Antimicrobials: Monobactams

Question 1

monobactam category drug

Answer 1

aztreonam

Question 2

monobactams are only used for

Answer 2

gram negative species

Question 3

monobactam activity

Answer 3

moderate to excellent against gram neg aerobes including pseudomonas

Question 4

the monobactam, Aztreonam, is a good substitute for

Answer 4

the ahminoglycosides in patients at risk for toxicity

Question 5

cross allergy with PCNs/cephs and monobactams (aztreonam)

Answer 5

unlikely, except if the allergy is to ceftazidime.

Question 6

why is ceftazidime allergy dangerous in aztreonam use?

Answer 6

because the side chains are the same

Question 7

Aside from a substitute for aminoglycosides, what is another circumstance where monobactams like aztreonam are useful?

Answer 7

if you are using many other drugs.

because this drug has a narrow activity, it is not often used on its own but it is used in combo with other abx.

Question 8

aztreonam will be used on its own in what disease state?

Answer 8

CF for pseudomonas or exacerbation (inhaled)

Question 9

aztreonam is often used with what other drugs?

Answer 9

clindamycin

macrolides