Cardiovascular Disorders Flashcards
Types of Brugada Syndrome
*Picture from Q1 Exam 3 (154481)
What classic ECG finding is identified in arrhythmogenic right ventricular cardiomyopathy?
Epsilon wave - positive ecg deflection after QRS segment in leads V1-V3
Most common bowel site of secondary aortoenteric fistula?
Duodenum
Monitoring the progression of AAA (by size)
< 5.5 cm - US annually
>/= 4.5cm with greater expansion rate - US every 6 months
Can also use CT or MRI
> 5.5 cm - Surgery
Risk factors for superficial thrombophlebitis
- Intrinsic hypercoagulable states
- Varicose veins
- IV catheter use
- Pregnancy
- Hx of vein excision or ablation
Differences in diagnosis and management between uncomplicated and complicated superficial thrombophlebitis
Uncomplicated:
- Venous segment <5cm
- Remote from saphenofemoral or saphenopopliteal junctions
- Lack of medical risk factors for hypercoagulability
TX: NSAIDs, extremity elevation, compression
Complicated:
- Venous thrombosis >5cm
- Within 5cm of a deep vein
- Recurrent or migratory thrombophlebitis
- Suppurative thrombophlebitis
TX: Anticoagulation, often require antibiotic administration or vein ligation
What test is gold standard to confirm myocarditis?
Endomyocardial biopsy
Most common cause of myocarditis worldwide/US
T. cruzi (Chagas disease)/viruses such as parvovirus B19
Which is the best sonographic view to assess for cardiac wall motion abnormalities?
Parasternal short-axis view
Most common presenting symptom in patients with acute aortic dissection?
Chest pain
First step in evaluation of an LVAD patient
Auscultate precordium to detect a hum or “whirr” to determine if pump is functioning - absence points to mechanical failure including an interrupted power source or controller malfunction
How to check BP of an LVAD patient
With a doppler or arterial line - may not have a pulse if there is no longer innate cardiac contractility
Definitive tx for constrictive pericarditis
Paricardiectomy
Symptoms of constrictive pericarditis
Similar to heart failure (especially right-sided HF)
- Fluid overload (dependent edema, anasarca)
- Diminished cardiac output (fatigue, dyspnea on exertion)
- Kussmaul sign (increase in JVP during inspiration)
- “Dip and plateau” LV filling (diastolic) tracing
- Pericardial knock
Causes of constrictive pericarditis
- Idiopathic
- Infectious (viral, TB, fungal, parasitic)
- Postcardiac surgery
- Postradiation therapy
- Connective tissue disorder
- Misc (uremic, malignant, drug-induced, sarcoid)
Constrictive Pericarditis vs. Restrictive Cardiomyopathy
CP: results from scarring and consequent loss of elasticity of the pericardial sac
RC: disease of the myocardium that results in restricted ventricular filling
Causes of restrictive cardiomyopathy
- Amyloidosis
- Sarcoidosis
- Hemochromatosis
- Tropical endomyocardial fibrosis
What nerve overlies the pericardium and must be carefully avoided at surgery?
Phrenic nerve
What dissection presentation predicts a poorer outcome?
In or near the carotid artery resulting in stroke-like symptoms
What is the most frequent site of arterial embolism?
Bifurcation of common femoral artery
What is the most common presentation in patients who are diagnosed with an abdominal aortic aneurysm?
Asymptomatic
How to monitor AAA by size
4-4.9cm - US annually
5-5.4cm - US every 6 months
>5.5cm or aneurysms with rapid expansion rate - elective surgery
Screening criteria for AAA
One-time screening for AAA by ultrasonography in men aged 65-75 who have ever smoked
Low flow (ischemic) vs. high flow (nonischemic) priapism
- Low flow painful
- Pathophys of low flow = decreased venous outflow; high flow = increased arterial inflow
- Shaft rigid and painful in low flow; shaft partially rigid and painless in high flow
- Glans soft in low flow; hard in high flow
Causes of low flow priapism
- Sickle cell
- Erectile dysfunction drugs
- Other medications and drugs
- Idiopathic
Causes of high flow priapism
- Arterial-cavernosal shunt formation (groin or straddle injury)
- High spinal cord injury or lesion
Way to distinguish between low flow and high flow priapism
Cavernosal blood gas - normal in high flow and with pH <7.25, CO2>60 and O2<40 in low flow
Which type of priapism is urologic emergency?
Low flow - requires draining corpora cavernosa blood or injecting phenylephrine into corpora cavernosa
ECG findings indicative of posterior wall MI
- ST segment depressions in leads V1, V2, and V3
- Tall, broad R waves in V2-V3
- Dominant R wave in V2 (R/S ratio > 1)
On posterior leads -> elevations in leads V7 and V8
Sgarbossa Criteria
- Concordant ST elevation > 1mm in leads with a positive QRS (5pts)
- Concordant ST depression > 1mm in V1-V3 (3pts)
- Discordant ST elevation 5mm in leads with a negative QRS (2pts)
3pts = STEMI
What medications require increased dose of adenosine?
- Methylxanthines
- Caffeine
- Theophylline
What medications require a lower dose of adenosine?
- Carbamazepine
- Dipyridamole
- Cardiac transplant
What are mycotic aneurysms?
Focal arterial dilatations
Etiology of mycotic aneurysms?
- Direct bacterial inoculation
- Bacteremic seeding
- Contiguous infection
- Septic emboli
Typical presentation of mycotic aneurysm
- Painful, pulsatile, enlarging mass associated with systemic symptoms of infection (fever, malaise, myalgias)
- At deeper sites, a palpable mass may not be appreciated
- When in femoral arteries, frequently associated with acute limb ischemia due to thrombosis within the aneurysm
Typical microbiology of mycotic aneurysm
- Staph aureus
- Staph epidermidis
- Salmonella
- Strep pneumo
Occasionally syphilis or Mycobacterium
Dx of mycotic aneurysm
CTA or MRA
Tx of mycotic aneurysm
Abx and aggressive surgical debridement
Diagnostic criteria for pulmonary hypertension
Mean pulmonary arterial pressure greater than 25 at rest or greater than 30 during exertion
Also with decreased cross-sectional area of the pulmonary vascular bed, increased pulmonary blood flow, increased pulmonary venous pressure
Physical exam findings of pHTN
Initially cyanosis
S1 followed by ejection click
S2 narrowly split
Increased intensity of pulmonary component of S2
As progresses, JVD, hepatomegaly, peripheral edema from RHF
What is first line tx for torsades?
Mg sulfate
Most common causes of prolonged QT
- Drug interactions (procainamide, quinidine, propafenone, flecanide, TCAs, droperidol, phenothiazines, erythromycin, fluoroquinolones, methadone)
- Myocardial ischemia
- Electrolyte disturbances (hypomagnesemia, hypokalemia)
Other than Mg sulfate and defibrillation, what is another tx for torsades?
Increase HR to shorten ventricular repolarization, also known as overdrive pacing
Avoid amiodarone as this can cause QT prolongation itself
What is the most common dysrhythmia following commotio cordis?
Ventricular fibrillation
Risk window on ECG for commotio cordis
Upstroke of T wave
Medications to avoid in aortic stenosis
Nitroglycerin, diuretics, or anything that reduces preload
Murmurs
Remember to study them and how they increase/decrease with maneuvers
What is the initial tx for symptomatic congenital long QT syndrome?
beta-blockers - most effective being propranolol and nadolol
What conditions can multifocal atrial tachycardia be present?
Common in elderly patients with chronic lung disease
Also seen in heart failure and sepsis
Time troponin is detectable from onset of ischemia
3-12 hours
Peak of troponin after ischemia
24-48 hours
Time for troponin to return to baseline
5-14 days
Time CK is detectable from onset of ischemia
3-12 hours
Peak of CK after ischemia
24 hours
Time for CK to return to baseline after ischemia
48-72 hours
What is the role of beta-adrenergic blocking agents in acute MI?
Given within 24 hours of presentation reduce risk of developing ventricular dysrhythmias
What cardiac biomarker has highest sensitivity and specificity?
Troponin
When is the cardiac biomarker CK useful?
Useful for diagnosis of reinfarction
Absolute contraindications to anticoagulation
- NSGY within past 10 days
- Active bleeding
- Severe bleeding diathesis
- Platelet count <20,000
- Severe allergy
Relative contraindications to anticoagulation
- Mild-moderate bleeding diathesis
- Platelet count >20,000 but less than normal
- Brain mets
- Recent major trauma
- Major abdominal surgery in last 2 days
- GI or GU bleeding in past 14 days
- Endocarditis
- Severe hypertension
When anticoagulating a patient with DVT with enoxaparin and warfarin, when is it safe to have the patient stop enoxaparin
When INR is greater than 2.0 for 2 consecutive days
Etiology of acute MR
ISCHEMIC:
- Acute MI with papillary muscle displacement
- Trauma
NONISCHEMIC:
- Ruptured mitral chordae tendineae (flail leaflet) due to myxomatous disease (MVP)
- Infective endocarditis
- Blunt chest trauma
- Rhematic heart disease
- Spontaneous
Clinical presentation of acute MR
- Sudden onset and rapid progression of pulmonary edema, hypotension, and s/s of cardiogenic shock
- Systolic murmur is often soft, harsh, low-pitched, and decrescendo, often ending well before A2; best heard along left sternal border and base of heart
Types of Wellens Syndrome
Really a continuum, but need to recognize both In leads V1-V2... Type A: Biphasic T wave Type B: Deeply inverted T wave Q143890
What is the most common symptom of cardiac ischemia in patients older than 85 years?
Dyspnea
What initial anti-hypertensive should be initiated in African American population (including those with diabetes)?
Thiazide or CCB
What is the most likely cardiac arrest rhythm in someone who arrests in public (as opposed to at home)?
Vfib
What diagnostic test has the highest sensitivity for diagnosing a DVT?
Venography (Duplex US still first-line imaging)
What antibiotic is recommended as prophylaxis for high-risk patients undergoing a dental extraction?
Amoxicillin (2g by mouth)
What affect will atropine have on third degree heart block?
It alters conduction ratios without changing the appearance of the ventricular escape rhythm
What entities may cause a falsely large E-point septal separation?
Mitral stenosis and aortic stenosis
Mechanism of action of atropine
Competitively inhibits acetylcholine at the AV node from the vagus nerve
What medication should be avoided in myocarditis
NSAIDs (can exacerbate disease and increase mortality)
What medication is contraindicated in the tx of a child younger than 12 months old with SVT? In what other situations is this medication contraindicated?
CCB due to poor calcium reserves in the sarcoplasmic reticulum in infants
(Also contraindicated in children with heart failure, suspected WPW, or wide QRS complex)
What is the most common significant dysrhythmia in pediatrics?
SVT
What is the most common cause of tricuspid valve stenosis?
Rheumatic heart disease
Murmur with VSD
Harsh, holosystolic murmur heard best at left lower sternal border
Murmur may no longer be present later due to reversal of shunting and a loud S2 caused by pulmonary hypertension
What is an epsilon wave?
Small positive deflection at end of QRS complex that is most specific finding for arrhythmogenic right ventricular dysplasia