Cardio 3 Flashcards
What is the definition of heart failure?
clinical syndrome with symptoms/signs caused by a structural or functional cardiac abnormality AND confirmed by elevated natriuretic peptide levels or evidence of pulmonary or systemic congestion
What is the equation for cardiac output?
CO = HR x SV
What is cardiac output?
the volume of blood in liters pumped form ventricles per minute
What is the cardiac output goal?
maintenance of adequate tissue perfusion
The MAP equation is __
MAP = __ diastole + __ systole
MAP = SV x HR x SVR
2/3 diastole
1/3 systole
Heart rate is affected by:
Autonomic innervation
Hormone regulation
Fitness level
Age
Stroke volume is affected by:
Preload
Afterload
Contractility
Heart size (gender)
Fitness level
Age
Preload:
“stretch”
Volume of blood inside ventricles during diastole
Quantify: left ventricle end-diastolic volume (LVEDV or EDV
Afterload:
“squeeze”
esistance ventricles must overcome to force blood into systemic circulation
Quantify: systemic vascular resistance (SVR), pulmonary vascular resistance (PVR), end-systolic volume (ESV)
Contractility:
“strength”
Contraction of the myocardium through the actin-myosin cross bridge cycle
Quantify: ejection fraction (EF)
EF = (EDV - ESV) / EDV : stroke volume
Preload is affected by:
Heart rate
Ventricle compliance
Atrial contraction
Venous/aortic pressure
Total blood volume
Afterload is affected by:
Aortic pressure
Systemic vascular resistance
Ventricle wall thickness
Ventricle radius
Contractility is affected by:
Sympathetic nervous system
Heart rate
Ca2+
Rhythm
What is an average cardiac output for an adult male?
CO = HR x SV
70 bpm x (70ml/1000)
= 4.9 L/min
(4-8 L/min)
LVEDP is a surrogate for __
EDV
Decrease in after load or an increase in contractility leads to a HIGHER/LOWER SV
Higher SV
Increase in after load or decrease in contractility leads to a HIGHER/LOWER SV
Lower SV
CVP is the __ pressure
right atrial pressure
LVEDV is the __ pressure
Pulmonary-Capillary Wedge pressure
What can impact intracardiac pressures?
Heart failure (hypervolemia)
Pulmonary arterial hypertension
Pleural effusion
Cardiac tamponade
Hypovolemia
Shock
HFrEF is due to __ failure
systolic (heart contraction)
HFpEF is due to __ fialure
diastolic (heart relaxation)
HFrEF is due to:
Loss of __
__ ventricles
__ dysfunction
Loss of intrinsic contractility
Overstretched: weak and thin ventricles
Pumping (systolic) dysfunction
HFpEF is due to:
Failure of __
__ ventricles
Reduced __
__ dysfunction
Failure of ventricles to relax properly
Thick and stiff ventricles
Reduced ventricle volume in diastole
Filling (diastolic) dysfunction