Cardiology Flashcards
Which has the highest sensitivity for ventricular arrhythmias? Which one can’t be evaluated in real time?
A) ECG strip
B) Continuous ECG with q1min technician assessment
C) Recorded continuous telemetry
D) Holter
D Holter – most sensitive but can’t be eval in real time, if that’s important (ex: post splenectomy) then use recorded continuous telemetry
JVECC 2021 Teslenko
Which two breeds can have a left shift of the QRS mean electrical axis on ECG, even when healthy?
Pugs, Eng bulldogs
JAVMA 2023 Cipone
An elevation in which biomarker(s) is/are associated with worse prognosis in dogs with SIRS?
A) NT-proBNP
B) Cardiac troponin T (CTnT)
C) Both
D) Neither
B
May be due to “cardiac hibernation” (maladaptive systolic and diastolic ventricular dysfunction in septic patients)
JVECC 2019 Gommeren
Which are good point of care tests to discriminate R CHF vs other cause of nonhemorrhagic abdominal effusion?
NT-proBNP
Cardiac troponin I (CtnI)
GB wall edema
Distension of hepatic veins, CVC
NT-proBNP
Distension of hepatic veins, CVC
JVIM 2023 Morey
12yr FS DLH with noninvasive workup consistent with IBD vs LSA. She has a heart murmur grade 2/6 parasternal systolic. The owner declines any additional big workup (echo, scope) in favor of empiric steroids.
What would be a good practical test to monitor cardiac tolerance of steroids?
Baseline and follow up NT-proBNP
JVIM 2020 Block
What is the relative sens/spec (low, mod, high) of NT-proBNP to detect heart disease in clinically healthy cats?
How does the presence of a heart murmur affect these?
In general, low sens, high spec
With HM, moderate sens, high spec
So, not a good screening test (false negs) BUT positives can be trusted
JVIM 2021 Lu
12yr MI Yorkie with a new heart murmur grade 3/6 LAS. Which is a good screening test for subclinical MVD (ACVIM Stage B1, B2)?
Which one(s) scale with disease severity?
Which one(s) would be helpful if the dog were in respiratory distress and you wanted to rule out CHF (Stage C)?
ANP
cTnI
ACE2
Subclinical MVD - ANP only
Scale with MVD severity - ANP, cTnI, ACE2
Screen for CHF - ANP and cTnI
JAVMA 2020
JVIM 2023 Hammond
A) Dogs
B) Cats
C) Both
D) Neither
CTnI is a good screening test for subclinical heart disease (MVD or HCM, respectively) in _____
CTnI in critically ill patients is associated with nonsurvival in ____
Subclinical heart disease: Cats only
**Exception: new high sensitivity assay has moderate sense/spec for preclinical DCM dobies
Prognostic in critical illness: Dogs only (high CTnI is common in cats, but not prognostically informative)
JVIM 2019 Hertzsch
JVIM 2019 Kluser
15yr FS DSH that you manage for CKD IRIS Stage 3. She has a new heart murmur grade 3/6 LAS. Her CTnI was elevated, but her echo was normal. Explain.
Can see high CTnI due to renal dysfunction (not sure if maybe it’s GFR dependent?)
JFMS 2019 Langhorn
Name at least 3 non-cardiac diseases that can increase CTnI.
GDV
Babesia
Kidney disease
PHT
SIRS
JVIM 2019 Kluser
11yr FI chihuahua with fever of unknown origin and HM 3/6 LAS. CTnI was severely elevated. What does this suggest?
A) Physiologic murmur
B) MVD Stage C
C) Endocarditis
D) Correlates only with severity of heart disease, not etiology
E) Can be elevated due to inflammation
C – cTnI >0.6 is sens 52/spec 100 for endocarditis (compared to MVD Stage B and immune mediated disease)
JVIM 2021 Kilkenny
Which breed tends to have larger LV volumes +/- wall thickness?
A) Barrel chested breeds
B) Giant breeds
C) Toy breeds
D) Sighthounds
D
JVIM 2020 Esser
JVIM 2021 Wess
JVIM 2023 Stepien
POCUS is helpful to dx CHF in _______ presented in respiratory distress.
A) Dogs
B) Cats
C) Both
D) Neither
Cats only, esp if also high NT-proBNP.
In dogs, did not provide more for ddx list than hx and PE.
JVECC 2020 Hezzell
JVIM 2019 Ward
True or False: Gabapentin is an acceptable sedative for echocardiogram, as it will not alter any of the variables/measurements.
True
JFMS 2022 Veronezi
JFMS 2022
What is the significance of:
–High effective arterial elastance (Ea)
–High Ea/Ees
What is the gold standard way to measure? What is more practical?
High Ea: incr total arterial load of the LV, potentially due to high BP (afterload), HR, or both
High Ea/Ees: worse px in MVD dogs
Gold standard = cardiac catheter, pressure volume loops
But, can use echo to estimate
JVIM 2021 Osuga
What is the indication for transesophageal echo?
Procedure monitoring:
PDA ligation or coil
PV stenosis and balloon valvulopasty
JVIM 2022 Stoner
How do you calculate:
MHS (manubrium heart score)
Long MHS
Short MHS
Cardiac sphericity index
What would you expect with R and L sided heart disease?
MHS = heart length + (heart width/manubrium length)
Long MHS = heart length/ML
Short MHS = heart width/ML
CSI = heart width/heart length
R heart disease: high CSI, high short MHS with normal long and overall MHS
L heart disease: high short, long, and overall MHS
JAVMA 2020 Mostafa
What is subclavian steal syndrome?
Occlusion or stenosis of subclavian aa –> retrograde bloodflow in downstream ipsilateral vertebral artery –> vessel dilation, can potentially compress spinal cord and cause neck pain
JAVMA 2021 Shimbo
Doppler BP in cats:
–Which tends to read higher, forelimb or tail?
–Is it a big enough difference to affect clinical decisions?
Tail, medial 15-20mmHg higher than forelimb but too variable really to apply a correction factor.
Can affect which category they go in, usually normo vs HYPERtensive…not HYPOtensive (incl in sick cats).
JFMS 2019 Zeugswetter
JVECC 2021 De Rosa
Which setting offers the most consistent BP reading in cats?
A) Owner present
B) Owner absent
C) In carrier
D) On exam table
C
JVIM Hanas 2021
One study found that Birman cats have (higher) (lower) (no difference in) BP compared with other cat breeds.
That same study found that cats with outdoor access have (higher) (lower) (no difference in) HR compared with indoor only cats.
Birman - lower BP
Outdoor access - lower HR
JVIM Hanas 2021
Which predispose to HIGHER BP in cats? Select all that apply.
A) Weight
B) BCS
C) Age
D) Stress
E) Sitting
F) Laying down
Age, stress, sitting
JFMS 2021 Knies
How could you potentially use AUS to differentiate situational vs persistent hypertension?
Measure aortic strain (AoSt) which is based on aortic diameters, can look at level of the iliac arteries and at kidneys
AoSt = [(systole-diastole)/diastole]x100
Lower AoSt = less elasticity, r/o secondary to chronic SHT and smooth muscle hypertrophy
JVIM 2020 Corda
How might the following affect retinal vessel diameter?
Age
SHT
Older –> SMALLER retinal vessels (but does not correlate with BP)
Some SHT cats controlled on amlodipine will have shrinking (normalizing?) retinal vessels
JFMS 2021 Enache
Which is true?
A) BP should be monitored in all older cats, since early detection of SHT improves long term outcome.
B) BP should be monitored only in cats with risk factors for SHT
C) BP should only be monitored in cats with CS or biochemical abnormalties due to SHT
D) Early symptomatic treatment of SHT (ex: amlodipine) does not affect outcome
A
JVIM 2019 Conroy
Which is true about telmisartan to treat SHT in cats?
A) It is safe, relatively effective, and durable
B) It is effective but there is significant risk for hypotension
C) It is effective but there is significant risk for AKI
D) It is effective but GI side effects are common
E) It is initially effective but aldosterone escape occurs at median 1mo
A) Well tolerated, relatively effective (half of cats BP <150 at 1mo), durable
JVIM 2019 Coleman
JFMS 2019 Coleman
2019 Glaus
What is the most common underlying cause for hypertensive emergencies in dogs and cats?
Two most common CS?
Overall survival rate? How did species affect this?
AKI
Seizures > blindness
Half; we need a better way to recognize and treat
JSAP 2022 Beeston
Which ACE enzyme is involved in the alternate (protective) RAAS pathway? Which organs in the body is it primarily found (2)?
ACE2
Renal tubular epith»_space;> left ventricle
JVIM 2019 Larouche-Lebel
List at least 3 causes of diuretic resistance.
Poor GI absorption
Decr renal tubular transpofrt
Loop of Henle atrophy
RAAS activation
JVIM 2020 Adin
Which electrolyte can help differentiate MVD stage C vs D?
Low Cl –> more common in stage D
Possibly d/t higher diuretic dose (1:2 Na:Cl loss), diuretic resistance, RAAS, ADH, water retention
Note:
Corrected Cl = (mid ref range Na/measured Na) x measured Cl
Only stage D dogs (not B1, B2, compensated CHF dogs) have corr Cl > measured Cl, indicating water excess
JVIM 2020 Adin
JVIM 2020 Adin
Which is true about dogs with ACE polymorphism?
A) Tend to have higher baseline RAAS activity
B) Tend to have more aldosterone breakthrough
C) Tend to be resistant to ACEi
D) Tend to be resistant to spironolactone
E) Does not appear to affect RAAS
B – these dogs may particularly benefit from spironolactone
JVIM 2020
Which results in more alternative (protective) angiotensin peptides in dogs and cats, and one potential mechanism why?
ACEi
ARB
ARB
ACE2 shunts BOTH AT1 and AT2 to the alternative pathway. But, with ACEi, ACE doesn’t work –> no AT2 –> less substrate for ACE2.
JVIM 2020 Laroughe-Lebel
JVIM 2020 Huh