ARV Mechanisms Of Action

Question 1

Mechanism of action of fostemsavir

Answer 1

Binds gp120 and prevents conformational change required for attachment of HIV to the host cell

Question 2

Mechanism of action of ibalizumab

Answer 2

It’s an IgG4 MAb which binds to domain 2 of CD4 T cell receptors. Leads to confirmational changes in the CD4 T cell receptor go 120 complex and prevents HIV fusion and entry

Question 3

Mechanism of action of Lenacapavir

Answer 3

Multiple mechanisms affecting virus life cycle including nuclear transport virus assembly and release and capsid assembly