Cardiology Flashcards
Endocarditis
eti, sxs
MC Native Valve infx - Mitral - Strep viridans, S aureus, Enterococcus
IVDU - S aureus in tricuspid; Prosthetic - S. aureus or fungal if w/in 2 mos of implantation
Sxs:
- Fever,
- non spec sx - dyspnea, CP
- Murmur
- Janeway lesions - painless macules on palms and soles
- Roth spots - retinal hemorrhages w/ pale centers
- Petechiae
- Splinter hemorrhages
Endocarditis
dx, tx
Modified Duke Criteria
Major
- bacteremia 2+ blood culture
- Echo w/ evidence of vegetation
- Newly dx valvular regurgitation
Minor
- RFs - IVDU, indwelling cath, weird valvular morphology
- Fever > 38C or 100.4F
- Vasc or embolic phenomena - Janeway lesions
- Immunologic phenom - Osler nodes (ouch), Roth spots, acute GMN
- Positive blood cultures not meeting major criteria
Tx
- Acute/Native Valve
- Nafcillin + Gentamicin; Vanco if MRSA+
- Subacute (HACEK organisms)
- Pencillin or Ampicillin + Gentamicin
- Vanco if MRSA+
- Prosthetic valve
- Vanco+Gentamicin + Rifampin (For S aureus)
- Fungal
- Ampho B for 6-8 wks
Stable Angina
Angina brought on by physical activity, emotional upset - relieved w/ stress in a few mins (<30mins)
Levine’s sign
Dx
- EKG w/ temporary ST depression, T wave depression or inv
- Stress test - exercise or pharmological with adenosine or dipyridamole
- Coronary angio - gold std***
Printzmetal Angina
vasospasm - smooth m contractions
Eti - cocaine, smoking, > 50yo, F
non-exertional CP
cyclical - usu in the morning
Dx:
- EKG - ST or T waves elevations, Inverted U waves
- Normal trop and CKMB
Tx - CCBs
Unstable Angina
Previously stable & predictable => more freq and intense
new onset or severe or worsening angina, occurs at rest
Dx -
- EKG - ST depr or T w inv
- Normal CKMB and trop
Tx
- progression to MI if untreated
- Nitroglycerin and morphine
- Stress test - if cath or revasc necessary
NSTEMI
prolonged crushing CP; more severe and wider radiation; R->L arm or upper back
Dx
- EKG w/ ST depr or T wave inv
- Elevated Trop or CKMB or BNP
- Cardiac Cath to determine tx
- PCI or CABG
STEMI
Leads
- V1, V2, V3, V4- Anterior → LAD
- V1, V2 - Septal
- I, aVL, V5, V6 - Lateral → Circumflex
- II, III, aVF - inferior → RCA
A NEW LBBB = STEMI
Dx
- ST elevation >/= 1 mm in at least 2 anatomically contiguous leads + reciprocal changes in opposite leads
- Ele Trop > 0.08
- Appears 3-12 hrs
- Peaks 24-48 h
- Lasts 5-14 days
- Ele CK-MB
- Appears 3-12 hrs
- Peaks 24 h
- Lasts 2-3 days
NSTEMI/STEMI
Treatment
Reperfusion is KEY - done w/in 12 hrs of onset
Immediate Tx in ED
- Morphine
- O2
- ASA 325mg
- Nitroglycerine subling x3 q5m
- BB
- Statin
- ACEI/ARBS
PCI
- best within 3 hrs
- > thrombolytics
Thrombolytics/Fibrinolytics
- use if PCI is not available
- Alteplase (tPa) - activates plasminogen to destroy clots
- Streptokinase - less effective than tPa, less chance of ICH
Maintenance
- Antiplatelet therapy
- Aspirin - inhibits plt activation and aggregation
- P2Y12 inhibitor - Plavix/clopidegrol, Ticagrelor, Prasugrel
- Anticoag
- Unfrc Heparin - binds to antithrombin
- LMWH - better for DM
- Anti-ischemic therapy
- BB - decr symp drive
- Nitrates - venodilation
- CCB - verapamil/diltiazem - decr contractility
Pericarditis
idiopathic or viral - restrictive pressure on heart
Sxs:
- Dyspnea, fatigue, weakness
- Sharp, pleuritic substernal CP => relieved by sitting upright or leaning forward
- Friction rub
- edema
Dx
- ele WBC
- Diffuse ST seg elevations - EKG
Tx
- NSAIDs or Aspirin x 7-14d
- Colchicine 2nd line
- CS if sxs > 48 or refractory
Pericardial Effusion
2/2 to pericarditis, uremia, cardiac truam
Sxs:
- painful or painless, depending on rate of effusion
- cough
- dyspnea
- pressure
Dx
- EKG - electrical alternans, non-spec T wave changes, low QRS voltage
- Echo - fluid surrounding heart
Tx
- Observe is small
- Pericardiocentesis if + tamponade or large effusion
Cardiac Tamponade
fluid compromises refilling - collapsed R ventricle (weakest wall) and impairs CO
Sxs:
- Pulsus paradoxus - > 10 mmHg decrease in systolic when pt inspires
- Tachycardia, Tachypnea
- Narrow pulse pressure (180/130)
-
Beck’s Triad***
- JVD
- Muffled heart sounds
- Hypotension
Tx - pericardiocentesis immediately
Peripheral Artery/Vascular Disease
MCC atherosclerosis
Sxs:
- Intermittent claudication on lower leg pain, relieved by rest
- Develops to pain at rest
- weak femoral or distal (popliteal/TP/DP) pulses
- Aortic, iliac, or femoral bruit present
- Skin changes
- shiny
- atrophic
- loss of hair
- be wary of acute arterial occlusion - 6Ps
Dx
- Doppler US - eval
- ABI - BP in upper and lower extremities
- <0.9 = severe disease
- normal is >1.2
- Angiography - gold std
- stenotic sites
Tx
- smoking cessation
- control HTN, DM2, HLD
- Aspirin/ plavix
- stenting if stenosis > 70%
- Cilostazol - relieve w/ walking
Dilated Cardiomyopathy
Systolic dysfunction => ventricular dilation => decreased contractial function => reduced CO
Eti:
- MC in 20-60yo, M, idiopathic 50%
- viral myocarditis - Enteroviruses (Coxsackie B), Chagaz dz
- Toxic - etoh abse, cocaine, doxorubicin, radiation
Sxs:
- systolic HF - fatigue, DOE
- mitral or tricuspid regurg
- lateral displaced PMI
- S3 if
Dx:
- CXR - enlarged heart, pulm edema, pleural effusion
- Echo - LV dilation, decr EF, regional or global LV hypokinesis
Tx:
- HF Tx - ACEI, diuretics, BBS, Digoxin, NA restrictionn
- ICD if EF < 30-35%
DDx
- Takotsubo CMO - broken heart syndrome, apical L ventricular ballooning d/t catecholamine surge
Hypertrophic Cardiomyopathy
Hereditary - Autosomal Dom, early MI death, young athletes
Hypertrophied Ventricular septum = Impaired ventricular relaxation/filling
Sxs:
- Dyspnea, Angina, Syncope - esp during exertion
- Sudden cardiac death - due to V fib
- S4 if outflow obstruction present
- Harsh cres-decres murmur at LLSB
- incr murmur intensity with decreased venous return (Valsalva or standing)
Dx:
- Echo - asymmetrc wall thickeys > 15mm, small LV chamber size
- EKG - LVH, atrial enlargement
- CXR - cardiomegaly
Tx:
- Counseling - avoid dehydration and extreme exertion/exercise
- BB - first line, CCB
- Avoid Digoxin (incr contractility), Nitrates and diuretics (decr’s LV volume)
- Surgical - myomectomy - definitive if refrc to medical tx
- ICD For high risk
*
Restrictive Cardiomyopathy
Impaired diastolic relaxation - stiff ventricles decreases filling
Eti - infiltrative diseases - Amyloidosis MCC, Sarcoidosis, hemachromatosis, scleroderma, chemo, XRT
Sxs:
- RS HF more common
- Kussmaul’s sign - JVP incr with inspiration, Hepatomegaly, perip edema
Dx:
- Echo - usual normal systolic contraction
- Speckled appearance - infiltrative disorder
Tx:
- Na restriction, caution diuretics
- treat underlying disorders
Atrial Fibrillation
Conduction Disorders
Irregularly Irregular rhythm - SVT
MCC - mitral valve stenosis, hyperthyroidism
Sxs:
- SOB, Chest Pain, Dizziness, Fatigue
- Irregular pulse
Dx:
- EKG - Irregular irreg rhythm
- Atrial rate >140bpm
- No discernable P waves
- variable and irreg QRS
Tx:
- Rate control - BB, CCB, or digoxin (for CHF or hypotension)
- anticoag - warfarin or DOACs if CHADsVASc >/= 2
- CHF
- HTN
- > 75yo
- Stroke, TIA, Thrombus
- Vasc dz
- Female
- Unstable AF or new onset AF < 2 d - cardiovert
- > 2 days get TEE To r/o clot
Atrial Flutter
Conduction Disorders
Atrial focus of ~300 bpm
Sxs:
- SOB, dizziness, fatigue
Dx:
- EKG - Saw tooth pattern, regular rhythm
- Atrial rate 240-320bpm
- Ventricular 150bpm
Tx:
- Rate control BB, CCB, Digoxin*
- Anticoag if CHAD Vasc >/=2
- Warfarin or DOAC