Carcinoma Flashcards
1
Q
Oncocytoma
A
benign
distal tubule
eosinophilic epithelial cells
2
Q
Renal cell carcinoma common spread?
A
renal vein - thrombosis
IVC/SVC/Heart
3
Q
Clear cell focality?
A
unifocal
4
Q
Papillary cell focality?
A
multifocal
5
Q
Gradation in clear cell
A
based on nuclear appearance
6
Q
Gradation in papillary cell
A
based on cellularity
7
Q
chromophobe renal cell
A
5% (3rd most common 3rd most aggressive - difficult to distinguish from oncocytoma - stain with iron)
8
Q
Clear cell genetics?
A
VHL 3p
9
Q
Papillary cell genetics?
A
Trisomy 7
Met Locus - protooncogene
10
Q
Urothelial carcinoma span?
A
renal pelvis to urethra
11
Q
Urothelial risk factors?
A
smoking
schistosomiasis (Africa more likely squamous bladder cancer)
12
Q
Urothelial markers?
A
FGFR mutation - better
TP53 mutation - worse
