Cardio: Pharmacology of CHF

Question 1

• In CHF, what happens to SV and EDV?
• How does the frank-starling curve change with:
  
  • A positive inotrope
  • A negative inotrope
  • CHF
  • CHF with treatment such as Digoxin

Answer 1

Question 2

What are the three major hemodynamic clinical manifestations of CHF?

Answer 2

Question 3

Where does each drug fit in this figure

• • inotropes
• vasodilators
• ACE inhibitors
• Diuretics

Answer 3

Question 4

What are the ways to treat CHR without Rx?

What drugs can you use to treat CHF?

Answer 4

Question 5

Cardiac Glycosides

• These are used to treat A-fig but are prodysrhythmic. What do they do to:
  
  • Vagal Tone
  • PR interval
  • APD
  • ST segment
• MOA
  
  • What do they inhibit

Answer 5

Question 6

Cardiac Glycosides

• What do these do to:
  
  • EDV, ESV
  • Pulmonary and Systemic Venous pressure
  • Coronary blood flow
  • Preload, Afterload, HR
  • Renal Artery Resistance

Answer 6

Question 7

Cardiac Glycosides

• What do you need to monitor when prescribing this drug?
• What are the ADRs for this drug?

Answer 7

Question 8

Correction of Adverse Elevations in Plasma Digoxin

• What 2 agents can reverse digoxin poisoning?

Answer 8

Question 9

Isoproterenol (Isuprel)

• What receptor does this act on?
• What does it do to calcium?
• What does it do to contractility and HR?
• When do you use it?

Answer 9

Question 10

Dopamine

• What happens with a low dose?
• What happens with a high dose?

Answer 10

Question 11

Dobutamine

• This drug has a similar structure to dopamine. However, what receptors does it have less of an effect on?
  
  • What does this do to contractility?
• When is this drug indicated?

Answer 11

Question 12

Phosphodiesterase inhibitors

• What two drugs fall under this class for use in CHF?

Answer 12

Question 13

What major groups of vasodilators can you use in CHF?

What kind of drug to you generally avoid?

Answer 13