Cardiology Flashcards
Risk factors for ACS?
Previous IHD DM Hyperlipidaemia HTN Family history Smoking OCP Obesity Long term use of NSAIDs
Management of infarction?
Primary PCI if door to balloon time is <90minutes
Thrombolysis if not - alteplase and then delayed PCI
Complications of infarct?
Ventricular arrhythmias Papillary muscle rupture --> MR Bradyarrhythmias Cardiac failure Further ischaemia or reinfarction
Long term management of infarction
Early revascularisation Aspirin and ticagrelor/clopidogrel for >1yr Statin - LDL <1.8 Beta-blockers HR <70 ACE-Is max dose Spirolactone/epleronone Coronary bypass grafts
Secondary prevention of infarction?
Weight reduction Exercise 3x/week Lipid reduction Smoking cessation HTN management <130/80 Cardiac rehabilitation
Causes of Left heart failure?
Volume overload - AR, MR, PDA
Pressure overload - HTN, AS
Myocardial disease - IHD and dilated CM
Causes of Dilated CM?
Idiopathic EToL Viral Familial Myocarditis Tachycardia induced Peripartum Neuromuscular disease Connective tissue disease Haemochromatosis Sarcoidosis Drugs - Doxirubicin Radiation
Causes of right heart failure?
Volume overload - ASD, TR
Pressure overload - PS, pulm. HTN
Myocardial disease - CM secondary to LVF, right ventricular infarction
Acute control of Systolic Heart Failure?
Decrease physical activity
Control fluid retention - diuretics, low-salt diet, fluid restriction
Daily weights
RAAS blockade - ACE-Is or ARB and neprilysin
Spironolactone
Catecholamine blockade - Beta-blockade
IV inotropes
Long term control of Systolic Heart Failure?
Treat Iron deficiency Prevent Arrhythmias - Defibrillator Bi-ventricular pacing - QRS>150 LVAD as a bridge to transplant Heart transplant
Treatment of Diastolic heart failure?
Beta-Blockers
Small doses of diuretics
Control HTN
Familial Hypercholesterolaemia?
Defect or low LDL
Autosomal dominant
10x elevation in serum cholesterol
MIs at 30-40yrs
Find out about LDLs and HDLs
? history of pancreatitis - hypertriglyceridaemia
EtOH consumption, hypothyroidism, OCP use
Xanthomas on exam
Treat with Statin, ezetimibe, gemfibrozil
PSCK9 inhibitors
Diet
Aim for Hypertension treatment?
Nil issues - <140/90
CVD or DM - <130/80
Investigations for HTN:
ECG - ? LVH
Urine for protein
Hypokalaemia –> renin-aldosterone levels
Ct angiogram - renal arteries
Sleep study - OSA
Urinary catecholamines - Phaeochromocytoma
Ix for cushings syndrome
Conservative BP management?
Weight reduction Exercise EtOH reduction Salt reduction OSA management
Medication BP management?
Thiazide diuretics ACE-Is Calcium channel blockers Beta blockers Spironolactone
Evaluation for heart transplant?
- History and examination
- Body weight
- Cardiac assessment:
- GHPS for EF
- TTE - valves and ? thrombus
- Coronary angiogram - ?IHD
- 24hr holter for ? arrhythmias
- Right heart catheter ? pulm HTN - CONTRAINDICATION FOR TRANSPLANT - HLA tissue typing
- CXR and lung function tests
- FBC, EUCs, LFTs, cholesterol, BSLs ESR and Coagulation sties
- Serology - HAV, HBV, HCV, HIV, CMV, EBV, HSV, TPG
- Psych, renal and dental assessments if required
- Social work referral
Heart transplant history?
Cause of heart failure
Previous IHD symptoms ? previous angiograms
Symptoms pre-surgery
Exercise tolerance pre-surgery
Treatments pre-surgery - drugs, defibs, LVAD
Problems with the surgery
Endomycardial biopsies
Immunosuppressive medications
Episodes of rejection? Treatment with methylpred? ? MTX or muromonab
Complications of immunosuppression
Angiograms post op
Effect on current life
Cancers - skin, lymphoproliferative, cervical
Heart transplant examination?
Median sternotomy scar Signs of pericarditis - ? rejection Neck scars - endomyocardial biospy ? Steroid effects - cushingoid appearance ? signs of infection
Heart transplant investigations?
Endomyocardial biospies FBC, EUCs, LFTs, BSLs Drug levels Urine protein and creatinine CXR ECG and TTE GHPS
Discussion points for heart transplant?
Rejection - biopsy and pred Infection risk from immunosuppression - fungal, viral and bacterial Cancer risk - skin, PTLD, cervical Hyperlipidaemia Hypertension Myocardial infarction Prognosis
Causes of AF:
AGE HTN Mitral valve disease IHD Recent surgery ASD WPW syndrome Recent EtOH binge PE Thyrotoxicosis Exercise
Investigations for arrhythmias?
Resting ECG EPS TTE TFTs Angiogram
Indications for PPM insertion?
Intermittent or permanent complete heart block
Intermittent or permanent 2nd degree heart block with symptomatic bradycardia
Sinus node dysfunction with symptomatic bradycardia
Indications for implanted cardioverter-defibrillators?
Confirmed VT or VF
Symptomatic long QT
EF <30% with QRS >150
Assessment of patients with frequent activations of a defibrillator?
Check device programming
Exclude new ischaemia
Introduce or increase anti-arrhythmic treatment
Consider VT ablation
Management principles of AF?
Maintain SR
Control the HR
Protect from embolic events
CHA2DS2-VASc?
Congestive HF = 1 HTN = 1 Age 65-74yrs = 1 Age >75yrs = 2 DM = 1 Stroke or TIA = 2 Vascular disease = 1 Sc = female = 1
Male patient score of 1 = anticoagulant
Female patient score of 2 = anticoagulant