Cardiac drugs Flashcards
Spironolactone mechanism
Aldosterone antagonist acts in cortical collecting ducts
Bisoprolol mechanism
Competitively blocks B1 receptors
Propranolol mechanism
Blocks B1 + B2 receptors
Indapamide mechanism
Inhibits sodium reabsorption of DCT by blocking thiazide sensitive NaCl symporter
Warfarin mechanism
Inhibits epoxide reductase preventing Vit K activation - prevents carboxylation of 2, 7, 9, 10
Clopidogrel mechanism
P2Y12 ADP antagonist - inhibits platelet activation
Furosemide mechanism
Loop diuretic inhibits NaKCl co-transporter in thick ascending limb
Bumetanide mechanism
Loop diuretic inhibits NaKCl cotransporter in thick ascending limb
Amiloride mechanism
Potassium sparing diuretic blocks epithelial sodium channel in DCT
Metolazone mechanism
Thiazide like diuretic
Ticagrelor mechanism
ADP receptor antagonist PYY12
LMWH mechanism
Potentiates antithrombin III, inhibits factor Xa
Heparin mechanism
Potentiates antithrombin III, inhibits factor IXa, Xa, XIa, XIIa
Eplerenone mechanism
Aldosterone antagonist, potassium sparing diuretic
Amiodarone mechanism
Blocks potassium channels
Aspirin mechanism
Blocks cyclooxygenase 1 & 2, responsible for thromboxane A2 - platelet aggregation
Prasugrel mechanism
ADP antagonist, P2Y12 antagonist
Dabigatran mechanism
Direct thrombin inhibitor
Atropine mechanism
Muscarinic acetylcholine antagonist
Adenosine mechanism
Blocks the AV node
Digoxin mechanism
Inhibits Na-K-ATPase pump
Tirofiban mechanism
GpIIb/IIIa inhibitor
Abciximab mechanism
GpIIb/IIIa inhibitor
Bivalirudin mechanism
Reversible direct thrombin inhibitor
