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Autoantibodies Flashcards

1
Q

TPO

A

Hashimoto’s thyroiditis

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2
Q

TSH receptor

A

Grave’s disease

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3
Q

IgG anti-platelet

A

ITP

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4
Q

21-hydroxylase

A

Addison’s

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5
Q

Ro

A

SLE antibody associated with congenital heart block, Sjogren’s

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6
Q

GM1

A

AIDP

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7
Q

MuSK

A

Myasthenia gravis

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8
Q

NMDA

A

Encephalitis

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9
Q

Intrinsic factor

A

Pernicious anaemia

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10
Q

Gastric parietal cell

A

Pernicious anaemia

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11
Q

Jo-1

A

Polymyositis

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12
Q

CCP

A

Rheumatoid arthritis

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13
Q

Rheumatoid factor

A

Rheumatoid arthritis

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14
Q

Most specific Ab for rheumatoid arthritis

A

CCP

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15
Q

Cardiolipin

A

Antiphospholipid syndrome

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16
Q

Beta 2 glycoprotein

A

Antiphospholipid syndrome

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17
Q

Lupus anticoagulant

A

Antiphospholipid syndrome

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18
Q

SMA smooth muscle antibody

A

Autoimmune hepatitis type 1

19
Q

LKM1 liver kidney microsomal

A

Autoimmune hepatitis type 2

20
Q

QG1b

A

Miller Fisher syndrome

21
Q

Ganglioside

A

Guillian Barre syndrome

22
Q

Centromere

A

Limited cutaneous systemic sclerosis

23
Q

Scl-70

A

Diffuse cutaneous systemic sclerosis (bad prognostic factor)

24
Q

La

A

Sjogren’s

25
Presynaptic voltage gated calcium channels
Lambert Eaton Myasthenic Syndrome
26
GAD
Paraneoplastic stiff person syndrome (breast, colorectal, small cell lung cancer)
27
Hu
Paraneoplastic sensory neuropathy + cerebellar syndrome + encephalomyelitis (SCLC, neuroblastomas)
28
Purkinje cell
Paraneoplastic peripheral neuropathy (breast cancer)
29
Yo
Cerebellar syndrome (ovarian, breast cancer)
30
Ri
Opsoclonus myoclonus (breast, SCLC)
31
DsDNA
SLE
32
Sm (Smith)
SLE
33
SLE most sensitive
ANA
34
SLE most specific
DsDNA & Smith
35
Histone
Drug induced lupus
36
GBM glomerular basement membrane
Goodpasture's
37
Desmoglein 3
Pemphigus vulgaris
38
Hemidesmosome
Pemphigoid
39
cANCA
GPA, MPA
40
pANCA - MPO
eGPA
41
U1-RNP
Mixed connective tissue disease
42
Phospholipase A2
Primary membranous glomerulonephritis
43
Mi-2
Dermatomyositis

autoantibodies (3 decks)

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