Cardiology 2 Flashcards
Thiazide
Diuretic
Diuretics
Inhibit sodium and water retention, this reduces plasma volume which decreases preload and decreases wall stress
Loop
Diruretic
Glyceryl trinitrate
Vasodilator \+++ veins \+ arteries Big decrease in preload Small decreases in aftelaod
Sodium nitroprusside
Vasodilator
Breaks up into nitric oxide automatically- large effect on veins and arteries. Large decreases in pre and after loads
Ace inhibitor
Vasodilator
Blocks formation of angiotensin 2
Medium effect on veins and arteries, medium effect on pre and afterload
ARB angiotensin receptor blocker
Vasodilator
Med effect on veins and arteries
Med effect on pre and afterload
Phosphodiesterase inhibitor
Vasodilator
Med effect on veins and arteries
Med effect on pre and afterload
Hydralazine
Vasodilator
Also inhibits superoxide formation, very effective when given with isosorbide dimitrate
Digoxen
Inhibits sodium potassium pump
Muscle tension is proportional to intracellular sodium levels
75% absorption normally
10% in patients with digoxin inactivating bacteria
Co treatment with antibiotics and lead to toxcity
2/3 elimination unchanged in kidney
Renal failure can lead to toxicity
Glycoside in order of longest to shortest acting
Digitoxin, digoxin, ouabain
Digitoxin ionic interactions
Potassium inhibits digoxin binding to ATP ase
Calcium potentiates digoxin effects
Magnesium attenuates digoxin effects
Metroplol
Cardio selective beta blocker
Beta 1 antagonist
Carvedilol
Beta blocker for both beta 1 and 2 receptors
Cardiomegely
Enlarged heart