Cardiopulmonary 1: HTN Flashcards
benefit of olmesartan
can titrate very precisely - may be beneficial for petite patient
endocrine adverse effect of spirinolactone
gynecomastia
3 main AEs ACE inhibitors
angioedema
cough
teratogenicity
ACC/AHA Guidelines: Normal BP
<120 / <80
ACC/AHA Guidelines: Elevated BP
120 - 129 / <80
ACC/AHA Guidelines: HTN stage 1
130 - 139 systolic OR 80 - 89 diastolic
ACC/AHA Guidelines: HTN Stage 2
Systolic at least 140 OR diastolic at least 90
ACC/AHA Guidelines: threshold to start treatment for a patient with clinical cardiovascular disease or a 10 year atherosclerotic cardiovascular disease (risk greater than 10%)
start treatment for a pressure greater than or equal to 130/80
ACC/AHA Guidelines: threshold to start treatment for a patient with no clinical CVD and no 10 year atherosclerotic CVD (risk less than 10%)
start treatment at greater than or equal to 140/90
ACC/AHA Guidelines: when should you consider two anti htn agents?
if patient, regardless of their risk, was greater than 20/10 mmHg over goa.
ACC/AHA Guidelines: BP goal for ALL patients
< 130/80
blood pressure goal when someone is hospitalized
generally will be a little more liberal. won’t intervene until over 150 systolic. do not want to risk organ perfusion.
ACE inhibitor (definition)
angiotensin converting enzyme inhibitor
ARB (definition)
angiotensin II receptor blocker
DHP CCB (definition)
Dihydropyridine calcium channel blocker
DHP CCBs are more geared towards
pressure control rather than rhythm control
drug of choice categories for HTN in non-african american patients with no compelling indication (3)
thiazides
ACE-1/ARB
DHP CCB
drug of choice categories for African-American patients with no compelling indication (2)
Thiazides
DHP CCB
ACE inhibitors and ARBs in African American patients
inferior if given as mono-therapy for HTN
drugs of choice categories for non African-American diabetic patients without CKD (3)
Thiazides
ACE-1/ARB
DHP CCB
Drug of choice categories for African-American patients with diabetes but no CKD (2)
Thiazides
DHP CCB
Drug of choice category for patient of any race who has CKD
ACE-1
When a patient with HTN or diabetes starts approaching CKD, what will they be prescribed and why?
an ACE because they are renal protective and may slow down progression of CKD.
Drug of choice for patient of any age and race who is s/p MI ?
What if HF is present ?
- Beta blocker + ACE-1
- Aldosterone antagonist if HF is present
What drug should be prescribed for a patient of any age/race who is s/p MI and also has a degree of HF present?
Aldosterone antagonist
Drug of choice for patient of any age/race who is being medicated for recurrent stroke prevention
Thiazide + ACE-1
Drugs of choice for patient with heart failure of any age/race (4)
Beta Blocker + ACE-1
Diuretics for fluid retention
Aldosterone antagonist
Hydralazine / ISO DN
Why thiazides + ACE-1 for patients at risk for recurrent stroke?
In setting of stroke, you may not want to have beta blocker because you don’t want to slow down heart and risk perfusion.
What kind of diuretic is preferred in heart failure?
loop
Beta Blockers after MI
May benefit the heart by supporting it/giving it a slight break
african american patients and hydralazine/ISO DN
in the setting of HF, pts do better or at least do not do worse than patients just on ace inhibitors.
Four major classes of anti hypertensives (first lines)
Thiazides
CCBs
ACE-Is`
ARBs
If response is not effective enough on first line therapy, what should you do next?
increase dose (up to max dose) of that first line drug and reevaluate prior to adding a second agent.
disadvantage of adding second agent
unsure of where potential side effect may be coming from
what to consider before putting patient on a single tablet combination drug? (ie: an ACE/thiazide) Why?
try the patient on the two separate tablets first before putting them on a combo tablet. evaluate their response. it is easier to titrate individual agents separately. combo drug doses are fixed. once patient is solid for a month or two, then consider combo pill.
Advantages of combo drugs
less pill burden
disadvantage of combo drug
cannot titrate
once established that max dose of first line is not effective enough for pt’s HTN, what is the appropriate next step?
start the pt on a second agent as an individual pill. do not start the pt on second agent as a combo pill.
later line alternatives “A” list (5)
and why are they later line?
- alpha 1/beta blockers
- direct vasodilators
- central alpha2-adrenergic agonists
- beta-blockers
- loop diuretics
- too powerful as a first line treatment
example: direct vasodilator
A list
hydralazine
example: beta-blocker
A list
metoprolol
example: loop diuretic
A list
furosemide
which beta blocker is recommended to pregnant women with htn?
labetalol
other use for labetalol, carvedilol, or hydralazine
hypertensive urgency
you’ll more often see furosemide prescribed for
heart failure rather than htn
later-line alternatives “B” list (3) for htn
- aldosterone antagonists
- alpha-1 blocker
- vasodilating beta-blocker
example: aldosterone antagonist
B list
spirinolactone
Example: vasodilating beta blocker
B list
nebivolol
nebivolol FYI
not a popular medication
Mechanism of action: thiazide
inhibit active exchange of Na and Cl (in equal amounts) in the distal convoluted tubule (last step of tubule)
*most often used
mechanism of action: loop diuretics
inhibit exchange of Na/Cl/K on thick segment of ascending loop of henle (where a lot of concentration takes place)
*HF
mechanism of action: K sparing diuretics and main function
inhibits reabsorption of Na in distal convoluted tubule and collecting duct. The main function is antagonizing aldosterone (while sparing potassium). Allows you to pee out sodium and hold on to K.
you may often see K sparing diuretics prescribed with _____ and why?
thiazides, which waste a lot of K. adding a K sparing diuretic may help prevent hypokalemia.
aldosterone is released when body perceives
that you need fluid
what does it mean when it is said that K sparing diuretics antagonize aldosterone?
that they bind to receptor and prevent aldosterone from being released and retaining fluid. They allow your body to excrete the fluid instead.
Therapeutic indications of thiazides (2)
hypertension
edema
3 thiazide drugs used for HTN
chlorothiazide
hydrochlorothiazide
chlorthalidone
which thiazide do you see in pediatric htn
chlorothiazide
which thiazide do you see more in adult htn?
hydrochlorothiazide
chlorthalidone vs hctz
old thiazide drug used for htn which has a longer duration of action
thiazide drug used for edema
metalozone
metolazone may be seen when a patient is already prescribed
a loop diuretic. it provides an extra push.
drug interactions involving thiazide involve
electrolytes
thiazide and digoxin
k wasting drug predisposes pt to hypokalemia, putting them at risk for digoxin toxicity. requires tighter monitoring.
thiazide and lithium
thiazide wastes sodium. lithium resembles sodium to the kidney. if you are wasting a lot of sodium, the lithium will be retained by the kidney and can accumulate, resulting in lithium toxicity.
requires tighter monitoring.
thiazide and electrolyte supplements
the electrolyte supplement may not be as effective
thiazide and ototoxicity
no risk, unlike other diuretics
thiazide and sulfonamide allergy
there is a sulfa-like compound in thiazide, proceed with caution. understand what the allergy actually is before proceeding.
thiazide use in anuric renal failure
if you have an impaired GFR (<10ml/min) or CrCl (<30), thiazide will not be effective.
normal creatinine clearance is usually
> 100ml/min
Adverse effects of thiazides:
what will it decrease? (5)
Mainly sodium, potassium, chloride
also phosphorus and magnesium
adverse effects of thiazides:
what will it increase?
calcium, uric acid
potentially glucose and lipids
adverse effect of thiazide, unrelated to electrolytes
photosensitivity and propensity to burn
Most powerful diuretics are
loop diuretics
aside from HF, what are two other indication for loop diuretics re: edema?
hepatic cirrhosis and renal disease (CrCl <30ml/min)
if a patient has a CrCl < 30 mL/min, which diuretic would be appropriate?
Loop diuretic
4 Examples of loop diuretics
Lasix
Bumetanide
Ethacrynic acid
Torsemide
Most potent loop diuretic
bumetanide (bumex)
How many doses per day may you need of lasix?
2-3
If patient has a true sulfa allergy, which loop diuretic is safest? and what are two downsides of this drug?
ethacrynic acid
- PO is extremely expensive
- ototoxic