cardio Flashcards
ECG territories + coronary artery supply
II, III, AvF: inferior, R coronary artery
V1-V4: anterior, LAD
I, V5-V6, AvL: lateral, L circumflex
aortic stenosis causes
- mostly calcification from increasing age
- congenital bicuspid aortic valve (20%)
other:
rheumatic fever
infective endocarditis
CKD (hyperphosphataemia)
aortic stenosis signs on exam
ejection systolic murmur radiation to carotids loudest at R upper sternal edge at end expiration soft S2 narrow pulse pressure heaving apex beat
indications for aortic valve replacement
symptomatic dilated LV BP drop on exercise LVEF < 50% valvular gradient > 40mmHg
aortic stenosis treatment options
conservative (RF optimisation, serial echo)
open aortic valve replacement
TAVI (transcatheter aortic valve implantation)
balloon aortic valvuloplasty
systolic murmur differentials
- aortic / pulmonary stenosis
- mitral / tricuspid regurgitation
- VSD
- HOCM
5, mitral valve prolapse
heart failure CXR findings
A: alveolar oedema (bat wings) B: kerley B lines C: cardiomegaly D: dilated upper lobe vessels E: pleural effusion
L heart failure signs
gallop rhythm (presence of S3) displaced apex beat (LV dilatation) pleural effusion bibasal creps (end-inspiratory) ± wheeze L sided murmurs (aortic / mitral)
R heart failure signs
raised JVP tender hepatomegaly (pulsatile w tricuspid regurg) peripheral pitting oedema ascites facial engorgement R sided murmurs (tricuspid / pulmonary)
immediate management acute cardiac failure
- ABCDE
- sit pt upright
- 15L high flow oxygen 60-100%
- diuretics: furosemide (also venodilates initially)
- GTN → venodilation → ↓preload
- diamorphine → venodilation
pharmacological Tx chronic cardiac failure
symptomatic: furosemide
prognostic:
1. ACE inhibitor + β-blocker (LVEF < 55%)
2. + ARB / spironolactone (LVEF < 35%)
3. entresto (delay 36hrs after stopping ACEi/ARB)
4. digoxin
cardiac resynchronisation therapy
beta blocker contraindications
severe heart failure
asthma / COPD
bradycardia
heart failure contraindicated drugs
• Pro-anti-arrhythmics w potentially negative inotropic effects e.g. flecainide
• CCBs e.g. verapamil, diltiazem (only amlodipine is advisable)
• Tricyclic antidepressants
• Lithium
• NSAIDs and COX-2 inhibitors
• Corticosteroids
• Drugs prolonging QT interval and potentially precipitating ventricular arrhythmias e.g.
erythromycin, terfenadine
• β-blockers contraindicated in severe heart failure
cardiac failure complications
- Pleural effusion
- Acute renal failure/chronic renal insufficiency
- Anaemia
- Sudden cardiac death
- Cardiogenic shock
- Pulmonary HTN
what is cor pulmonale
R heart failure caused by chronic pulmonary HTN
pulmonary hypertension signs on examination
raised JVP (prominent “a” wave)
L parasternal heave (R ventricular hypertrophy)
loud pulmonary component of S2
causes tricuspid regurgitation
- R ventricular pressure overload (pulmonary HTN, L sided heart failure)
- Pacemaker
- Infective endocarditis
- Rheumatic heart disease
- Connective tissue disease e.g. Marfan’s
- Ebstein’s anomaly (malpositioned tricuspid valve)
signs tricuspid regurg
pansystolic murmur
loudest at left lower sternal edge on inspiration
irregular pulse (atrial flutter / fibrillation)
large “v” waves of JVP
pulsatile hepatomegaly
complications tricuspid regurg
atrial arrhythmias: flutter / fibrillation
liver disease
myocardial infarction
atrial fibrillation causes
infection thyrotoxicosis ischaemic heart disease rheumatic heart disease alcohol pulmonary embolism
atrial fibrillation ECG findings
irregularly irreguarly rhythm
loss of P waves
fibrillatory waves
atrial fibrillation management
rate control: beta-blockers / CCBs
rhythm control if onset < 48hrs: DC cardioversion / flecainide / amiodarone
anticoagulation: LMWH + IV heparin
if > 48hrs: anticoagulate for 3-4 wks with warfarin + heparin then DC / chemical cardioversion
atrial fibrillation Sx + signs
palpitations dizziness / syncope irregularly irregular rhythm hypotension tachycardia
scoring systems for AF complications (2)
CHADSVASc: risk of stroke → >2 = anticoagulate
HAS-BLED: risk of haemorrhage → >2 = do not anticoagulate
1st degree heart block ECG changes
prolonged PR interval (>5 small squares/0.2s)
Mobitz type 1 ECG changes
progressive prolongation of PR interval until dropped QRS
Mobitz type 2 ECG changes
constant PR interval, occasional dropped QRS
type 3 heart block ECG changes
complete dissociation between P waves + QRS complexes
management chronic stable angina
conservative: exercise, smoking cessation, improved diet
medical:
anti-anginals:
1. beta-blocker
2. CCBs
3. beta-blocker + CCB (but not verapamil - risk of complete heart block)
4. long-acting nitrate, nicorandil (K-channel activator), ranolazine, ivabradine
+ statin + aspirin
GTN spray: pt should call ambulance if no relief 5min after 2nd dose
surgical: PCI (angioplasty) / CABG
stanford classification
for aortic dissection
A: ascending aorta (requires surg)
B: descending aorta (after L subclavian) (non-operative management)
varicose veins RFs
obesity DVT pregnancy COCP prolonged standing
signs of venous insufficiency
varicose veins
lipodermatosclerosis
corona phlebetatica
venous ulcers
varicose vein management
cons: weight loss, reduce standing, raise legs, compression stockings
minimally invasive: endothermal ablation (radiofrequency / laser), USS-guided sclerotherapy
surgical: ligation + stripping (under GA)
mitral regurgitation causes
acute: papillary muscle rupture due to MI / endocarditis
chronic:
functional: heart failure → LV dilatation → separation of valve leaflets
congenital: connective tissue disease e.g. EDS, Marfan’s
acquired:
infective endocarditis
IHD
assoc w atrial fibrillation
venous ulcer presentation
painless wet ulcer irregular sloped edges haemosiderin deposition oedema gaiter region (around medial malleolus) lipodermatosclerosis
arterial ulcer presentation
painful dry ulcer
well-demarcated
between toes / lateral aspect of foot / ankle
reduced / absent pulses
hypertensive retinopathy grades
- silver-wiring (tortuous vessels with shiny thick walls)
- grade 1 + AV-nipping (narrowing of arteries crossing veins)
- grade 2 + flame haemorrhages + soft exudates
- grade 3 + papilloedema
signs on examination infective endocarditis
Osler's nodes: painful Janeway lesions: painless, thenar eminence splinter haemorrhages Roth spots (fundoscopy) new murmur
most common causative organisms infective endocarditis
strep viridans (subacute)
staph aureus → IVDU (acute, RH valves, no chronic signs)
staph epidermidis → prosthetic valves
diagnostic criteria for infective endocarditis
Duke criteria
major: persistently +ve cultures w typical organisms
+ve echo
new regurgitation
mitral regurgitation signs
pansystolic murmur loudest over apex on expiration radiates to axilla soft S1 chronic → LV dilatation → displaced apex beat
mitral regurgitation management
cons: monitor w serial echo
medical:
for functional MR: ACEi, beta-blockers, diuretics
treat AF if present (rate, rhythm, anticoagulation)
surgical: annuloplasty / valve replacement
indications for valve replacement in mitral regurg
acute severe MR
symptomatic
LV dysfunction: LVEF < 50% / LV dilatation
complications: new onset AF / pulmonary HTN
mod / severe MR already undergoing CABG
definition critical limb ischaemia
> 2 wks of:
- pain at rest
- tissue loss: arterials ulcers, gangrene
- ankle pressure < 40mmHg
signs chronic peripheral vascular disease
reduced pulses dry shiny cracked hairless skin brittle nails auscultation → bruit Buerger's angle < 20
management chronic peripheral vascular disease
cons: exercise, smoking cessation, improve diet
med: treat CV RFs (HTN, dyslipidaemia, diabetes)
surg: angioplasty, endarterectomy, bypass
complications acute limb ischaemia
rhabdomyolysis → AKI
ischaemia → lactic acidosis, hyperkalaemia (→ cardiac arrest)