Cardiac Surgery Flashcards
Besides activating FXI, what else can FXII activate
complement system, neutrophils, leads to inflammation
synthetic surfaces activate which pathway? Surgical wounds?
intrinsic, extrinsic
Activation of neutrophils and monocytes can lead to_______
SIRS, systemic inflammatory response syndrome
why do we do pretty much all the precautions in CPB?
to avoid microemboli
What do we use for protection? What is the mech?
K+ rich cardioplegia. It makes the membrane potential more positive so the inactivation gates stay closed, preventing repolarization
what mediates apoptosis of myocyte during reperfusion
caspase-3. Executioner caspase
what artery is used for grafts? vein?
left internal mammary artery (LIMA)
saphenous vein
Which (IMA or SVG) is more prone to atherosclerosis? Why?
SVG. Veins sustain endothelial damage during harvesting. the IEL of arteries helps prevent SMC migration
Which of the coronary arteries has the best and worst runoff flow?
LAD-best
RCA-worst
What is the order of importance of coronary arteries in triple CABG?
LAD>LCX>RCA
What is the order of quality of graft vessels?
LIMA>RIMA>SVG>Radial>gastroepiploic
Are you more likely to get calcification on bio valve or mechanical?
bio. More likely to get clotting on mechanical
