Canine Anesthesia Flashcards

1
Q

Why do dogs (and cats) have a higher mortality rate during anesthesia compared to humans

A

Anesthesia causes cardiorespiratory depression which is the main cause of death, hence it’s important to monitor the patient during anesthesia to reduce the risk of death

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2
Q

Before putting a dog under anesthesia what is some things you would want to consider that could influence you anesthetic plans

A

Look at their history: what drugs are they on, do they have systemic disease, have a history of previous anesthetic complications, have a history of blood transfusions
What is their signalment: age, sex, breed
What is their temperament

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3
Q

What a some medications of concern for anesthetic procedure and the brief description of why it is concerning

A

Diuretics - can cause hypovolumeia and electrolyte changes
ACE inhibitors/ Ca channel block/ beta block - cause hypotension
Anti-epileptic agents - cause extra sedation and are hepatic enzyme inducer
Serotonin drugs - risk of serotonin syndrome (more of a problem when the ingest human prescription)
NSAIDS/Steroids

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4
Q

What should you do if a patient is coming in for an anesthetic procedure and are presenting with a cough, exercise intolerance, or syncope

A

*realize they are having signs of systemic disease that is affecting the cardiorespiratory system and are at a greater risk of anesthetic death
*postpone procedure if possible and try to stabilize the patient

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5
Q

Do dogs have naturally occurring antibodies against red blood cell antigens

A

No they need to have been exposed to the antigens and for days to go before they produced. Hence they normally do not have severe reactions to their first blood transfusion

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6
Q

What is the universal blood donor for dogs

A

It’s best to use DEA 1.1 Negative blood

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7
Q

What is a breed specific concern of Northern breeds (Huskies, Malamutes, Samoyed, Inuit)

A

They are resistant to sedative effects of opioids and acepromazine
Opioids can cause excitement during recovery
Best to give opioids with alpha-2 (dexmedetomidine)

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8
Q

What is a breed specific concern of Herding breeds (Australian shepherds, collies,)

A

Have MDR-1 gene mutation so they have higher level of drugs entering the brain so more susceptible to CNS depression from acepromazine and opioids
Avoid use of Ace and use low doses of opioids

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9
Q

What is a breed specific concern of brachycephalic breeds (bulldogs, pugs, and Boston terriers)

A

They can have BOAS (brachycephalic obstructive airway syndrome) in which they are at high risk of hypo ventilation/hypoxemia and aspiration pneumonia which puts them at high risk of death

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10
Q

What is the best anesthetic protocol for dogs with BOAS (premed, induction, maintenance, recovery)

A

-premed - Antiemetic (maropitant), + steroid (decrease airway swelling) +/- anticholinergics +/- opioids (methadone/butorphanol). Make sure to minimize stress and start monitoring right away
-induction - pre-oxygenate, rapid IV induction (propofol/alfaxalone). Intubate with smaller ET tube
-maintenance - with quickly reversible drugs and possible mechanical ventilation
-recovery - monitor SpO2, late extubation, adequate analgesia

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11
Q

What is a breed specific concern of sighthounds

A

Avoid thiobarbiturates due to prolonged recovery

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12
Q

What is a breed specific concern of greyhounds

A

Susceptible to anesthetic induced hyperkalemia and excessive post op bleeding
Monitor ECG, K levels, and give antifibrinolytic perioperative

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13
Q

What is a breed specific concern of boxers

A

Possible sensitivity to acepromazine and concern for collapse

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14
Q

What is a breed specific concern of small breeds (yorkies, Pomeranians, poodles, chihuahuas, etc)

A

They are at risk of tracheal collapse (will present with dyspnea, exercise intolerance, goose-honk cough, stridor)
Recommended to avoid excitement (sedation), avoid coughing (butorphanol for its antitissive effect), have longer ET tube to reach the carina

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15
Q

What are some premeditation drugs in dogs

A

-Anticholinergics (Atropine and glycopyrrolate) - useful in BOAS patients, dogs undergoing ophthalmic s/ GI endoscopy, don’t use with alpha-2, NOT A NORMALLY USED PREMED (treats low HR AND HYPOTENSION)
-Benzodiazepines - sedation for young, sick, old patients with minimal cardiovascular and respiratory effects
-Acepromazine- mild/moderate sedation (can cause hypotension and hypothermia)
-Dexmedetomidine - marked sedation at high doses (can cause hypertension, reflex bradycardia, decreased cardiac output)
-Opioids- analgesic (methadone,fentanyl, and butorphanol more common due to least likely to cause vomiting)

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16
Q

What are commonly used pre-med combo in healthy patients

A

Acepromazine and opioids

17
Q

What is a more helpful drug premed combo for aggressive dogs

A

Deemedetomidine and opioid combos
GIVE WITH sedatives (ketamine/ telazol/ alfaxolone so no unexpected arousal form alpha2)
There is also an OTM (oral transmucosal) option of dexmedetomidine

18
Q

What is a good drug combo in sick or geriatric patients to provide adequate sedation

A

Opioids +/- midazolam

19
Q

What are some non-anesthetic premeds you can give to dogs

A

Diphenhydramine- H1 antihistamine
Maropitant (Cyrenaica) - NK1 receptor antagonist to provide some adjunct analgesia

20
Q

What are some at home pre-meds for anxious and aggressive dogs

A

-Trazodone - serotonin antagonists and serotonin reuptake inhibitors (SARI) - anxiolytic and sedative
-Gabapentin - blocks release of excitatory NT - anticonvulsant, anxiolytic, sedative
-Acepromazine- added for additional sedation

21
Q

What are some induction agents in dogs and what should your choice of induction be based on

A

Base choice on cardiovascular status
-Propofol, Alfaxalone, Etomidate
-Ketamine and Benzodiazepines (longer onset, duration and higher therapeutic index)

22
Q

What are some maintenance anesthetics in dogs

A

Inhalant- isoflurane, sevoflurane
TIVA - propofol,alflaxalone
Adjunct CRIs - opioids, lidocaine, ketamine, dexmedetomidine

23
Q

What is the intra-op fluid rate in dogs

A

5 ml/kg/hr

24
Q

What are some intraoperative complication

A
  • cardiovascular- hypotension, bradycardia
  • respiratory- hypercapnia, lower than ideal PaO2
    -hypothermia
    -Regurgitation- passive process involving relation of cardia that allows GI contents up -> can cause esophageal damage or aspiration pneumonia
25
Q

What is the MAP/SAP when a dog is hypotensive

A

MAP <60mmHg
SAP <90mmHg

26
Q

What is the heart rate of a bradycardic dog

A

HR < 60-70bpm

27
Q

What is the ETCO2 and PaCO2 of a hypoventelated dog

A

ETCO2 - >45mmHg
PaCO2 - >45mmHg

28
Q

What should the PaO2 value be of a dog who is inspiring >95% O2

A

PaO2 - 500mmHg

29
Q

What are some things you can do to prevent regurgitation in dogs

A

-fasting
-give drugs
*proton pump inhibitors, H2 antihistamines- increase gastric pH
*prokinetic (metoclopramide) - decrease chance of regurg

30
Q

When is the most common time for anesthetic related death occurs in dogs

A

Recovery period
Extubation upon swallowing reflex
Hence you should monitor patient to ensure they have normal respiratory function, can maintain sternal recumbent, hold head up, temp >98.5F

31
Q

What are drugs you can use during recovery

A

Opioids for acute pain during recovery
Acepromazine or dexmedetomidine for anxiety or uncomfort

32
Q

What are the three new FDA approved drugs on the market for dogs

A

-Dexmedetomidine oral gel (Sileo) - treatment for canine noise aversion that can go OTM route for sedation/anxiolysis
-Medtomidine-Vatinoxan combo (Zenalpha) - alpha2 agonist / peripheral alpha2 antagonist IM injection for sedative-analgesic effect with decreased cardiovascular effect (but hypotension possible if followed by inhalant anesthetic)
-Bedinvetmab (Librela) - anti-NGF monoclonal antibody therapy for pain associated with OA