Cardiovascular Considerstions

Question 1

In individuals with high CVD

Answer 1

Avoid lopinavir/ritonavir based regimens
If a boosted PI is the desired option use an Atazanavir based regimen over a Darunavir based one
Avoid abacavir

Question 2

CKD

Answer 2

If eGFR < 60 use Darunavir with c/r
If eGFR 30-60 use TAF
Avoid using TDF, lopinavir/ ritonavir or Atazanavir in those with worsening renal function with moderate to severe proteinuria

Question 3

Dose adjustment of ART in renal impairment

Answer 3

Lamivudine and emtricitabine doses are adjusted in those with eGFR <30mL/min