Cancer: Genes and Things Flashcards
1
Q
Genetic alteration associated with worse prognosis in rhabdomyosarcoma
A
t(2;13) translocation. Involves the PAX genes 3 and 7
2
Q
Radial margin for Total Mesorectal Excision (TME)
A
<5mm has higher recurrence
tumor within 2mm of margin counts as positive
3
Q
Rate of synchronous lesions in colon cancer
A
3-5%
4
Q
Tumors associated wtih the urachus
A
Rhabdomyosarcoma Transitional cell carcinoma Yolk sac tumor Neuroblastoma (Not Choriocarcinoma) Recommendation is resection of urachal remnant with cuff of bladder wall
5
Q
GIST
A
Stains for c-kit CD117 Give imatinib or sunitinib - 3 years Hematogenous spread (liver not nodes) Stomach 60% Small bowel 30% Higher risk if >5 mitosis, non-gastric, >5cm
6
Q
Gastrinoma triangle
A
Junction of cystic and common bile ducts
Junction of head and neck of pancreas
Junction of 2nd and 3rd portions of duodenum
7
Q
Sarcomas with Lymphatic spread
A
S- Synovial sarcoma C- Clear cell sarcoma A- Angiosarcoma R- Rhabdomyosarcoma E- Embryonal sarcoma
