume -> decreased venous return -> decreased end diastolic volume -> decreased stroke volume -> decreased cardiac output and blood pressure -> inadequate tissue perfusion
effect of end diastolic volume (EDV) on stroke volume (SV) - frank starling curve
- as end diastolic volume (ml) increases, as does stroke volume (ml)
- stroke volume = tension
- EDV = fibre length = preload
cardiogenic shock
- > eg. acute myocardial infarction
- decreased cardiac contractility -> decreased stroke volume -> decreased cardiac output and blood pressure -> inadequate tissue perfusion
obstructive shock
- can be due to cardiac temponade, tension pneumothorax, pulmonary embolism, severe aortic stenosis
- > in this case = tension pneumothorax
- increased intrathoracic pressure -> decreased venous return -> decreased end diastolic volume ->decreased stroke volume ->decreased cardiac output and decreased blood pressure -> inadequate tissue perfusion
neurogenic shock (type of distributive shock)
- type of distributive shock
- can be due to injury to spinal cord
- loss of sympathetic tone -> massive venous and arterial vasodilation -> decreased venous return and decreased TPR -> decreased stroke volume (as a result of decreased venous return as it decreases end diastolic volume) -> decreased cadiac output and decreased TPR -> decreased blood pressure -> inadequate tissue perfusion
vasoactive shock (type of distributive shock)
- type of distributive shock
- eg. septic shock
- release of vasoactive mediators -> massive venous and arterial vasodilation, and also increased capillary permeability -> decreased venous return and decreased TPR -> decreased cardiac output and decreased blood pressure -> inadequate tissue perfusion
vasoactive
affecting the diameter of blood vessels (and hence blood pressure)
outlines of treatment of shock
- ABCDE approach
- high flow oxygen
- volume replacement
- inotropes for cardiogenic shock
- immediate chest drain for tension pneumothorax
- adrenaline for anaphylactic shock
- vasopressors for septic shock