Cardiovascular Pharm II Flashcards
What is heart failure associated with?
Decreased contractility
What does the decreased contractility in heart failure ultimately do
Tissues cant get enough O2 bc blood not pumping enough, this causing a sympathetic compensation
What things does the sympathetic system do to compensate for heart failure?
Increase arteriolar constriction (afterload)
Increase blood volume (preload)
Increase heart rate
Sympathetic compensation of heart failure: arteriolar constriction
Increases TPR-vascular resistance-increased afterload
- now heart has to constrict even harder against arterioles
- TX: want to decrease afterload so heart wont have to work as hard
Sympathetic compensation of heart failure: increased blood volume
- increased blood pressure
- this is a problem because the heart is already failing and now has to pump extra fluid around
- problem at the level of the veins
- preload increased (increased, end diastolic and increased venous return, all mean the same things)
- TX: want to decrease preload with diuretics or venodilate
Sympathetic compensation for Heart failure: increased HR
- leads to arrhythmia
- control this by decreasing HR
- do this with B1 blocker in low dose, because B1 blockers reduce HR AND contractility, and you do not want to decrease contractility in an already failing heart
Why do we use low does beta blocker in heart failure
Because it will Lower the heart rate without affecting contractility. If you give a higher does of B blocker, it could lower contractility, and we dont want that in an already failing heart
How does the heart compensate during failure?
- increased SANS activity
- myocardial hypertrophy
- increased RAAS
What do all of the compensatory actions of the heart during heart failure lead to
Cardiac remodeling
-fibrosis
What is the main target when trying to combat cardiac remodeling in cardiac failure
Aldosterone
-epi and NE are potential targets too, but aldosterone main one
If you something decreases remodeling, what else does it do
Increases survival
If something increases survival, what else does it do
Decreases remodeling
What is the main goal when treating someone with heart failure
Improve survival
Why is there an increase in heart failure today
Because more people are surviving heart attacks and are left with failing hearts instead of dying right away
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A Note Card- by Champ
What are the drugs used to treat CHF
- RAAS inhibitors
- B blockers
- Diuretics
- Inotripic drugs
- Other vasodilators
- If channel blocker
1-3 are the first line drugs, the others are back up
What are the type 3 drugs we use to treat CHF
- RAAS inhibitor (ACEI or ARB, ACEI first)
- B blocker (metoprolol)
- Diuretics (loops and thiazides)
What is the very first drug usually given in CHF
ACEI
What is the second drug usuallygiven for CHF
Metoprolol
Why do we not give inotropic drug first for CHF?
Digoxin is very dangerous, and it’s the best option of them all. Don’t want to risk this with patients
What do diuretics do in CHF
Decrease fluid
What do ionotropic drugs do for CHF
Increase contractility
What is the only inotropic drug that is ok for chronic use
Digoxin
What are the two inotropic drugs that are for acute only when treating CHF?
B agonists Phosphodiesterase inhibitors (inamrinone)
What are some other vasodilator that can be used for CHF treatment but are not first choice
- Neprilysin inhibitor (sacubitril)
- amlodipine (CCB)
What is considered first line therapy for CHF?
ACEI (and ARB but mostly ACEI)
Mechanism of ACEI in treating CHF
- inhibit the vasoconstriction effects of ANGII
- inhibit the retention of sodium and water by inhibiting aldosterone
- prevent aldosterone-mediated cardiac remodeling
Cardiovascular actions of ACEI in CHF
Preload is reduced
Afterload is reduced
Reduce the long term remodeling and therefore INCREASES SURVIVAL