Cardio Pharm- HTN Flashcards
Major options for HTN treatment
ACE inhibitors/ARBs
Thiazide diuretics
calcium channel blockers
beta blockers
which medications are best for young, white patient
ACE inhibitor and Beta Blockers
which medications are best for older patients, or black patients
thiazide diuretic and calcium channel blockers
ACE inhibitors
first line of agents
heart failure pts with ST elevation MI diabetes systolic dysfunciton patient with CKD
ACE inhibitors MOA
comp. inhibitor of angiotensin converting enzyme in lung
prevents conversion of Angiotensin I and Angiotensin II
potent vasoCONSTRICTOR
ACE inhibitors SE
cough
angioedema
hypotension
hyperkalemia
ACE Inhibitor CIs
patient with prior history of angioedema
concomitant use with aliskirin (Rasilez)
drug example of ACE inhibitor
Lisinopril (Zestril)
ARBs indications
similar indications as ACE inhibitors
but it is used for those who don’t tolerate ACE inhibitors
ARBs MOA
blocks vasoconstrictor and aldosterone secreting effects of angiotensin II
side effects of ARBs
hypotension
hyperkalemia
ARB CI
concomitant use with aliskirin (Rasilez)
ARB example drug
Iosartan (Cozaar)
Thiazide Diuretics
indications
HTN in black, elderly patient
Thiazide diuretics MOA
inhibits Na reabsorption in distal tubules
increases excretion of sodium and water as well as potassium and hydrogen ions
Thiazide diuretics SE
hypokalemia
thiazide diuretics CI
sulfa drugs, anuria
thiazide diuretics drug example
hydrochlorothiazide
calcium channel blocker
indications
no absolute indications
dihydropyridine MC
calcium channel blocker ex.
Amilodipine (Norvasc)
calcium channel blocker
MOA
directly acts on vascular smooth muscle to produce peripheral arterial vasodilation reducing peripheral vascular resistance and BP
calcium channel blocker
SE
peripheral edema
pulmonary edema
calcium channel blocker CI
MI/angina
hypotension
peripheral edema
beta blocker MOA
inhibitor of beta adrenergic receptors
