Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHARMACY > Cardiac Anticoagulant > Flashcards

Cardiac Anticoagulant Flashcards

1
Q

Preferred agent for reversing Xa inhibitors (apixaban rivaroxaban(

A

andexanet alfa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Agent to reverse dabigatran (direct thrombin (factor IIa) inhibitor)

A

idarucizumab (praxbind)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cockroft formula

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Ideal Body weight

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Adjusted body weight

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CHA2DS2-VASc

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

hasbled score

(3 or higher is considered an increased risk of bleeding)

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Scoring for CHADS2-VASc

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Reversing enoxaparin with protamine

A

1 mg of exoxaparin is equal to 100 antiXa units

1 mg of protamine will reverse 1 mg of enoxaparin

1 mg of protamine will reverse 100 units of heparin

if over 8 hours give 1/2 of the protamine dose (enoxaparin)

if over 2 hours give 1/2 of the protamine dose (heparin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When do you transition from warfarin to apixaban?

A

wait until INR falls to less than 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

When should edoxaban not be used?

A

When CrCl is greater than 95 ml/minute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the 1st line treatment options for VTE

A
  1. rivaroxaban
  2. apixaban
  3. warfarin plus LMWH bridge
  4. edoxaban with LMWH predosing
  5. dabigatran with LMWH predosing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CHEST guidelines on VTE treatment

A

DOACS are recommended over vitamin K antagonist such as warfarin, for VTE treatment without an associated cancer diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

If pt on warfarin and being started on amiodarone, the dose should be reduced by how much percent?

A

30 to 50 %

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Triggers for vasoocclusive crisis in patients with sickle cell disease

A

infections, dehydration, stress, changes in weather

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When is AC therapy recommended for patients with AF?

A

CHA2DS2VASc

score oft two or more in men

score of three or more in women

except those with moderate to severe mitral stenosis or a mechanical heart valve

Warfarin- DOC in end-stage renal chronic kidney disease

Dabigatran, rivaroxaban, apixaban, edoxaban are all preferred over warfarin for cardioembolic stroke prevention in patients indicated for AC therapy

17
Q

Warfarin affects which vitamin K dependent clotting factors

A

2, 7, 9 and 10

18
Q

warfarin reversal

A

4 factor PCC (Kcentra) 5000 units

(50 units/kg) not to exceed 5,000 units

also vitamin K 10 mg IV

(subcut has erratic and unpredictable absoprtion

19
Q

apixaban and rivaroxaban reversal

A

Andexanet alfa

20
Q

what is needed for Vitamin B 12 be absorbed?

A

Intrinsic factor

21
Q

Approved VTE prophylaxis in knee replacement surgery

A

apixaban and rivaroxaban

22
Q

Approved VTE prophylaxis in hip replacement surgery

A

apixaban, rivaroxaban, dabigatran

23
Q

What interacts with iron?

A

fluroquinolones, levothyroxine and tetracyclines

24
Q

What can increase the absorption or bioavailability of the elememental iron?

A

Vitamin C

25
Q

Dosing for rivaroxaban for VTE

A

15 mg BID po BID for 21 days followed by 20 mg daily

26
Q

Common medications with causing thrombocytopenia

A

chemo agents

heparin

linezolid

LMWH

quinine

ranitidine

ticlopidine

valproic acid

vancomycin

27
Q

What class is apixaban?

A

Xa inhibitor (DOAC) BID dosing

28
Q

What class is dabigatran

A

Direct Thrombin inhibitor

29
Q

What class is prasugrel

A

P2Y12 antagonist (ADP inhibitor)

30
Q

Types of macrocytic anemia

A

folic acid (B9) and cyannocobalamin (vitamin B12 )

31
Q

what are fat soluble vitamins?

A

ADEK

32
Q

Which has greater degree of platetelet inihibition?

A

prasugrel and ticagrelor more than clopidogrel

33
Q

What are the DOACs

A

apixaban, edoxaban, rivaroxaban

34
Q

FDA approved to chelate iron

A

deferasirox (exjade)

deferiprone (Ferriprox)

deferoxamine (desferal

What is NOT

dexrazoxane (Zinecard)

35
Q

what is the half life of amiodarone?

A

60 days

36
Q

When to hold apixaban?

A

For low risk procedures: dermatologic or dental procedures (root canal, multiple tooth extraction): hold one day prior and restart the next day

For high risk procedures: hold 2 days prior then restart 2 to 3 days after the procedure

37
Q

what is the onset of action for 4 factor PCC

what about vitamin K or phytonadione

what about FFP?

A

10 minutes for 4 factor PCC

4 to 6 hours for IV and 18-24 hours for oral (vitamin K)

slower by 6.5 hours compared to 4PCC

38
Q

When does Rh incompatibility occur?

A

When Rh negative Mom is exposed to Rh positive fetus, leading to the mother’s development of Rh antiboides

39
Q

In immune mediated HIT what percentage reduction of platelets is usually seen?

A

30 to 50 percent

PHARMACY (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions