Cardio Flashcards
IA class antiarrhytmics? What channels block? 3 drugs
Na channel blockers
Quinidine, Procainamide, Disopyramide
Adverse effects of IA antiarrhemics
Cinchonism (tinnitus) quanidine
SLE-like syndrome (procainamide)
HF (disopyramide)
Thrombocytopenia
Forsakes de pointes (⬆️QT)
Phase O in fast response fibers ?
Na channels open
Na enters cell - depolarization
Phase O in slow response fibers
No appreciable Na current
Depolarization depends on Ca channels
What do Ia antiarrhytmic drugs do to K?
Block - prolong repolarization
As well as Na block
Quinidine block what receptors? Channels?
Na
K a bit
M (muscarinic): ⬆️HR ⬆️AV conduction
May cause vasodilation alpha-block - reflex tachycardia
Drug interactions of quinidine?
⬆️toxicity of digoxin
Lupus causing drugs?
Hydralazine
Isoniazid
Procainamide
HIP
Ib antiarrhythmia drugs?
What channels block?
Ap duration?
Weak Na block
Lidocaine
Mexiletine
⬇️Ap duration
Ib antiarrhetmyc drugs use when ?
Ap duration?
Diastolic duration?
HR?
Use only in hospital
Post-MI (best!), open heart surgery
Only for VA
Lidocaine - IV
Mexiletine - oral
Non-prophylactic
⬇️Ap
⬆️Diastole
⬇️HR
Side effects of Ib antiarrhetmics?
CNS toxicity (seizures, depression or stimulation) Carfiovascular depression
Ic antiarrhetmics? Mechanism? Ap? ERP? Contraindications?
Flecainide
Propafenone
(Fries, please)
STRONG Na channels block (especially His-Purkinje)
No or little effect on Ap duration
Flecainide - bad reputation!
⬆️mortality in post-MI and in VT use
Good for atrial arrithmias
Proarrhytmic (promotes arrhythmia) in post MI, VA
Contraindicated in ischemic, structural ❤️ diseases
Good for SVT (including AF)
How Procainamide metabolized?
Metabolized via N-acetyltransferase to N-acetyl Procainamide (NAPA) -prolongs AP duration
II class of antiarrhetmyc? 6 drugs Mechanism?
B-blockers
Metoprolol Propranolol Esmolol Atenolol. -lol 😂 Timolol Carvedilol
B-receptors activation - ⬆️ cAMP
B-blockers prevent activation - ⬇️cAMP, ⬇️Ca current
⬇️abnormal pacemakers by ⬇️slope of 4 phase
⬆️PR
⬇️AV (!) SV activity
Use of b-blockers?
SVT
Prophylaxis post MI
V and control of A fibrillation, A flutter
Because b receptors are all over the ❤️
Adverse effects of B-bl?
Metoprolol?
Propranolol?
Impotence ⬆️COPD, Astma HF Bradycardia AV block Sedation Metoprolol - dyslipidemia Propranolol - exacerbate vasospasm in vasospastic angina
B-by overdose? WhT to do?
Saline ( NaCl with water - изотонических раствор)
Atropine
Glucagon
III class of antiarrhetmyc? Mechanism? 4 drugs?
K channel blockers
⬆️Ap duration
⬆️ERP
⬆️QT
Slowing 3 phase - repolarization
AIDS:
Amiodarone
Ibutilide
Dofetilide
Sotalol
Clinical use of III class antiarrhetmyc
AF, AFlutter, VT (amiodarone, sotalol)
Life threatening ventricular arrhythmias
Amiodarone the smartest - mimic I, II, III, IV classes - blocks Ma, K, Ca, B- adrenoreceptors
⬆️APD ⬆️ERP in all cardiac tissues
Side effects of III antiarrhetmyc?
Pulmonary fibrosis (amyodarone) Smurf skin (iodine contain) - blue skin Photo toxicity Hepatic necrosis Thyroid disfunction Torsada (sotalole) - excessive b-blockade (Sotalol - nonselectove b-bl)
What check while using amiodarone?
PFT, LFT, TFT
Which classes of antiarrhetmyc don’t use in long QT syndrome?
1A
III
POTASSIUM CHANNEL BLOCKERS
Tricyclic antidepressants
Antipsychotic (thioridazine)
How to treat Torsades?
Discontinue drug that prolong QT
Correct hypokalemia
Correct hypomagnesemia
Give magnesium or defibrillate
Treatment of A Fibrilation
Ventricular rate control: b-bl, CCB, digoxin
Anticoagulants
Pulmonary fibrosis what 3 drugs can cause ?
Amiodarone
Bleomycin
Busolfen
Which drug instead of amiodarone use to avoid blue skin?
Dronedarone
Thioridazine?
Group?
When avoid?
Antipsychotic
Long QT
IV class antiarrhetmyc? Mechanism? 2 drugs?
Ca-Chanel blockers
Verapamil
Diltiazem
Block slow cardiac Ca Channels
⬇️conduction velocity
⬆️ERP
⬆️PR interval
Prolonged repolarization
⬇️ 4, 0
Inhibit Ca influx in AV nose
Use of IV antiarrhetmyc?
SVT
Rate control in AF
PREVENT nodal arrhythmias
Side effects of IV antiarrhetmyc?
Constipation (verapamil) AV block Dizziness Flushing Hypotension HF Edema
Drug interaction IV antiarrhetmyc
Verapamil displace digoxin
AV block with b-blockers, digoxin
Other antiarrhetmycs?
4
Adenosine
Magnesium
Ivabradine
Digoxin
Adenosine mechanism of action?
Duration of action?
When to use?
⬆️K out of cell
Hyperpolarizing the cell
Decrease AV node conduction
Duration - short, 15sec
Use in SVT
What’s activated of adenosine receptors cause? Where are they?
Cause Gi-coupled ⬇️ in cAMP
⬇️ SA AV activity
Side effects of adenosine?
Flushing, sedation, dyspnea
Drugs interaction?
Antagonized by…?
By methylxanthines ( theophylline, caffeine) Effects of adenosine blunted ⬇️
Adenosine is drug of choose …?
PSVT
Magnesium use?
Torsades
Digoxin toxicity
Ivabradine mechanism?
IVabradine prolongs slow depolarization (IV)
By selective inhibitions of funny sodium channels
Use of Ivabradine?
Chronic stable angina in those who can’t take b-bl
HF with reduced EF (HFrEF)
Adverse effects of ivabradine
Visual brightness (luminous phenomena)
Hypertension
Bradycardia
What drugs control HR?
B-bl, Ca cb
What to use in SVT?
How describe SVT?
II, IV, adenosine, digoxin
> 150
GRS narrows
P deformation
Drugs for VT?
Describe VT?
I, III
VT >120
Wide QRS >140ms
patients feel skipping beats
Ventricles contracts more often than Atrias
Saved By Pharm Class
I - Sodium
II - b-bl
III - potassium
IV - Calcium
If patient had ⬆️ ventricular response to stress, activity what to use?
Need for long usage
⬇️sympathetic
B-bl - propranolol
Drugs for essential HT
Thiazides diuretics
ACEI
ARB (angiotensin II receptors blockers)
Dihydropiridine
Ca cb
HT with HF treatment?
Diuretics ACEI ARB B-bl Aldosterone antagonists (spironolactone, epelerenone, canrenone)
HT with DM
ACEI ARB Ca cb Thiazides B-bl
HT with Asthma
ARB
Ca cb
Thiazides
Cardioselective b-bl
HT with CKD
ACEI
ARB
HT with dyslipidemia
A-blockers
Ca cb
ACEI
ARB
HT in post MI
B-bl
Useful in preventing second MI
What anti HT ⬆️ lipids?
Thiazides
B-bl
HT in pregnancy
Hydralazine - preeclampsia (new HT)
Labetalole also good for both
Methyldopa - drug of choice
Nifedipine
He Likes My Neonate
B blockers contraindications
Asthma AV block Bronchitis Emphysema Diabetic CARDIOGENIC SHOCK
Amiodarone?
Amlodipon?
Amlodipin - -dipines; CCBs
Amiodarone - K cb
CCBs mechanism of ⬇️BP
Block voltage-dependent L-type of Ca channels of ❤️ and smooth muscles = ⬇️ intracellular Ca => ⬇️CO(verapamil, diltiaz), ⬇️TPR (all) = ⬇️ muscle contractility
Use of CCBs?
Dihydropyridines (no nimodipine): HT, angina, Raynaud Phenomenon
Nimidopine: subarachnoid hemorrhage
Nicardipin, clividipine: HT urgency or emergency
Verapamil/ diltiazem: HT, angina AF, AFlutter
Arrhythmias: verapamil, diltiazem
Adverse effects of CCBs
Reflex tachycardia
Gingival hyperplasia
Constipation (ver)
Hyperprolactinemia (verapamil )
Pulmonary HT treatment
3 drugs
Bosentan - endoteline receptor blockers- vasodilation
Prostacyclin (PG2): Epoprostenol
Sildenafil: inhibit V PDE, ⬆️cGMP, pulmonary artery relaxation
Pregnancy HT drugs?
HLMN
Hydralazine
Labetalol
Methyldopa
Nifedipine
Slidenafil?
V type PDE inhibition
⬆️cGMP
Pulmonary artery HT
Tamsulosin
Only in BPH , not useful in HTN
Drug for:
HT + BPH
BPH
Prazozin
Tamsulozine
Arteriolar specific anti hypertensive drugs?
Hydralazine
K blockers
Ca blockers
Ventilations dilators anti hypertension drugs?
Nitrates
Orthostatic hypotension
From ventilations dilation - mainly from a1 blockage or ⬇️sympathetic tone
A1 - nonselective, but very powerful vein effect
Cyanide poisoning: 2 drugs
Hydroxocobalamin + sodium thiosulfate
Hypertensive emergency 5
Labetalol Clevidipine Fenoldopam Nicardipine Nitroprusside
cGMP
cAMP
What drugs to use?
⬆️cGMP - smooth muscle relaxation by nitrates, nitroprusside, hydralazine
⬇️cAMP - heart ❤️ ⬇️activity of AV SA nodes
Hypertensive emergency Ca drugs
Nicardipine, clevidipine
Hypertensive emergency drugs
Nicardipine
Clevidipine
Labetalol
Fenoldopam
Nitroprusside
Cyanid toxicity can be caused by what drug?
Nitroprusside
RanolaIazine
Mechanism
Use. Adverse
Inhibit late onward of Na => ⬇️diastolic was tension and O2 consumption
Does not change HR, BP
Angina refractory to other drugs
Conztipation, dizziness, nausea
Sacubitril
Neprilysin inhibitor
Prevents degranulation of natriuretic peptide, angiotensin II, substance P => ⬆️vasodilation, ⬇️ exstracellular fluid volume
Use with Valsartan (ARB) for HFrEF
Cough dizziness hypertension and Hyperkalemia
Contraindicated with ACEI inhibitors do you do angioedema
Blurry yellow vision
Digoxin
Digoxin tissue binding sites and ⬇️its clearance
Verapamil
Amiodarone
Quinidine
Antidote for digoxin toxicity
Slowly normalize K
Cardiac pacer
Anti-digoxin Fab fragments
Mg
Decstrocardia in what pathology
Kartagener syndrome - culinary dyskinesia
Defect in Left-right dynein - dextrocardia
Drug induced long QT
AntiArrhytmic (Ia, III) AntiBiotic (macrolids) AntiCychotic (haloperidol) AntiDepressant (TCA) AntiEmetics (ondansetron)
Congenital long QT interval pathologies (2)
Romano-Ward syndrome - AD, no deafness
Jervell and Lange- Nielsen syndrome - AR, sensorineural deafness
Brugada syndrome
AD Asian male Pseudo R bundle branch block, ⬆️ST in V1-V3 Risk of VT VA and SCD Prevent SCD with ICD
Wolff-Parkinson White s
Ventricular preexcitation syndrome Fast accessory conduction pathway from A to V , bypass the rate-slowing AV node V begin to depolarize early Widened QRS ⬇️PR Delta wave
May cause SVT
AF
No discrete P between irregular QRS
Irregular H beat
Risk: HTN, CAD, holiday ❤️ syndrome
Can cause thromboembolism, stroke
Anticoagulants, rhythm and Hr control, or cardioversion
A flutter
Saw tooth
R1=R2=R3…
Treat like AF
Catheter ablation
VF
Erratic rhythm with no identifying waves.
Can be fatal
Need IMMEDIATE CPR and defibrillate
I degree AV block
PR > 200 msec
No treatment
Second degree AV block
PR1
Third degree AV block
A and V beat independently
P=P
GRS=GRS
PG=/ PG
A rate > V rate
Pacemaker
Lyme disease
Lime disease
What’s with ❤️
Can cause third degree AV block
B type natriuretic peptide
Atrial natriuretic
From Ventricular myocytes in response to ⬆️tension
ANP - from atrial myocytes in response to ⬆️BV and Atrial P
Act via cGMP
vasodilation, ⬇️Na reabsorbtion
B type - linger half life
BNP - bliss test for HF
Nesiritid - recombinant form to treat HF
Cushing reflex
In ⬆️ intracranial P: triad: bradycardia
⬆️BP
respiratory depression
These all are physiological nerves system response to ⬆️intracranial pressure
Tetralogy of Fallot mnemonic
Pulmonary stenosis R ventricular hypertrophy Overriding aorda VSD e
Lithium explosire of pregnant - ❤️?
Ebstein anomaly
Tricuspid valve down in RV
“Atrializing” ventricle
Eisenmenger syndrome
Ebstein anomaly
Uncorrected L toR becomes R to L
Displacement of TV
Turner syndrome what with ❤️
Coarctation of aorta
Bicuspid aortic valve
Brachial femoral delay
Different pulse on upper and lower extremities
In coarctation
Marfan syndrome ❤️?
MVP
Thor’s is aortic aneurysms
Dissection
Aortic regurgitation
Infant of diabetic mother ❤️?
Transposition of great vessels
VSD
Williams syndrome ❤️
Supravalvular aortic stenosis
22q11 syndrome ❤️
DiGeorge
Truncus arteriosus
Fallot
2 hypertension what diseases
Fibromuscular dysplasia (string of beads renal artery) 1 hyper aldosteronism Atherosclerotic renal artery stenosis
Xanthelasmas composed of what ?
Lipid-laden histiocytes
Mönckeberg sclerosis
Medial calcific sclerosis Affect medial size arteries Vascular stiffening without obstruction Pipestime appearance on Xray Intima not involved Does not effect Q
Dilated cardiomyopathy inheriting
WhT Gene?
TTN Gene, encoding the Sarcomeric protein titin
Doxorubicin what with ❤️
Dilated cardiomyopathy
What infections cause dilated cardiomyopathy
Coxsackie B virus
Chagas’ disease
What systemic conditions cause dilated cardiomyopathy
Hemochromatosis
Sarcoidosis
Thyrotoxicosis
Wet beriberi
Takotsubo cardiomyopathy
Broken ❤️syndrome
Stress cardiomyopathy
Friedreich ataxia?
❤️?
Difficulty walking. Loss of sensation in arms, legs Impaired speech Starts 5-15 years ❤️ - hypertrophic cardiomyopathy
Löffler endocarditis
Associate with hyper eosinophilic syndrome
Hydrology- eosinophilic infiltrates in myocardium
Restrictive / infiltrative cardiomyopathy what cause?
Puppy LEASH
Postradiation fibrosis Loffler endocarditis Endocardial fibroelastosis Amyloidosis Sarcoidosis Hemochromatosis
Back triad
Cardiac tamponade
Hypertension
distended neck veins
distant heart sound
Pulsus paradoxus
⬇️ in amplitude of systolic blood pressure by > 10 During inspiration
Pea COAT
Constrictive pericarditis
Obstructive pulmonary disease (Croup, Asthma, COPD, OSA, cardiac Tamponade)
Symptoms of bacterial endocarditis
FROM JANE with ❤️
Fever
Roth spots (eye - white on retina surrounded by hemorrhage)
Osler nodes (ouchy raised lesions on the fingers or toe pads)
Janeway lesions (small painless Erythematos lesions on palm or sole)
Anemia
Nail-bed hemorrhage
Emboli
Is culture is negative while bacterial endocarditis what culture is most likely to be
Coxiella burnetii
Bartonella
S bovis
Colon cancer
On prosthetic walls bacterial endocarditis what culture is most likely to be
S epidermidis
Native valves bacterial endocarditis maybe do you to which organisms
HÁČEK HAEMOPHILUS Aggregatibacter (actinobaccilus) Cardiobacterium Eikenella Kingella
Major criteria of rheumatic fever
J❤️NES Joint - migratory polyarthritis ❤️carditis Nodules in skin subcutaneous Erythema marginatum (evanescent rash with ring margin) Sydenham chorea
Aschoff bodies
Granuloma with giant cells in romantic fever
Anitschow cells
Enlarged macrophages with ovoid wavy road like nucleus
Blood test in rheumatic fever
⬆️ASO antistreptol
⬆️anti-DNase B titers
Appearance of aorta in 3 syphilis
Tree bark - calcification and vasa vasorum disrupt
Can result in aneurysm of ascending A, aortic arch, A insufficiency
Treatment for acute pericarditis
NSAIDs
Colchicine
Glucocorticoid
Dialysis - uremia
Tuberous sclerosis
May cause no cancerous tumors in brain kidneys heart liver eyes lung skin
Rhabdomyomas
In children
Benign
Hamartomatous growths
Myxomas
Adults
IL-6 production symptoms (⬆️t, weight loss)
Tumor plop early diastole sound
Gelatinous material, myxoma cells immersed in glycosaminoglycans
Kussmaul sign
⬆️ in JVP in inspiration instead of ⬇️
May be seen with constrictive pericarditis, restrictive cardiomyopathy, right heart failure, massive pulmonary embolism, right atrium or ventricular tumors
Osler Weber Rendu syndrome
Hereditary hemorrhagic telangiectasia
AD
Twlangiectasias on skin, mucus M, recurrent epistaxis, skin discoloration, arteriovebous malformations, GI bleeding, hematuria
Large vessel vasculitis
Giant (temporal) arteritis
Takayasu arteritis
Medium vessel vasculitis
Buerger d (thromboangiitis obliterans) Kawasaki (mucocutaneus lymph nodes syndrome) Polyarteritis nodosa
Kawasaki
Conjunctivitis Rash Erythema Adenopathy Mucous membranes - strawberry tongue, dry lips
Kawasaki treatment
IV immunoglobulin
Aspirin
What can cause polyarteritis nodosa
Hepatitis type B
Polyarthritis nodosa treatment
Corticosteroids
Cyclophosphamide
For the arthritis nodosum what’s wrong with Renal
Renal micro aneurysm - string of pearls
Small vessels vasculitis
Becker syndrome
Cutaneous small vessels vasculitis
Eosinophilic geanulomatosis with polyangiitis (churg-strauss)
Granulomatosis with Polyangiitis (Wegenera)
Immunoglobulin a vasculitis
Microscopic polyangiitis
Mixed cryoglobulinemia