Cancer immunity cycle

Question 1

Step 1

Answer 1

Release of cancer antigens

Question 2

Release of cancer antigens

Answer 2

Antigens released by mutated cancer cells, indicating they’re not healthy cells and the immune system can recognize these antigens

Question 3

Step 2

Answer 3

Cancer antigen presentation
- dendritic cells/APCs

Question 4

Cancer antigen presentation

Answer 4

Cells of the immune system capture released antigens and travel to lymph nodes to find T-cells

Question 5

Step 3

Answer 5

Priming and activation
APCs and T-cells

Question 6

Priming and activation

Answer 6

T-cells are activated by antigens and the immune response is initiated against cancer cells

Question 7

Step 4

Answer 7

Trafficking of T-cells to tumours
Cytotoxic T-cells

Question 8

Trafficking of T-cells to tumours

Answer 8

Activated T-cells move through blood vessels to site of tumour

Question 9

Step 5

Answer 9

Infiltration of T-cells into tumours
Cytotoxic T-cells and endothelial cells

Question 10

Infiltration of T-cells into tumours

Answer 10

T-cells invade and attack tumour

Question 11

Step 6

Answer 11

Recognition of cancer cells by T-cells
Cytotoxic T-cells and cancer cells

Question 12

Step 7

Answer 12

Killing of cancer cells
Immune and cancer cells