Cannabis Flashcards
what plant does cannabis from? what part of the plant?
cannabis Sativa, the leaf
where is the highest concentration of psychoactive compounds found?
resin, flower of female plant
which components affect the brain?
delta-9 THC
CBD, cannabidiol
Dronabinol (Marinol), what does it treat
synthetic THC anorexia appetite in AIDS patients anti-emetic for chemo paitents capsule form
nabilone, what does it treat
analog of THC
same conditions as dronabinol
chronic pain
negative effects of THC
impairs cognition, memory
psychomotor retardation
anxiolyetic/anxiogenic
reduces anxiety
increases anxiety
analgesia
loss of sensation of pain, pain-relief
MOA of THC and CBD, relationship
THC - agonist of the CB1, quiets other neurons
CBD - antagonist of CB1
but THC > CBD so effects occur
other MOA of CBD
agonist 5HT1A
agonist for GPR55, unknown affect
orphan receptor^^
endocannabinoids (eCBs), MOA
endogenous cannabinoids produced within the body, activates CB1/CB2
what is CB1 receptor and where is it located?
GPCR, pre-synaptic terminal, reduces amount of other transmitters released
where are eCBs made?
post-synaptic
Why does THC have so many effects?
they cause a range of NTs to fire more or fire less, both inhibitory and excitatory
two most common eCBs?
anandamide, first discovered
2-AG, most abundant
explain the process of 2-AG, CB1, and glutamate?
too much glutamate
2-AG produced, binds to CB1
CB1 causes less glutamate to fire
less activation at the post synaptic
what does glutamate do?
learning, memory, excitation
why are eCBs important?
important modulator for neurons, dials down excessive activity
where is CB1 located within the body?
abundant throughout the body, mostly the brain, most brain areas
where is CB2 located
“peripheral” cannabinoid receptor, more throughout the body than the brain
- mostly on immune cells
eCBs vs. THC
eCBs
- improve learning, memory
- appetite stimulant
- analgesic, descending pathway
- bone formation
- modulator for neuron firing
- short half life
THC
- long lasting acute effect
- appetite stimulant
- ant-emetic
- impairs learning, memory
- psychosis?
