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Cancer Stuff Flashcards

1
Q

Proto-oncogene: abl

A

CML

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2
Q

Proto-oncogene: c-myc

A

Burkitt’s lymphoma

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3
Q

Proto-oncogene: bcl-2

A

Follicular and undifferentiated lyphomas

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4
Q

Proto-oncogene: erb-B2

A

Breast, ovarian and gastric carcinomas

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5
Q

Proto-oncogene: ras

A

Colon Carcinoma

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6
Q

Proto-oncogene: L-myc

A

Lung Cancer

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7
Q

Proto-oncogene: N-myc

A

Neuroblastoma

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8
Q

Proto-oncogene: ret

A

MEN types II and III

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9
Q

Proto-oncogene: c-kit

A

Gastrointestinal stromal tumor (GIST)`

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10
Q

Tumor Suppressor Gene: Rb

A

Retinoblastoma, osteosarcoma

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11
Q

Tumor Suppressor Gene: BRCA 1 and BRCA 2

A

Breast and ovarian cancers

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12
Q

Tumor Suppressor Gene:p53

A

Most human cancers, Li-Fraumeni syndrome

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13
Q

Tumor Suppressor Gene: p16

A

Melanoma

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14
Q

Tumor Suppressor Gene: APC

A

Colorectal Cancer (associated with FAP)

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15
Q

Tumor Suppressor Gene:WT1

A

Wilm’s tumor

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16
Q

Tumor Suppressor Gene: NF1

A

Neurofibromatosis type 1

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17
Q

Tumor Suppressor Gene: NF2

A

Neurofibromatosis type 2

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18
Q

Tumor Suppressor Gene: DPC

A

Pancreatic Cancer

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19
Q

Tumor Suppressor Gene: DCC

A

Colon Cancer

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20
Q

CA associated with: Down Syndrome

A

ALL, AML

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21
Q

CA associated with: Xeroderma pigmentosum, albinism

A

melanoma, basal Cell CA, squamous cell CA of the skin

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22
Q

CA associated with: Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

A

Gastric AdenoCA

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23
Q

CA associated with: Tuberous Sclerosis

A

Astrocytoma, angiomyolipoma, cardiac rhabdomyoma

24
Q

CA associated with: Actinic keratosis

A

Squamous cell CA of the skin

25
Q

CA associated with: Barrett esophagus

A

Esophageal AdenoCA

26
Q

CA associated with: Plummer-Vinson Syndrome

A

Squamous Cell CA of the esophagus

27
Q

CA associated with: Cirrhosis

A

hepatocellular CA

28
Q

CA associated with: Ulcerative colitis

A

colonic adenoCA

29
Q

CA associated with: paget’s disease of the bone

A

secondary osteosarcoma and fibrosarcoma

30
Q

CA associated with: Immunodeficiency states

A

malignant lymphoma

31
Q

CA associated with: AIDS

A

aggressive malignant lymphomas (non Hodgkins)

32
Q

CA associated with: autoimmune diseases

33
Q

CA associated with: acanthosis nigricans

A

visceral malignancy

34
Q

CA associated with: dysplastic nevus

A

malignant melanoma

35
Q

CA associated with: radiation exposure

A

sarcoma, papillary thyroid CA

36
Q

CA associated with: aflatoxin

A

hepatocellular CA

37
Q

CA associated with: vinyl chloride

A

liver angiosarcoma

38
Q

CA associated with: CCl4

A

centrilobular necrosis, fatty liver

39
Q

CA associated with: nitrosamines

A

esophagus, stomch

40
Q

CA associated with: cigarette smoker

A

larynx, lung, kidney, bladde

41
Q

CA associated with: asbestos

A

lung (mesothelioma and bronchogenic CA)

42
Q

CA associated with: arsenic

A

Skin (SCCA) and liver (angiosarcoma)

43
Q

CA associated with: Naphthalene dyes

A

bladder (transitional cell CA)

44
Q

CA associated with: Alkylating agents

45
Q

Tumor marker: PSA

A

prostate cancer

46
Q

Tumor marker: Prostatic acid phosphatas

A

prostate cancer

47
Q

Tumor marker: CEA

A

colorectal and pancreatic cancer, Gastric CA, breast CA

48
Q

Tumor marker: AFP

A

hepatocellular CA, nonseminomatous GCTs

49
Q

Tumor marker: b-HCG

A

hydatidiform mole, choriocarcinoma, gestational trophoblastic tumor

50
Q

Tumor marker: CA-125

A

ovarian, malignant epithelial tumors

51
Q

Tumor marker: S-100

A

melanoma, neural tumors, astrocytomas

52
Q

Tumor marker: Alkaline phosphatase

A

metastases tot he bone, obstructive biliary disease, paget’s disease of the bone

53
Q

Tumor marker: bombesin

A

neutroblastoma, lung and gastric CA

54
Q

Tumor marker: TRAP

A

hairy cell leukemia (B-cell neoplasm)

55
Q

Tumor marker: CA-19-9

A

Pancreatic Adenocarcinoma

Pathology (25 decks)

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