Cardiology Flashcards
1
Q
Signs of asymptomatic ASD
A
Wide FIXED SPLIT S2
Pulmonary flow murmur (ESM RUSE)
May get tricuspid flow murmur (mid diastolic)
Secundum ASD >2cm often symptomatic
2
Q
Syndrome associated with ASD primum?
A
Downs/T21 (endocardial cushion defect)
3
Q
Syndrome associated with secundum ASD?
A
Holt Oram Syndrome (a/w TXB5)
4
Q
ECG in secundum ASD?
A
- 2 Ps - peaked P waves (Lead 2/V2_ and long PR
- 2 Rs - RAD and RBBB (incomplete) / rSR’ pattern
5
Q
What is the valvular issue associated with primum ASD??
A
Cleft anterior leaflet of MV
6
Q
What gene may be involved in primum ASD development?
A
Tbx1 (a/w 22q11)
7
Q
What genetic syndromes are associated with ASD?
A
Down most common Holt-Oram syndrome Noonan syndrome Ellis van Creveld syndrome Cri du chat Kabuki syndrome Trisomies 13,18 Chondroectodermal dysplasia
8
Q
What are the long term complications of untreated ASD?
A
R sided volume overload - RVH Pulmonary artery hypertension Increased PVR Paradoxical embolisation/stroke SVT, AF, flutter
9
Q
What problems do retinoids cause in pregnancy and why?
A
Retinoids help signal embryonic body patterning therefore variety effects in
