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Pharm Exam 2 > Cardiac Pharm part 2 > Flashcards

Cardiac Pharm part 2 Flashcards

1
Q

Examples of antithrombotic drugs

A

aspirin
clopidogrel
tirofiban
vorapaxar

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2
Q

MOA of Aspirin

A

inhibits COX which reduces thromboxane (TXA) production

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3
Q

MOA of clopidogrel

A

an ADP receptor antagonist on platelets

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4
Q

MOA of Tirofiban

A

an antagonist on GPIIb/IIIa platelet receptor which blocks platelet binding to fibrinogen in an area of platelet plug formation

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5
Q

Examples of Anticoagulants

A

Heparin
Warfarin
Dabigatran

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6
Q

MOA of Heparin

A

is an antithrombin

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7
Q

MOA of Warfarin

A

is a vitamin K antagonist. Substitutes for vitamin K in the cascade that makes clotting factors and makes them non-functional

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8
Q

MOA of Dabigatran

A

direct thrombin inhibitor

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9
Q

Labs to monitor while on heparin

A

PTT

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10
Q

labs to monitor while on warfarin

A

INR and PTT

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11
Q

MOA of Lovastatin

A

HMG CoA reductase inhibitor which suppresses lipoprotein synthesis

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12
Q

MOA of gemfibrozil

A

inhibits hepatic triglyceride synthesis thus suppressing lipoprotein synthesis (VLDLs and sometimes LDLs) and also increases the production of HDLs that activates reverse cholesterol transport from peripheral vascular beds

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13
Q

MOA of Niacin

A

triglyceride lipase inhibitor in adipose tissue that reduces hepatic triglyceride synthesis and lipoprotein synthesis

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14
Q

MOA of cholestyramine

A

ion exchange resin that binds to bile salts and results in their elimination through the feces; hepatic production of cholesterol is diverted from production of lipoproteins to bile salts

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15
Q

MOA of ezetimibe

A

inhibitor of cholesterol transport protein; blocks absorption of dietary cholesterol and cholesterol that enters the enterohepatic circulation

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16
Q

What is entresto used for

A

it is a medication used to prevent heart failure. It is a combination of sacubitril (neprilysin inhibitor) and valsartan (ARB)

17
Q

What is neprilysin?

A

An enzyme that metabolizes natriuretic peptides like ANP

18
Q

MOA of entresto

A

Sacubitril inhibits neprilysin (an ANP metabolizer), leading to more ANP in the body. ANP reduces salt and water retention associated with HF. Valsartan is an ARB which also helps decrease bp and fluid retention

Pharm Exam 2 (3 decks)

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