CARDIO Flashcards
RFs for CAD
gender (begins to equalize with advanced age) HTN DM age cholesterol smoking family history obesity
Gold standard for Dx of CAD
Cardiac catheterization Others: EKG, echo, stress tests, CT angio
“Angiographically significant” finding of cardiac cath
Diameter is reduced by > 50%, corresponding to a reduction in cross-sectional area > 75%
Artery of concern in the heart
Left anterior descending artery (LAD) “Widow maker”
Who goes to the OR in CAD?
Severe angina (CCS class III/IV) Unstable angina Triple vessel dz Left main dz Failed medical therapy Thrombosis, post PTCA or in-stent restenosis Emergently from cath lab (coronary dissection)
CABAG post-MI
Postinfarction ventricular septal defect (VSD) Papillary muscle rupture with acute mitral insufficiency LV free wall rupture
Postinfarction ventricular septal defect
4-5 days after MI Present with CHF and pulmonary edema and new systolic murmur Need intra-aortic balloon pump (IABP) placed and undergo emergent repair
Papillary muscle rupture with acute mitral insufficiency
4-5 days post MI Heart failure, new murmur Prompt valve repair or replacement
LV free wall rupture
Cardiogenic shock, often acute tamponade Emergent surgery = 50% successful
CABG
Aim to restore flow from aorta to the coronaries distal to obstruction Does NOT rid patient of disease or disease process Uses vascular “conduits” With or without assistance of bypass (“on pump” vs “off pump”)
Benefits of off-pump CABG
Less risk of encephalopathy, sternal infection, blood transfusion, and renal failure
Advantages of cardiopulmonary bypass
Quiet, bloodless field Better distal anastamoses Still the standard
Disadvantages of cardiopulmonary bypass
Increased time in surgery pt must be heparinized then reversed platelet dysfunction (HIT) complications can include hypoperfusion fluid retention CVA Ischemia
Gold standard for conduit
Left internal mammary artery to LAD (aka left internal thoracic artery) Others: saphenous vein (for lateral and posterior walls), radial artery
Mechanical Valves
Tilting disk and older ball-in-cage designs -Highly durable, require permanent anticoagulation therapy (INR at 2.5 to 3.5 times normal) -Preferable in patients with long life expectancy
Tissue for valve replacement
Xenograft (porcine or bovine), homograft (cadaver), or autograft (pulmonic valve) -Less thrombogenic, do not require anticoagulation -More prone to structural failure due to calcification -15-20 years
Aortic Stenosis (AS)
Stenosis from thickening, calcification, fusion of aortic leaflets causing LV outflow obstruction Pressure overload of LV leads to LVH Younger patients with congenital bicuspid valves Older– history of rheumatic fever Sx: angina, syncope, CHF Dx: Echo, +/- cardiac cath PE systolic murmur in 2nd R IC space Surgery indicated if symptomatic or based on cross sectional area of valve and gradient across valve
Aortic Valve Incompetence
Incompetence of aortic valve, backflow causes LV dilation, LVH Causes: bacterial endocarditis, hx of rheumatic fever, aortic root dilation, bicuspid valve predisposes Dx: echo, cath PE: “Blowing” decrescendo diastolic murmur L sternal border Surgery if symptomatic