Cardiac Flashcards

1
Q

EKG with cor pulmonale

A

Right atrial hypertrophy - peaked p waves II, III, aVF

RVH - right axis deviation, partial or complete bundle branch block

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2
Q

Goals with AS

A
  1. Maintain sinus rhythm, esp avoiding tachycardia
  2. Adequate preload
  3. Maintain after load. CPP = aDP - LVEDP
  4. Maintain Contractility
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3
Q

AS gradient requiring surgery

A

50mmHg

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4
Q

CVP 22, PA 44/25, CI 1.5L/min, what is going on?

A

Tamponade

  • Beck’s Triad: hypotension, JVD, muffled heart sounds
  • pulsus paradoxus

Tx (fast, full, tight)

  • Elevated HR (CO is HR dependent)
  • Fluids
  • Ionotrope support (epi +/- ketamine)
  • Spontaneous vent
  • Alert surgeon –> back to OR
  • CVP dominant x descent, minimal y descent
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5
Q

Hemodynamic changes with aortic cross clamp

A

Proximal: inc after load, inc BP, CVP, PAOP, dec CO and EF

Distal: Dec RBF and mesenteric BF

inc MvO2, acidosis,

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6
Q

Hypotension on CPB

A

Low CO from hemodilution or Low SVR

Inc flow rate or give Neo

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7
Q

Steps coming off bypass

A
Normothermia
Midazolam to prevent awareness
Make sure monitors, machine, alarms are on
Correct lab abnormalities - anemia, electrolyte
Heart de-aired
Start ventilation
Check TEE to assess function
Have pacing on standby
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8
Q

Side effects of nitroprusside infusion

A

CN toxicity
Metabolic acidosis
Arrhythmia
Tachyphylaxis

Tx = 100%O2, hydroxycobalomin

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9
Q

Heparin for bypass

A

3-4 U/kg
ACT 300-400 (480)

Protamine 1mg/100U heparin - acid base reaction

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10
Q

Goals with HOCM in pregnancy

A

Continue beta blockers
Maintain preload
Maintain SVR
Maintain slow normal rate and SR

Avoid spinal (sympathectomy)
Epidural and GA ok
Pitocin - ok if given slow

Afib = cardioversion or esmolol

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11
Q

How does IABP work?

A

Sits in aorta, deflates during systole reducing afterload and inflates during diastole inc coronary perfusion

This dec myocardial work, inc O2 supply to myocardium

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12
Q

How would you evaluate an AICD preoperatively?

A

Baseline cardiovascular function, underlying rate and rhythm
Indication for AICD
Functioning properly, battery, any shocks
Contact manufacturer
Behavior when exposed to magnet

If within 6 inches, magnet/ manufacturer to deactivate defibrillator and place pads
Set to asynchronous DOO
Avoid cautery or use bipolar or short bursts

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13
Q

How to protect spinal cord perfusion during aortic cross clamp

A
Adequate BP
Hypothermia
CSF drain
Shunt across clamp
Avoid vasodilators that inc ICP and this spinal cord perfusion pressure
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14
Q

Cardiac considerations for Down syndrome

A

Any endocardial cushion defects
ASD, VSD, PDS, TOF
Uncorrected —> pulmonary HTN

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15
Q

Indications for endocarditis PPx

A
Dental, skin or resp procedure
Prosthetic material
Previous BE
Unrepaird CHD
Repaired CHD with 6 months
Residual defect
Transplant with valvulopathy
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16
Q

Would you delay the case to optimize blood pressure? How long?

A

I would look at BP trends, evidence of end-organ damage (LVH, renal, vascular disease).

Evaluate the patient for symptoms of end organ damage as well - headache, chest pain, EKG, pulmonary edema, SOB

If urgency of case did not allow optimization over several weeks, I would lower to 140/90

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17
Q

Centrifugal vs roller pump

A

Roller pump

  • partial compression of tubing by two roller heads
  • NOT sensitive to preload or afterload
  • can deliver pulsatilla flow
  • reliably delivers certain flow based on pump speed
  • more RBC trauma
  • potential for large air embolism

Centrifugal

  • rotational force responsible for forward flow
  • sensitive to preload and afterload
  • will not work if senses air
  • less trauma to RBCs
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18
Q

Alpha stat vs. pH stat, which one is preferable

A

Slightly better neurological outcomes with alpha-stat in adults
- hypothermia inc solubility of CO2 and dec arterial pH and partial pressure of CO2

pH stat adds CO2 to oxygenator to maintain PaCO2 of 40 and pH 7.4
- ischemia not emboli primary mechanism in peds = pH stat preferred in peds

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19
Q

Acute vs chronic mitral regurg

A

Acute = left atrial overload without compensatory ventricular dilation—> dec CO, pulm edema, RV failure

Elevated LVEDP and tachycardia increases risk of ischemia

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20
Q

Temp monitoring for bypass

A

Measure core and shell due to temp gradient that develops during cooling and rewarming

  • nasopharyngeal and toe or rectal
  • ensures adequate cerebral cooling and avoid large temp gradients (>10deg) that can lead to bubble formation in blood
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21
Q

Goals for mitral regurg

A

Fast full, forward
Maintain HR, preload + afterload reduction

Adequate anesthesia during laryngoscopy to avoid HTN, tach inc MR and myocardial O2 demand

Avoid over aggressive induction, hypotension, BRADYCARDIA –> worsening regurg and dec coronary perfusion

Either lead to ischemia—> AFIB

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22
Q

Low reservoir volume, what would you do?

A

Reduce pump flows
Add fluid
Look for heart manipulation, kinking, malposition of venous cannula

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23
Q

Why is de-airing important?

A

Lung re-inflation recruits alveoli, inc pulm blood flow displacing air into left heart where it can be removed with a vent

This dec end organ damage from embolization to cerebral and coronary arteries

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24
Q

Inc PA pressure and dec BP during bypass wean

A

LV failure

  • inc afterload (esp after MVR)
  • graft failure from clot, kink, air
  • poor CBF from hypotension, emboli, spasm, tachycardia
  • hypovolemia
  • acidosis
  • hypoxemia
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25
Q

Failure to wean from bypass causes and solutions

A

Poor pre-op EF and need for ionotropes
Aortic cross clamp time
Severe MR

Ensure adequate volume, temp
Correct acidosis, anemia, hypoxemia, labs
IABP - dec afterload, inc coronary perfusion

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26
Q

AICD code VVE-DDDRO

A

Shock - ventricular
Anti-tach pacing - ventricular
Electro gram detection

Pacing - dual
Sensing - dual
Triggered or inhibited response to sensing - dual
Rate responsiveness
Not capable of multi site pacing
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27
Q

What are the Debakey classifications

A

Type 1 - aortic dissection ascending aorta distal to abdominal aorta

Type 2 - ascending and do not extend past innominate

Type 3 - beyond left subclavian to abdominal

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28
Q

Would you place a lumbar drain for thoracic dissection repair?

A

CSF drainage could facilitate SC perfusion given inc in CSF pressure with cross clamp

Have risk benefit discussion with surgeon. Is there time to delay systemic heparinzation 60 minutes or up to 24 hours with traumatic placement?

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29
Q

Where would you places line for aortic dissection repair?

A

Consider upper and lower extremity lines to identify inadequate perfusion distal to cross clamp.

Upper extremity a-line in right to avoid interference from clamp

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30
Q

How does hypothermia affect coagulopathy?

A

Defects in platelet aggregation and adhesion

Below 33 enzyme activity is abnormal

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31
Q

EKG with hyperK

A
Peaked T-waves
Prolonged PR
Widened QRS
Loss of P-wave
—> VF
32
Q

How long to delay elective surgery following:
Balloon angioplasty
BMS
DES

A

2 weeks
4 weeks
consider at 3 months stent risk < surgery delay but ideally 6-12 months

33
Q

Mechanism of TXA

A

Binds plasminogen preventing prevents its interaction/activation with fibrin –> plasmin

34
Q

Prolonged R-time

A

Low clotting factors, heparin, LMWH

Give FFP

35
Q

Prolonged K time

A

Dec thrombin or fibrinogen

Give cryo

36
Q

Indications for further cardiac work-up with MVP

A

Significant MR, syncope, chest pain or CHF

37
Q

Hypotension and inc PA pressures following protamine cause

A

Histamine release or Type III protamine reactions

  • release thromboxane A2 –> inc PA pressures and right heart failure
  • prevention = diluting and giving slowly
  • avoid giving thought PAC (pHTN) or bypass circuit (clot)
38
Q

Recommendations regarding peri-operative beta blockade

A

Continue in those on BB

Consider for vascular and intermediate surgeries with risk factors - hx ischemic disease, CHF, CVA, DM, CRI

39
Q

DDX for pacing failure

A
MI
Lead dislogement
Lead failure
Inadequate amplitude
Hypercarbia
Acidosis
40
Q

DDX for post-CABG bleeding

A

1 = platelet dysfunction

Fibrinolysis
Hemodilution
Poor surgical hemostasis
Inadequate heparin reversal
hypothermia
DIC

Check ACT, PT/PTT, Fibrinogen, TEG

41
Q

What are some cardiac and non-cardiac causes of AFIB

A

Cardiac
- valvular, HTN, LVH, SSS

Non-cardiac
- idiopathic, PE, thyroid, etOH

42
Q

What are the risk factors for stroke with AFIB

A

CHADS2VASC

  • CHF
  • HTN
  • Age >65
  • DM
  • Stroke
  • Vasc disease
  • sex female
1 = consider
2 = likely benefit from anticoagulation
43
Q

How would you treat hypotension in a patient with a heart transplant?

A
  1. check for arrhythmia
  2. maintain preload
  3. direct vasoconstrictor (Neo)
  4. isoproterenol or epi gtt
  5. check for anaphylaxis, PE, other causes

Notes:
No vagal influences/response
- higher resting HR
- no reflex bradycardia

44
Q

Risk factors for stent thrombosis

A
#1 - cessation of DAPT
surgery - inc catecholamines, inc platelet agg, dec fibrinolysis
small lesion
multiple stents
overlapping stens
malpositioned or residual dissection
long stents
left main or ostial stents
low EF
DM, CRF, old age
45
Q

How is bridging therapy employed?

A

when bleeding risk on thienopyridine too high

  1. discontinue 5-7 days before surgery
  2. continue ASA
  3. start short acting platelet inhibitor (tirofiban) 2-3 days before surgery
  4. consider concomitant heparin gtt
  5. discontinue tirofiban 6 hours before surgery
46
Q

A-line waveform changes when moving further from the heart

A

SBP inc + DBP dec = widened pulse pressure
Dicrotic notch disappears
MAP minimally affected

47
Q

Ddx for narrow pulse pressure

A
Hypovolemia
AS
Tamponade
Systolic HF
Overdampening
48
Q

DDx for widened pulse pressure

A
Isolated systolic HTN (elderly pt)
AI
Thyrotoxicosis
Distributive shock
Underdampening
49
Q

CVP waveform with A-fib

A

Loss of A-wave

Prominent C-wave

50
Q

CVP waveform with AV dissociation

A

Cannon A-wave

51
Q

CVP waveform with TR

A

Broad tall C-V wave
No X-descent

resembles RV pressure tracing

52
Q

CVP waveform with RV ischemia

A

Inc CVP
Tall A & V
Steep X & Y descent

Resembles M or W pattern
Same as constrictive pericarditis

53
Q

CVP waveform with tamponade

A

Dominant X descent

Attenuated Y descent

54
Q

Normal PAP range

A

15-30/5-15mmHg

Diastolic pressures inc compared to RV pressures

55
Q

What is a normal SvO2?

A

70-75%

56
Q

Ddx for inc SvO2

A

Low O2 extraction

  • sepsis
  • cyanide
  • MethHb
  • CO
  • hypothermia

High CO

  • sepsis
  • burns
  • L-R shunt
  • AV fistula
  • excessive ionotrope
  • Hepatits, pancreatitis
57
Q

Ddx for dec SvO2

A

Dec Hb

  • anemia
  • hemolysis

Dec CO

  • MI
  • CHF
  • hypovolemia

Dec SaO2
Inc VO2 - shivering

58
Q

How does clopidogrel work?

A

ADP receptor inhibitor which inhibits platelet activation

59
Q

If the patient had 90% carotid occlusion on surgical side and 100% occlusion on opposite side, which side would you place the central line?

A

I would prefer to do it on the side of 100% occlusion because if I hit the carotid artery, there is no risk of further injury since the vessel is already blocked.

If i started it on the surgical side, I would run the risk of total occlusion of circulation to the brain

60
Q

What is meant by watershed areas?

A

areas of circulation that border between the 2 carotid arteries.

if patient had poor perfusion from non-clamped carotid artery, high likelihood of stroke in the watershed area

61
Q

Changes with EEG during carotid cross clamp, surgeon says he cannot release the clamp. How do you respond?

A

Ensure patient is not hypoxic, hypotensive, anemic
Ensure appropriate depth of anesthesia

I would ask to place a shunt or
inc BP to improve cerebral perfusion while watching for signs of myocardial ischemia

62
Q

Why not place a carotid shunt prophylactically in all patients undergoing CEA?

A

Not without risks

- serves as a conduit for small emboli –> stroke

63
Q

What are the benefits of off-pump CABG vs. on-pump?

A

OPCAB = avoidance of CPB machine

  • inflammatory response
  • neurologic injury
  • coagulopathies
  • platelet dysfunction
  • fibrinolysis
  • renal impairment
  • arrhythmias (afib)

On-pump

  • technically easier
  • hemodynamic changes managed by perfusionist more easily
64
Q

How might recent MVR contribute to LV failure coming off bypass?

A

Lose low resistance outflow to RA –> inc LV after load

65
Q

What is pulsus paradoxus?

A

Exaggeration of normal variation in SBP and pulse during inspiration.

More negative intrathoracic pressure –> inc VR –> inc RV volume and bulging of septum into LV

66
Q

Describe the hemodynamics of aortic outflow tract obstruction and issues that are complicated by neuraxial anesthesia

A

CPP = aorticDBP - LVEDP

In AS, LVEDP is elevated –> dec CPP
Thus to maintain it is critical to maintain aortic BP = MAP

Neuraxial –> vasodilation and dec MAP

67
Q

How would you respond to a request for neuraxial anesthesia in a patient with CHF and EF 20%?

A

I would not place a spinal because this results in sympathectomy –> venous pooling –> dec SV in a patient with already poor EF –> cardiac compromise

68
Q

After surgery, the patient complains of chest pain and you note new ST segment elevation on the bedside monitor. How will you proceed?

What if he develops hypotension, dyspnea and rales?

A

I would:

  1. call for help - apply defibrillator, activate STEMI team
  2. obtain 12-lead EKG to confirm and determine location of MI
  3. Treat any pain (MONA-B)
  4. Apply oxygen
  5. Nitrates (unless inferior MI or hypotensive)
  6. Beta blocker (unless hx asthma, hypotensive)
  7. Aspirin

Then consider PCI, heparin gtt (fibrinolytic checklist), ionotropes +/- diuretic with CHF

69
Q

How would you treat a protamine reaction?

A
Volume
O2
Epi
CaCl
Pacing
Go back on bypass
70
Q

What are some causes of long QT?

A

Suspect with syncope with activity

Drugs

  • TCAs
  • many antibiotics
  • metoclopramide
  • haldol

Genetic

Myocardial

  • MI
  • cardiomyopathy

Electrolytes
- Low K, Mag, Ca

71
Q

How would you manage new finding of prolonged QT with syncope?

A

Identify cause
Cardiology consultation
Avoid precipitants - meds, hypothermia, ischemia, low electrolytes
Avoid inc sympathetic tone

Beta blockers
ICD

72
Q

New onset PVC or bigeminy, what do you think? How would you manage?

A

I am concerned this represents structural or ischemic heart disease which would place this patient at risk for inc morbidity and mortality.

Rule out other causes

  • stimulants
  • acidosis, hypoxemia, hypo/er K+, hypoMag

Tx - Lidocaine, beta-blockers (propanolol, metop)

73
Q

Describe the ACC/AHA algorithm for patients undergoing non-cardiac surgery

A

Emergent –> go to OR

Non-Emergent
–> screen for active cardiac conditions and treat (MI w/in 7 days, unstable angina, decompensated CHF, significant arrhythmia or severe valvular disease)

Low risk surgery –> go to OR

Intermediate or high-risk

  • –> assess functional capacity
  • –> >4 METS –> go to OR

<4 METS or unknown

  • 1-2 risk factors –> proceed with HR control or consider noninvasive testing
  • 3+ risk factors –> consider testing if it will change management
74
Q

Aortic cross-clamp is applied and BP 200/100, PA 50/30, CI 1.3, how will you treat?

A

I would ensure patient is not hypoxic, check for ST changes and arrhythmia.

Give nicardipine to dec afterload
+/- ionotrope
Nitroglycerin if ST changes indicating MI

75
Q

What are the signs of digoxin toxicity?

A

AF/A-flutter + heart block (bigeminy common)

Tx = Digibind or atropine –> pacing –> epi infusion

76
Q

Ddx for poor r-wave progression

A
Previous anteroseptal MI
LVH
RVH
Incorrect lead placement
Normal variant