Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CardioRenal I > Cardio Pharm: Autonomic Drugs > Flashcards

Cardio Pharm: Autonomic Drugs Flashcards

1
Q

Epinephrine selectivity

A

a1 agonista2 agonist B1 agonistB2 agonist(Mixed alpha beta receptor agonist)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Epinephrine uses

A

1: drug of choice for anaphylactic shock 2: prolong duration of local anesthetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Describe how epinephrine acts in anaphylactic shock

A

1: Supports BP (increased vasoconstriction -a1, decreased fluid loss and edma- a1, increased cardiac output- increased HR and contractility- B1)2: Supports breathing (bronchial smooth muscle relaxation - B2, decreased mucous secretion- a1, decreased pulmonary edema- a1) 3: inhibit release of mediators of anaphylaxis (B2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Norepinephrine selectivity

A

a1 a2 B1 (mixed alpha beta agonist)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Norepinephrine

A

a1- vascular resistance B1- increased cardiac contractility(both work together to increase bp)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Norepinephrine uses

A

1: Cardiogenic shock 2: Septic shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Side effects of mixed alpha beta agonists

A

Extension of pharmacological effects 1: Tachy (B1) 2: Arrhythmia (B1) 3: Hypertensive crisis (a1) 4: Dry mouth, mild depression, sedation (a2) 5: Closed angle glaucoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name the a1 selective agonists

A

Phenylephrine**Methoxamine Midodrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

a1 selective agonist MOA

A

vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

a1 selective agonist uses

A

1: Reduce Bleeding 2: Hypotensive crisis 3: Nasal decongestion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

a2 selective agonists

A

MethyldopaClonidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Methyldopa MOA

A

prodrug (can be used in hypertension during pregnancy) acts ONLY on the CNS to increase sympathetic outflow and lower blood pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Clondine MOA

A

works on both the CNS (lower sympathetic outflow) and PNS (lower NE release)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Uses of a2 selective agonists

A

Hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Methyldopa side effects

A

Positive direct coombs & Hemolytic anemia lupus erythematosus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

B1 selective agonists

A

DobutamineDopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Dobutamine uses

A

Failed cardiac pump function - Severe Congestive heart failure - Cardiogenic shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Dobutamine MOA

A

increase cardiac output and contractility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Dopamine low dose

A

activation of D1 on kidneys resulting in increases diuresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Domamine intermediate dose

A

Activation of B1 in the heart to increase contractile force

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Dopamine high dose

A

acts on A1 receptors to increase peripheral resistance resulting in increase in HR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Dopamine uses

A

1: Septic Shock 2: Severe Congestive heart failure 3: Cardiogenic shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Nonselective Beta receptor agonist

A

Isoproterenol

24
Q

Isoproterenol uses

A

AV block (speed up conductance) Bradycardia Strokes-Adams attack (loss of cardiac output)

25
Q

Dopamine 1 agonist

A

Fenoldopam

26
Q

Fenoldopam uses

A

Hypertensive crisis (especially in those in renal failure)

27
Q

Fenoldopam MOA

A

bind DA1 receptors on coronary and renal artery to cause vessel relaxation

28
Q

Fenoldopam side effects

A

reflex tachycardia (due to stimulation of baroreflex)

29
Q

Fenoldopam contraindication

A

Glaucoma (open or closed angle) - increases intraoccular pressure

30
Q

Mixed alpha beta antagonists

A

Labetalol Carvediol

31
Q

Latetalol uses

A

1: Hypertension 2: Hypertensive crisis3: Ischemic heart disease

32
Q

Labetalol MOA

A

Competitive and reversibel binding to a1, B1, and B2 higher potency for BETA receptors

33
Q

Carvedilol MOA

A

Competive and reversible binding to a1, B1, and B2 higher potency for BETA receptors

34
Q

Carvediol uses

A

Hypertension Ischemic heart disease Chronic heart failure (preferred drug)(other: antioxidant, antiproliferative, NO production)

35
Q

Mixed alpha beta antagonist Adverse effects

A

Bradycardia Precipitation of acute heart failureBronchospasmCold extremities Raynauds diseaseCNS- mental depression, insomnia, fatigue

36
Q

Metabolic effects of mixed alpha beta antagonists

A

decreased blood glucose plasma levels altered plasma lipid levels (worsened profile)

37
Q

Contraindications of Beta receptor antagonists

A

Asthma (nonselective should be avoilded) AV block (can worsen condition)

38
Q

Nonselective alpha antagonists

A

Phenoxybenzamine Phentolamine

39
Q

Phenoxybenzamine uses

A

Pheochromocytoma

40
Q

Phenoxybenzamine MOA

A

competitive IRREVERSIBLE vasodialation Cardiac stimulation

41
Q

Phenoxybenzamine AE

A

reflex tachycardia

42
Q

Phenoxybenxamine Drug- drug interactions

A

High doses can block seratonin, histamine, and AcH

43
Q

Phentolamine uses

A

1: reversal of anesthesia 2: Hypertensive crisis associated with MOA inhibitor

44
Q

Phentolamine MOA

A

competitive REVERSIBLE, dose dependent Vasodilation Cardiac stimulation

45
Q

Alpha 1 selective antagonist

A

Prazosin

46
Q

Prazosin pharmacological effects

A

reduce LDL and TG and increase HDL suppress release of NE Dilate arteries and veins (decrease BP)

47
Q

Prazosin clinical uses

A

Pheochromocytoma Chronic hypertension with benighn prostatic hyperplasia (BPH) Urinary retention in men with BPHChronic hypertension (not commonly used)

48
Q

Prazosin adverse effects

A

First dose syncope (30-90 minutes after first dose) hypotension, dizziness, fainting, reflex tachycardia Nasal stuffiness, impotence, polyuria, water retention

49
Q

nonselective beta antagonist

A

Propranolol

50
Q

Propranolol uses

A

Infantile hemangioma hypertension ischemic heart disease Arrhythmia (Supraventricular and ventricular) Chronic heart failure

51
Q

Beta antagonist MOA (selective and non-selective)

A

decrease cardiac output (target SA and AV nodes to slow rate and O2 requirements of the heart)

52
Q

Beta antagonist AE (selective and non-selective)

A

Bradycardia

53
Q

Beta antagonist discontinuation (selective and non-selective)

A

requires tapering

54
Q

Beta antagonist drug-drug interaction (selective and non-selective)

A

insulin

55
Q

Beta antagonist contraindication (selective and non-selective)

A

Asthma and AV block

CardioRenal I (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions