Cannabis

Question 1

what plant does cannabis from? what part of the plant?

Answer 1

cannabis Sativa, the leaf

Question 2

where is the highest concentration of psychoactive compounds found?

Answer 2

resin, flower of female plant

Question 3

which components affect the brain?

Answer 3

delta-9 THC

CBD, cannabidiol

Question 4

Dronabinol (Marinol), what does it treat

Answer 4

synthetic THC
anorexia
appetite in AIDS patients
anti-emetic for chemo paitents
capsule form

Question 5

nabilone, what does it treat

Answer 5

analog of THC
same conditions as dronabinol
chronic pain

Question 6

negative effects of THC

Answer 6

impairs cognition, memory

psychomotor retardation

Question 7

anxiolyetic/anxiogenic

Answer 7

reduces anxiety

increases anxiety

Question 8

analgesia

Answer 8

loss of sensation of pain, pain-relief

Question 9

MOA of THC and CBD, relationship

Answer 9

THC - agonist of the CB1, quiets other neurons
CBD - antagonist of CB1
but THC > CBD so effects occur

Question 10

other MOA of CBD

Answer 10

agonist 5HT1A
agonist for GPR55, unknown affect
orphan receptor^^

Question 11

endocannabinoids (eCBs), MOA

Answer 11

endogenous cannabinoids produced within the body, activates CB1/CB2

Question 12

what is CB1 receptor and where is it located?

Answer 12

GPCR, pre-synaptic terminal, reduces amount of other transmitters released

Question 13

where are eCBs made?

Answer 13

post-synaptic

Question 14

Why does THC have so many effects?

Answer 14

they cause a range of NTs to fire more or fire less, both inhibitory and excitatory

Question 15

two most common eCBs?

Answer 15

anandamide, first discovered

2-AG, most abundant

Question 16

explain the process of 2-AG, CB1, and glutamate?

Answer 16

too much glutamate
2-AG produced, binds to CB1
CB1 causes less glutamate to fire
less activation at the post synaptic

Question 17

what does glutamate do?

Answer 17

learning, memory, excitation

Question 18

why are eCBs important?

Answer 18

important modulator for neurons, dials down excessive activity

Question 19

where is CB1 located within the body?

Answer 19

abundant throughout the body, mostly the brain, most brain areas

Question 20

where is CB2 located

Answer 20

“peripheral” cannabinoid receptor, more throughout the body than the brain
- mostly on immune cells

Question 21

eCBs vs. THC

Answer 21

eCBs

• improve learning, memory
• appetite stimulant
• analgesic, descending pathway
• bone formation
• modulator for neuron firing
• short half life

THC

• long lasting acute effect
• appetite stimulant
• ant-emetic
• impairs learning, memory
• psychosis?