Cardiac Pathophysiology Flashcards
Dr. Mike Wacker (UMKC)
What are causes of valvular abnormalites?
What is mitral stenosis, and what would happen to the pressures in the LA and LV?
What is mitral regurgitation? What would happen to the LA and LV pressures compared to normal?
Blood flows back into the LA during systole, causing the LA to expand
What is aortic stenosis? What happens to LA and LV pressure, and pressure in the aorta compared to normal?
- Narrowing of the aortic valve, slow to open
- Increased afterload
- Cardiac hypertropy
- SV decreased
- LV pressure increases due to increased afterload
What are the three ways to do a transcatheter aortic valve replacement (TAVR)?
What does aortic regurgitation (insufficiency) do to LA, aortic, and LV pressure compared to normal?
- Blood flows back into LV from the aorta
- Increasing preload and stroke volume
- Chamber dilation
What are symptoms that a patient could have indicating valvular abnormalities?
When would you hear heart murmors for the different vavular abnormalites?
What are some causes of dialated cardiomyopathy and problems that it can lead to?
What are some causes of pathological hypertrophy and problems that it can lead to?
How is physiological hypertrophy different than pathological?
Possible causes of an MI? What problems does it lead to?
What are cardiomyocyte marker for an acute MI? At what levels is it indicitave of one?
What happens immediately after someone experiences an MI, and the following weeks after?
How does aspirin work and what does it do?
What do fibrate (Gemfibrozil) medications do and how do they work?
What do Statins (atorvastatin - Lipitor) do and how do they work?
What do PCSK9 inhibitors do and how do they work?
What is the difference between diastolic HF and systolic HF?
What changes happen in cardiomyocytes after heart failure?
What causes arrythmias during heart failure?
How is there compensation during mild HF?
What are symptoms of chronic (decompensated) HF?
What are key symptoms to lood for with patients that have HF?
What is circulatory shock?
What are the different types of circulatory shock?
What type of shock would these symptoms be indicative of? How would the body compensate?
What are common inotropic agents used for treatment of acute HF?
Would dobutamine increase myocardial O2 demand because it increases HR?
Yes and no. Dobutamine is a chronotropic agent but also a vasodilator, so by dilating vessels you would decrease afterload and the demand of the heart
What are some causes of septic shock?
What can septic shock lead to? What is an alternative treatment to vasopressors in septic shock?
What is the mechanism behind septic shock?
What is and what occurs during anaphylactic shock?
What is neurogenic shock, and causes of it?
Regardless of the type of shock, all lead to these symptoms?
Explain the positive feedback loop of the progression to shock starting from decreased tissue perfusion
What is ECMO and indications for use?
