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PCM1 > Cancer Genes > Flashcards

Cancer Genes Flashcards

1
Q

FGF3

A

Proto Oncogene

Growth Factor

Stomach carcinoma

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2
Q

EGFR (erbb1)

A

Proto Oncogene

Growth Factor Receptor

Lung Adenocarcinoma

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3
Q

Her 2 neu (erbb2)

A

Proto Oncogene

Breast Carcinoma

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4
Q

KRAS

A

Proto Oncogene

Signal transduction protein

Colon & Lung Carcinoma

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5
Q

ABL

A

Proto Oncogene

Tyrosine Kinase

Chronic myeloid leukemia

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6
Q

BRAF

A

Proto Oncogene

Signal transduction protein

Melanoma

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7
Q

N-MYC

A

Proto Oncogene

Transcription Factor

Neuroblastoma

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8
Q

C-MYC

A

Proto Oncogene

Transcription Factor

Burkitt Lymphoma

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9
Q

Cyclin D1

A

Proto Oncogene

Cell Cycle Regulator

Mantle cell lymphoma

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10
Q

CDK4

A

Proto Oncogene

Cell Cycle Regulator

Glioblastoma

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11
Q

APC

A

Tumor Suppressor

Familial: colonic polyps & carcinomas

Sporadic: Stomach, colon, pancreatic carcinomas & melanomas

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12
Q

PTEN

A

Tumor Suppressor

Familial: Cowden Syndrome Benign skin, GI & CNS growth. Breast, endometrial & thyroid carcinoma.

Sporadic: Diverse carcinomas & lymphomas

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13
Q

RB

A

Tumor Suppressor

Familial: retinoblastoma syndrome (retinoblastoma, osteosarcoma).

Sporadic: Retinoblastoma, osteosarcoma, carcinoma of breast, colon, lung.

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14
Q

VHL

A

Tumor Suppressor

Familial: Von Hippel Lindau syndrome (cerebral hemangioblastoma, retinal angioma, renal cell carcinoma).

Sporadic: Renal cell carcinoma

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15
Q

CDH1

A

Tumor Suppressor:

Familial: gastric cancer

Sporadic: Gastric carcinoma, lobular breast carcinoma

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16
Q

TP53

A

Tumor Suppressor

Familial: Li-Fraumeni syndrome

Sporadic: Most human cancers

17
Q

BRCA1,BRCA2

A

Tumor Suppressor

Familial: breast & ovarian carcinoma

Sporadic: rare

18
Q

MSH2, MLH1, MSH6

A

Tumor Suppressor

Familial: Hereditary nonpolyposis colon carcinoma

Sporadic: Colonic & Endometrial carcinoma

19
Q

WT1

A

Tumor Suppressor

Familial: Wilms Tumor

Sporadic: Wilms tumor, certain leukemias

20
Q

PSA

A

Tumor Marker

Prostatic adenocarcinoma

21
Q

CEA

A

Tumor Marker

Colonic, Pancreatic, Breast, Gastric Carcinomas

22
Q

AFP

A

Tumor Marker

Hepatocellular carcinoma

23
Q

hCG

A

Tumor Marker

Trophoblastic Tumors, non seminomatous testicular tumor

24
Q

Calcitonin

A

Tumor Marker

Medullary thyroid carcinoma

25
Q

Catecholamines

A

Tumor Marker

Pheochromocytoma

26
Q

CA 125

A

Tumor Marker

Ovarian carcinoma

27
Q

CA 19.9

A

Tumor Marker

Pancreatic Carcinoma, Colon Carcinoma

PCM1 (7 decks)

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