Cardiac Function Flashcards
What 3 markers are used to help diagnose an MI?
CK , AST and LDH
How is CK used to diagnose MI and how fast does it rise and fall?
- used as general screen but it too is non-specific.
- Increase seen in 6 hours. Back to normal in 3 days (males–15-160,females 15-130)
How is CKMB used to diagnose MI and how fast does it rise and fall?
Is more cardiac specific. Rise 4-6 hours, Peak 12-24 hrs and normal 2-3 days post onset. (98% of MI abn / 3% non-MI abn )
What values for the CK/CKMB index reflect muscle and heart?
<3 muscle ; >6 MI
What is the LD flip and what is it indicative of?
LD1 > LD2 peak at 48 hrs. Back to normal w/in 10 days
indicative of MI
What is the role of Troponin in the body?
Binds calcium and regulates muscle contraction
In the event of a MI how fast does troponin rise and fall?
Rise 4-6 hrs, peaks 12-18 hrs and normal 4-10 days – catches old MI’s that don’t come to ED
Normal = 0.1 ng/ml
.What types of troponin are used in the lab?
TnI and TnT
What is myoglobin’s role in the body?
O2 binding heme protein found in cardiac and skeletal muscle ( thus – non specific )
How fast do myoglobin values rise and fall after a MI
Is sensitive – will rise 1-3 hrs, peak seen in all MI patients at 6-9 hrs, normal 18-24 hrs
What are normal myoglobin values in males and females?
Males – 30-90 ng/dL ; females <50 ng/dL
What is CRP and what is its function?
acute phase protein produced by liver is response to infection, injury and inflammation. Non-specific marker for inflammation
What is hsCRP and what is its function?
more cardiac specific. Small changes can be seen earlier
Higher hsCRP associated with higher risk of future cardiac related mobidity and mortality
What is homocysteine?
HCYST is an amino acid found in the blood
What is hyperhomocysteinemia related to?
CHD , stroke and peripheral vascular disease
