Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Stage 3 > Cardiology: Acute Coronary Syndrome + Stable Angina > Flashcards

Cardiology: Acute Coronary Syndrome + Stable Angina Flashcards

1
Q

What investigations do you do in someone presenting with symptoms of an ACS?

A

1) 12 lead ECG
2) Troponin
3) Bloods
4) Consider CXR
5) Consider CTPA/ D-dimer if suspicious of PE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the two most important investigations to do in someone presenting with symptoms of an ACS?

A

12 lead ECG + troponin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How do you diagnose a STEMI?

A

Raised troponin + persistent ST elevation OR new LBBB + cardiac chest pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the types of ACS?

A

1) STEMI
2) NSTEMI
3) Unstable angina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the diagnostic features of NSTEMI?

A

Raised troponin + normal/abnormal ECG but NO ST elevation + cardiac chest pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the diagnostic features of unstable angina?

A

Normal troponin + normal/abnormal ECG changes + cardiac chest pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is acute coronary syndrome?

A

A constellation of symptoms and clinical findings which results from impaired cardiac perfusion at rest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the difference between myocardial infarction and angina?

A

Myocardial infarction is caused by underperfusion of the myocardium leading to death of myocardial tissue - it is distinguished from angina by this death of tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the non-modifiable risk factors for ACS?

A

1) Age
2) Male sex
3) Family history
4) Ethnicity - particularly South Asians

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the modifiable risk factors for ACS?

A

1) Smoking
2) Hypertension
3) Hyperlipidaemia
4) Hypercholesterolaemia
5) Obesity
6) Diabetes
7) Stress
8) High fat diets
9) Physical inactivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What causes STEMI?

A

Complete occlusion of a coronary artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What causes NSTEMI?

A

Severe but incomplete stenosis/occlusion of a coronary artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are other causes of NSTEMIs?

A

Lack of cardiac oxygenation for other reasons:
1) Severe sepsis
2) Hypotension
3) Hypovolaemia
4) Coronary artery spasm
- These cases might not respond to or need conventional treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Why might a suspected NSTEMI not respond to conventional treatment?

A

The NSTEMI might be due to lack of cardiac oxygenation for other reasons:
1) Severe sepsis
2) Hypotension
3) Hypovolaemia
4) Coronary artery spasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How does ACS typically present?

A

Chest pain/tightness:
S - central/left sided
O - sudden
C - crushing/chest tightness
R - left arm, neck and jaw
A - nausea, sweating, clamminess, SOB ± vomiting/syncope
T - constant
E - worsened by exercise/exertion and may be improved by GTN
S - often extremely severe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are atypical presentations of ACS?

A

1) Epigastric pain
2) No pain
3) Acute breathlessness
4) Palpitations
5) Acute confusion
6) Diabetic hyperglycaemic crises
7) Syncope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which patients are more likely to have atypical presentations of ACS with no pain?

A

Elderly + diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are cardiac non-MI causes of chest pain?

A

1) Myocarditis
2) Pericarditis
3) Cardiomyopathy
4) Valvular disease
5) Cardiac trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are pulmonary non-MI causes of chest pain?

A

1) PE
2) Pneumonia
3) Pneumothorax

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is a vascular cause of chest pain?

A

Aortic dissection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are GI causes of chest pain?

A

1) Oesophageal spasm
2) Oesophagitis
3) Peptic ulcer
4) Pancreatitis
5) Cholecystitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are MSK causes of chest pain?

A

1) Rib fracture
2) Costochondritis
3) Muscle injury
4) Herpes zoster

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What do you you not need if you see persistent ST elevation or new LBBB on ECG?

A

Troponin - clear STEMI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How do you diagnose STEMI?

A

1) ST segment elevation > 2mm in adjacent chest leads
2) ST segment elevation > 1mm in adjacent limb leads
3) New LBBB with chest pain or suspicion of MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

How do you diagnose NSTEMI?

A

Two of:
1) Cardiac chest pain
2) Newly abnormal ECG which is NOT ST-elevation
3) Raised troponin (with no other reasonable explanation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Which is the single most important investigation in a patient who may have an MI and why?

A

ECG - defines immediate management and should not be delayed for any other investigation, if an ECG shows STEMI then troponin is essentially irrelevant and the patient requires immediate treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

When does troponin need to be performed?

A

At least 3 hours after pain starts (may also need to be repeated 6-12h after the start of pain if initial result is equivocal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Which bloods do you do in suspected MI?

A

1) Troponin
2) Renal function
3) Blood glucose
4) Lipid profile
5) FBC & CRP - to rule out infectious causes of chest pain
6) D-dimer - may be used in appropriate patients to rule out PE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Why would you do a CXR in MI?

A

1) Looking for pulmonary causes of chest pain
2) Looking for pulmonary oedema (as a complication of MI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What might you see on ECG in NSTEMI?

A

T wave abnormalities e.g. inversions in the same vascular territories as STEMIs - however changes can also often not include all the specific leads for territory in NSTEMI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What is troponin?

A

A myocardial protein released into the bloodstream when cardiac myocytes are damaged

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

When do serum troponin levels typically rise?

A

3 hours after MI begins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What are non-ACS causes of a raised troponin?

A

1) Pericarditis
2) Myocarditis
3) Arrhythmias
4) Defibrillation
5) Acute heart failure
6) Pulmonary embolus
7) Type A aortic dissection
8) Chronic kidney disease
9) Prolonged strenuous exercise
10) Sepsis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

How do you manage STEMI?

A

MONAC
1) IV morphine/diamorphine
2) Oxygen - aiming for sats > 90%
3) Nitrates - sublingual GTN spray (for symptom relief)
4) Aspirin PO 300mg (loading dose)
5) Clopidogrel 300mg (or ticagrelor 180mg)
6) Primary percutaneous coronary intervention (PPCI) if eligible
Remember that (particularly in STEMI) time is heart therefore urgent treatment, escalation and delivery of PPCI is critical to good outcomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What should be added onto STEMI treatment if the patient is going on to have PCI?

A

1) Prasugrel (if not on anti-coagulation) or
2) Clopidogrel (if on anti-coagulation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Which dose of aspirin do you give in STEMI?

A

300mg PO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Which dose of clopidogrel do you give in STEMI?

A

300mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Why do you give IV morphine in (N)STEMI?

A

Analgesia + causes vasodilation reducing preload on the heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Which patients are eligible for PCI?

A

1) Present within 12 hours of onset of pain AND
2) Are < 2 hours since first medical contact

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

How do you manage a STEMI in a patient who is stable but PCI is not available within 2 hours?

A

Thrombolysis (alteplase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

How do you manage a patient presenting with STEMI > 12 hours after symptom onset?

A

Pharmacological management

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

How to you manage NSTEMI?

A

BOATMAN
1) Base the decision about angiography and PCI on the GRACE score
2) Oxygen - if sats drop
3) Aspirin 300mg stat
4) Ticagrelor 180mg stat (clopidogrel if high bleeding risk or prasugrel if having angiography)
5) Morphine IV
6) Antithrombin therapy - fondaparinux (unless high bleeding risk or immediate angiography)
3) Nitrates - sublingual GTN spray

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

What dose of ticagrelor do you give in NSTEMI?

A

180mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

When would you give clopidogrel over ticagrelor in NSTEMI?

A

High bleeding risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

When would you give prasugrel over ticagrelor in NSTEMI?

A

If they are having immediate angiography

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

When would you NOT give fondaparinux in NSTEMI?

A

High bleeding risk OR immediate angiography

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Which scoring system is used to make a decision about angiography and PCI in NSTEMI?

A

GRACE score

48
Q

How is the GRACE score used?

A

The GRACE score gives a 6 month probability of death after having an NSTEMI
1) < 3% = low risk
2) > 3% = medium-high risk
3) Patients at medium or high risk are considered for early angiography with PCI (within 72h)

49
Q

How do you manage a patient with NSTEMI at medium or high risk?

A

Early angiography + PCI (within 72h)

50
Q

How do you manage clinically unstable patients with STEMI or NSTEMI?

A

Immediate angiography

51
Q

Which drug is contraindicated in patients with hypotension?

A

GTN

52
Q

What do patients require after initial management of MI once they are stable?

A

1) Echo - to assess functional damage to the heart, esp. LV function
2) Cardiac rehabilitation
3) Secondary prevention medications

53
Q

How do you manage unstable angina?

A

Similar to that of NSTEMI with aspirin for all patients and fondaparinux and early angiography for those at high risk

54
Q

Which imaging investigation is needed post-MI?

A

Echo

55
Q

Why is an echo needed post-MI?

A

To assess functional damage to the heart, esp. left ventricular/systolic function and any evidence of heart failure (should be treated)

56
Q

Which medications are given for secondary prevention post-MI?

A

1) Aspirin 75mg OD lifelong
2) Antiplatelet - ticagrelor or clopidogrel for 12 months (depends on type of stent inserted)
3) Atorvastatin 80mg ON
4) ACEi - ramipril
5) Beta blocker - bisoprolol
6) Aldosterone antagonist for those with clinical heart failure e.g. eplerenone titrated to 50mg OD

57
Q

What type of drug is aspirin?

A

Anti-platelet

58
Q

What does of aspirin is given as post-MI management?

A

75mg OD

59
Q

How long does aspirin need to be taken post-MI?

A

Lifelong

60
Q

What does of atorvastatin is given post MI?

A

80mg (high dose)

61
Q

How long is the second antiplatelet taken post-MI?

A

12 months - clopidogrel 75mg OD or ticagrelor 90mg OD

62
Q

What should patients treated for MI without angiography be considered for?

A

Ischaemia testing - to assess for inducible ischaemia

63
Q

What are complications of MI?

A

1) Ventricular arrhythmia
2) Recurrent ischaemia/infarction/angina
3) Acute mitral regurgitation
4) 2nd or 3rd degree heart block (common)
5) Cardiogenic shock
6) Cardiac tamponade
7) Ventricular septal defects
8) Left ventricular thrombus/aneurysm
9) Left/right ventricular free wall rupture
10) Dressler’s syndrome
11) Acute pericarditis

64
Q

When can ventricular arrhythmias occur post-MI?

A

1) As a consequence of MI
2) During cardiac catheterisation
3) After reperfusion

65
Q

How do you manage ventricular arrhythmias post-MI?

A

1) Most are short-lived and self-resolve
2) If sustained VT or VF occurs - should be treated as per ALS protocols

66
Q

What are the features of recurrent ischaemia/infarction/angina post-MI?

A

1) Occasionally inserted stents can thrombose requiring reintervention
2) New infarcts can occur in different vascular territories (this is less likely now with PCI where all territory are imaged during the procedure)
3) Angina + chest pain can continue for some time after an MI and is more common in NSTEMI patients

67
Q

Why can congestive heart failure occur post-MI?

A

As a consequence of impairment of heart muscle function secondary to ischaemia

68
Q

How should congestive heart failure be treated post-MI?

A

As any other acute heart failure - ventricular function may improve over months as the heart muscle recovers

69
Q

After which type of infarct is heart block more common?

A

Following inferior infarcts - bc RCA supplied the SA node

70
Q

How can heart block be treated post-MI?

A

1) Simple observation - as many will revert back to sinus rhythm
2) Transcutaneous/venous pacing - if symptomatic
3) Permanent pacing - if failing to resolve

71
Q

After which type of MI can left ventricular aneurysm occur and what happens?

A

Aneurysm can occur following an anterior MI where the myocardium can be susceptible to wall stress leading to an aneurysm

72
Q

How does left ventricular thrombus present?

A

May be silent, cause arrhythmias or embolic events

73
Q

How is left ventricular aneurysm diagnosed?

A

1) Definitively on ECHO
2) ECG - may show persisting ST elevation

74
Q

What are the features of left ventricular thrombi?

A

1) Thrombus can form either within an above described aneurysm or around hypokinetic regions of the myocardium
2) Thrombi can embolise causing complications e.g. stroke, acute limb ischaemia and mesenteric ischaemia

75
Q

What is left/right ventricular free wall rupture post-MI?

A

1) Necrosis of the free walls of either ventricle can lead to rupture allowing blood into the pericardial space
2) This leads to a rapid tamponade
3) Normally leads to cardiac arrest/death within seconds

76
Q

What is treatment for left/right ventricular wall rupture?

A

Pericardiocentesis + surgery (but prognosis is v poor)

77
Q

Which valve disorder can occur post-MI?

A

Mitral regurgitation

78
Q

Why does acute mitral regurgitation occur post-MI?

A

Bc of papillary muscle rupture - poor prognosis

79
Q

How does acute mitral regurgitation post-MI present?

A

1) Pansystolic murmur - loudest at apex
2) Severe + sudden heart failure

80
Q

How is acute mitral regurgitation post-MI diagnosed and treated?

A

Echo - may require surgical correction

81
Q

What are the features of ventricular septal defect/rupture?

A

1) Interventricular septal rupture is a short-term complications of myocardial infarction
2) Rupture caused by an anterior infarct is generally apical and simple
3) Rupture caused by an inferior infarct is generally basal and more complex
4) Without reperfusion, septal rupture typically occurs within the first week after the infarction

82
Q

How does ventricular septal defect/rupture present?

A

1) SOB
2) Chest pain
3) Heart failure
4) Hypotension
5) Harsh, loud pan-systolic murmur along the left sternal border
6) Palpable parasternal thrill

83
Q

What does a harsh, loud pan-systolic murmur along the left sternal border indicate?

A

Ventricular septal rupture/defect (post-MI)

84
Q

How do you diagnose ventricular septal rupture/defect?

A

Echo

85
Q

How do you manage ventricular septal rupture/defect?

A

Emergency cardiac surgery

86
Q

What is Dressler’s syndrome?

A

Post-infarction pericarditis

87
Q

How does Dressler’s syndrome present?

A

Persistent fever + pleuritic chest pain 2-3 weeks-few months after MI
- Can also present with features of pericardial effusion (has become relatively uncommon since introduction of PCI)

88
Q

Is pericarditis immediately following MI Dresser’s syndrome?

A

No

89
Q

How do you manage Dressler’s syndrome?

A

1) High dose aspirin
2) Symptoms usually resolve after several days

90
Q

What are post-MI signs on ECG?

A

1) Pathological Q waves in relevant leads
2) T wave inversion

91
Q

What is the chest pain like in angina?

A

Typical = 3 features:
1) Constriction like pain in chest/neck/arm/jaw
2) Brought on by physical activity
3) Alleviated by rest or GTN within minutes
Atypical = 2 out of 3 features

92
Q

What are first-line investigations for stable angina once atypical or typical angina pain is suspected?

A

1) ECG
2) Routine bloods e.g. FBC to exclude anaemia
3) TFTs - to exclude hyperthyroidism which can exacerbate angina

93
Q

Which two non-cardiac conditions can exacerbate angina?

A

Anaemia + hyperthyroidim

94
Q

What is the first line diagnostic investigation for stable angina?

A

CT coronary angiography

95
Q

When is CT coronary angiography indicated?

A

1) Atypical or typical angina pain
2) ECG showing ischaemic changes in chest pain with < 2 angina features

96
Q

What are second line functional imaging investigations that can be done if CT coronary angiography is inconclusive in stable angina?

A

1) Myocardial perfusion SPECT
2) Stress Echo
3) MRI for regional wall motion abnormalities

97
Q

What is the third line investigation of stable angina if there are inconclusive results from non-invasive testing?

A

Coronary angiogram

98
Q

What is conservative management in angina?

A

Optimising risk factors for CVD:
1) Smoking cessation
2) Glycaemic control
3) Hypertension
4) Hyperlipidaemia
5) Weight loss
6) Alcohol intake
Prevention medication - aspirin, statin

99
Q

What is the first line management if stable angina?

A

1) Lifestyle measure (conservative)
2) Prevention medication - aspirin, statin (conservative)
3) GTN + beta-blocker OR rate-limiting CCB e.g. verapamil

100
Q

What is first line medical management in stable angina?

A

GTN + beta-blocker OR rate-limiting CCB e.g. verapamil/diltiazem

101
Q

What advice needs to be given to patients starting GTN?

A

1) Side effects = headaches, flushing, dizziness
2) Take another dose if pain has not subsided after 5 mins
3) Emergency help should be sought if the pain has not subsided after 2 doses of GTN - may indicate acute coronary syndrome

102
Q

After how many doses of GTN should a patient call the ambulance bc of the risk of ACS?

A

2 doses ineffective

103
Q

What is first line medical management of stable angina if a patient is unable to tolerate a beta blocker?

A

Rate-limiting CCB e.g. verapamil

104
Q

What is first line medical management of stable angina if a patient is unable to tolerate a Rate-limiting CCB?

A

Beta blocker

105
Q

Which medications should be considered for first line stable angina medical management if the patient is unable to tolerate or is contraindicated to a beta blocker or rate-limiting CCB?

A

1) Long-acting nitrate e.g. Isosorbide Mononitrate
2) Ivabradine
3) Nicorandil
4) Ranolazine

106
Q

What is second-line medical management for stable angina?

A

Beta blocker AND long-acting dihydropyridine CCB e.g. amlodipine

107
Q

What are the rate-limiting/non-dihydropyridine calcium channel blockers?

A

Verapamil, diltiazem

108
Q

What are the long-acting dihydropyridine calcium channel blockers?

A

Amlodipine, nifedipine extended release

109
Q

What is third line management of stable angina?

A

1) Coronary angiography - unless contraindicated as PCI may be required
2) Consider ACEi for patients with diabetes and hypertension

110
Q

Which two medications do you not prescribe together for treatment of stable angina?

A

Beta blocker + dihydropyridine CCB e.g. bisoprolol and amlodipine

111
Q

When should a third medication be added to treatment of stable angina?

A

If the patient is symptomatic despite 2 anti-anginal drugs

112
Q

What are revascularisation treatments?

A

CABG or PCI

113
Q

When should patients with stable angina be considered for revascularisation (PCI or CABG) - indications for CABG?

A

Symptoms are not satisfactorily controlled on optimal medical treatment AND
1) There is complex 3 vessel disease OR
2) There is significant left main stem stenosis

114
Q

What is the advantage of PCI over CABG?

A

More cost effective

115
Q

In which patients does CABG have a mortality advantage over PCI?

A

1) > 65 years
2) Diabetes
3) Anatomically complex 3 vessel disease - with or without left main stem stenosis

Stage 3 (61 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions