Carcinoma in situ

Question 1

What is carcinoma in situ?

Answer 1

malignancy contained within the basement membrane, they are pre-malignant conditions, usually found on imaging and rarely symptomatic

Question 2

What are the two main types of carcinoma in situ in the breast?

Answer 2

Ductal carcinoma in situ and lobular carcinoma in situ

Question 3

What is ductal carcinoma in situ?

Answer 3

most common type of non-invasive breast cancer, malignancy of the ductal tissue in the breast and contained within the basement membrane

Question 4

What investigations are done for ductal carcinoma in situ?

Answer 4

detected in screening and appears as microcalcifications on mammography, confirmed by biopsy

Question 5

What is the management for DCIS?

Answer 5

Complete wide excision and if widespread or multifocal may need complete mastectomy

Question 6

What is lobular carcinoma in situ?

Answer 6

malignancy of the secretory lobules of the breast that are confined within the basement membrane, rarer than DCIS

Question 7

When is LCIS usually diagnosed?

Answer 7

Before menopause

Question 8

What are the investigations for LCIS?

Answer 8

Incidental finding in biopsy of breast

Question 9

What is the management for LCIS?

Answer 9

Monitoring is low grade, bilateral prophylactic mastectomy can be preformed for BRCA 1 or 2