cardio Flashcards
Types of MI
Type 1- Infarction due to coronary atherothrombosis
Type 2- Infarction due to supply-demand mismatch that is not the result of acute atherothrombosis.
Type 3- Infarction causing sudden death without the opportunity for biomarker or ECG confirmation.
Type 4a- Infarction related to a percutaneous coronary intervention.
Type 4b- Infarction related to the thrombosis of coronary stent.
Type 5- Infarction due to CABG.
Acute renal failure after cardiac catheterization
Think of contrast nephropathy and renal atheroemboli
Cholesterol emboli:
the presence of other signs of embolization such as blue toes, livedo reticularis, Hollenhorst plaque in the retina and abdominal pain.
transient eosinophilia and hypocomplementemia
persistent renal failure after seven days.
Contrast nephropathy:
risk greatest in moderate to severe renal insufficiency and diabetes.
plasma creatinine concentration returns to baseline within seven days
to prevent this, use iso-osmolar agents in patients with CKD.
Features of complete heart block
- syncope
- heart failure
- regular bradycardia (30-50 bpm)
- wide pulse pressure
- JVP: cannon waves in neck
- variable intensity of S1
jvp
‘a’ wave = atrial contraction ( a for atrial)
- large if atrial pressure e.g. tricuspid stenosis, pulmonary stenosis, pulmonary hypertension
- absent if in atrial fibrillation
Cannon ‘a’ waves
- caused by atrial contractions against a closed tricuspid valve
- are seen in complete heart block, ventricular tachycardia/ectopics, nodal rhythm, single chamber ventricular pacing
‘c’ wave (c for closure)
- closure of tricuspid valve
- not normally visible
‘v’ wave (v for volume filling)
- due to passive filling of blood into the atrium against a closed tricuspid valve
- giant v waves in tricuspid regurgitation
‘x’ descent = fall in atrial pressure during ventricular systole
‘y’ descent = opening of tricuspid valve
mitral stenosis
Examination findings in MS: – reduced arterial pulse volume. – prominent “a” wave in JVP.Absent in AF. – prominent “v” wave secondary to TR. – right ventricular heave – palpable S2. – loud S1. – late diastolic murmur in mild MS, early diastolic murmur in severe MS.
Specific signs of severe MS:
– mitral facies (pinkish purple patches on cheeks)
– Prominent V wave in the jugular venous pressure
– right ventricular lift
– early opening snap following S2.
– loud pulmonary component of the second heart sound
– early diastolic murmur
(murmur diminished in Inspiration, augments with Expiration)
Other murmurs or sound when pulmonary hypertension is present:
– pulmonary ejection sound
– holosystolic murmur of TR heard best along right sternal border which increases with Inspiration
– Graham Steel murmur of Pulmonary Regurgitation best heard at the base.
Surgery is indicated in patient with moderate to severe MS in the following settings
Among patients who are symptomatic(NYHA class III-IV) if:
1) Percutaneous mitral balloon valvotomy is not available.
2) PMBV is contraindicated because of moderate to severe MR or of left atrial thrombus that persists despite anticoagulation.
3) Mitral valve morphology is not favourable for PMBV in patients with acceptable operative risk.
Symptomatic patients who also have moderate to severe MR.
Contraindications to PMBV
1) Mitral valve area >1.5cm2
2) Left atrial thrombus
3) Moderate to severe MR
4) Severe or bicommissural calcification
5) Absence of commisural fusion
6) Severe concomitant aortic valve disease,or severe combined tricuspid stenosis and regurgitation.
7) Concomitant CAD requiring bypass surgery.
If any of the following is present, proceed with surgery preferably mitral valve repair.
murmurs
Systolic Murmur:
Early systolic- MR, TR, VSD
Midsystolic ejection- Aortic stenosis, Aortic sclerosis.
Holo/Pansystolic – MR, TR, VSD
Late systolic- Mitral valve prolapse, Tricuspid valve prolapse
Diastolic murmur:
Early diastolic – AR, PR
Mid-diastolic- MS, TS, Atrial myxoma
Late diastolic- MS, TS, Atrial myxoma, Complete heart block.
Practical Tip:
rIght sided murmur louder on Inspiration
lEft sided murmur louder on Expiration
ICD placement IN HOCM
indicated if any ONE of the major risk factors are present:
1) Left ventricular wall thickness >30 mm
2) Family history of premature sudden cardiac death
3) Previous cardiac arrest/ventricular tachycardia
4) Previous episodes of documented non-sustained VT (>3 beats, rate >120 bpm)
5) Unexplained syncope
Drugs to avoid in CHF
- anti-arrhythmic agents (apart from beta-blockers and amiodarone)
- non-dihydropyridine calcium-channel blockers (verapamil, diltiazem)
- tricyclic antidepressants
- non-steroidal anti-infl ammatory drugs and COX-2 inhibitors
- clozapine
- metformin and thiazolidinediones(pioglitazone, rosiglitazone)
- corticosteroids (glucocorticoids and mineralocorticoids)
- tumour necrosis factor antagonist biologicals.
HASBLED score
Hypertension Abnormal renal and liver function Stroke Bleeding Labile INR Elderly Drugs or alcohol
1 pt each
≥3 indicates “high risk”
CHF drugs not shown to improve survival
No improvement in survival/mortality
1) Diuretics
2) Digoxin
3) Amlodipine
4) Felodipine
NYHA
Class I (Asymptomatic): No limitations in normal physical activity
Class II (Mild): Slight limitation of physical activity. Ordinary physical activity results in fatigue, palpitation, dyspnoea or angina pectoris
Class III (Moderate): Marked limitation of physical activity. Less than ordinary activity results in symptoms
Class IV (Severe): Unable to carry our any physical activity without discomfort. Symptoms present at rest
HOCM mx
Useful:
- beta blockers-ameliorate angina and syncope
- amiodarone-reduce frequency of supra ventricular
- non-dihydropyridine ca blocker-reduce the stiffness of the left ventricle, reduce the elevated diastolic pressures, increase exercise tolerance, and, in some instances, reduce the severity of outflow tract pressure gradients.
- disopyramide- reduce LV contractility
Not useful:
Digitalis, diuretics, nitrates, dihydropyridine calcium blockers, vasodilators,and beta-adrenergic agonists are best avoided, particularly in patients with known LV outflow tract pressure gradients.
Alcohol ingestion may produce sufficient vasodilatation to exacerbate an outflow pressure gradient.
dissection of the ascending aorta
1) Acute myocardial ischaemia or MI due to coronary occlusion.RCA most commonly involved.
2) Diastolic decrescendo murmur,hypotension and heart failure due to Acute aortic insufficiency
3) Murmur best heard along RIGHT sternal border.
4) Cardiac tamponade and sudden death
5) Hemothorax
6) A considerable variation >20mmmHg in systolic BP between the arms.
7) Neurological deficit including stroke or decreased LOC.
8) Horner’s syndrome
9) Vocal cord paralysis and hoarseness.
Classification of aortic dissection based on the Daily system:
1) Type A- dissection that involves the ascending aorta.
2) Type B- all other dissections.
AVOID
Hydralazine should be avoided as they increase shear stress and provide less accurate and reversible control of blood pressure.
For BP control
-iv labetalol - if Bp >100 –> sodium nitroprusside
acceptable normal variants in a young athelete
1) Bradycardia
2) Wenkebach
3) Junctional rhythm
4) First degree heart block
5) RBBB