CARCINOGENICITY Flashcards
1
Q
list the conditions/dz caused by Ochratoxin A (OTA)
A
- balkan endermic nephropathy
- urinary tract tumors(UTT)
2
Q
what is karyomegally
A
- end stage renal failure
- it means increase in size og nuclues of tissue cells
3
Q
cs of karyomegally
A
- urinary loss of proteins
- glucose,
- GGT
- serum:
- decreaed cholesterole,
- protein
- progressive tubulo-interstitial nephropathy
- tubular atrophy
- periglobular atrophy
- cortical cysts
4
Q
pathological marker in OTA toxicity
A
karyomegally in proximal tubular cells
5
Q
acute toxicity testing
A
- single dose of LD50
6
Q
90 days rodent assay determines……………..
A
NOAEL
7
Q
NOAEL PROVIDES THE BASIS FOR …………….
A
ADI
8
Q
A
9
Q
WHAT IS THE USE OF ADI
A
- PROVIDES THE BASIS FOR ACCEPTABLE RESIDURE LEVELS IN FOOD,
- MRL (VMP)= IN EDIBLE TISSUE OF ANIMALS (MILK,TISSUE)
- ML=MAXIMUM (PERMISSIBLE) LEVELS→CONTAMINANTS→ALL FOOD
10
Q
A
11
Q
A
