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PCM1 > Autacoids > Flashcards

Autacoids Flashcards

1
Q

Chlorpheniramine

A

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

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2
Q

Cyclizine

A

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

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3
Q

Diphenhydramine

A

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

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4
Q

Dimenhydrinate

A

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

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5
Q

Hydroxyzine

A

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

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6
Q

Meclizine

A

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

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7
Q

Promethazine

A

1st Gen H1 receptor antagonist

Allergic rhinitis & utricaria, motion sickness, sedative.

AE: sedation, dry mouth.

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8
Q

Fexofenadine

A

2nd Gen H1 receptor antagonist

Allergic rhinitis & utricaria

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9
Q

Loratidine

A

2nd Gen H1 receptor antagonist

Allergic rhinitis & utricaria

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10
Q

Cetirizine

A

2nd Gen H1 receptor antagonist

Allergic rhinitis & utricaria

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11
Q

Cimetidine

A

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

Specific to Cimetidine: anti-androgenic effects, CP450 inhibition.

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12
Q

Ranitidine

A

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

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13
Q

Famotidine

A

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

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14
Q

Nizatidine

A

H2 receptor antagonist

Reduce gastric acid secretion. Treat ulcers, GERD

AE: headache, dizziness, diarrhea, constipation, muscle pain, confusion, hallucinations

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15
Q

Cromolyn

A

Histamine Release Inhibitor

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16
Q

Nedocromil

A

Histamine Release Inhibitor

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17
Q

Sumatriptan

A

5-HT 1D/1B receptor agonist

First line for acute severe migraine attacks.

Contraindicated in patients with CAD or angina due to coronary vasospasm.

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18
Q

Metoclopramide

A

5-HT4 receptor agonist

Prokinetic (helps poop), anti-emetic

AE: Somnolence, nervousness, dystonia. Rarely: extrapyramidal effects.

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19
Q

Cisapride

A

5-HT4 receptor agonist

Prokinetic (helps poop)

No longer available due to severe cardiac AE.

20
Q

Cyproheptadine

A

5-HT2 receptor antagonist + H1 antagonist

Treat allergic rhinitis, vasomotor rhinitis, manage serotonin syndrome

21
Q

Ondansetron

A

5-HT3 receptor antagonist

Anti-emetic. Used for nausea & vomiting associated with chemotherapy.

22
Q

Ergotamine

A

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat migraine pain.

23
Q

Dihydroergotamine

A

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat migraine pain.

24
Q

Bromocriptine

A

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat prolactinemia.

25
Q

Cabergoline

A

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat prolactinemia.

26
Q

Ergonovine

A

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat post-partum hemorrhage & diagnose variant angina via provocative test.

27
Q

Methylergonovine

A

Ergot Alkaloid

Agonist, partial agonist, antagonist at alpha adrenoreceptors & 5-HT receptors.

Used to treat post-partum hemorrhage.

28
Q

Misoprostol

A

Eicosanoid (PGE1 analog)

Peptic ulcer prevention. Abortifacent with mifepristone or methotrexate.

29
Q

Dinoprostone

A

Eicosanoid (PGE2)

Ripen cervix near term. Abortifacent.

30
Q

Alprostadil

A

Eicosanoid (PGE1)

Maintain ductus arteriosus. Treat impotence.

31
Q

Epoprostenol

A

Eicosanoid (PGI2)

Treat severe pulmonary hypertension. Prevent platelet aggregation in dialysis machines.

32
Q

Latanoprost

A

Eicosanoid (PGF2a derivative)

Treat glaucoma.

33
Q

Zileuton

A

Leukotriene inhibitor

Inhibits 5-lypoxygenase

34
Q

Zafirlukast

A

Leukotriene inhibitor

LTD4 receptor antagonist

35
Q

Montelukast

A

Leukotriene inhibitor

LTD4 receptor antagonist

36
Q

Aspirin

A

Irreversible nonselective COX inhibitor

Prototype salicylate. Treat Kawasaki in pediatrics, prophylaxis of colon cancer.

Contraindicated for gout.

37
Q

Diclofenac

A

Nonselective COX inhibitor

38
Q

Ibuprofen

A

Nonselective COX inhibitor

39
Q

Indomethacin

A

Nonselective COX inhibitor

DOC for closure of ductus arteriosus in premature infants. NSAID of choice to treat acute gout attacks.

40
Q

Ketorolac

A

Nonselective COX inhibitor

41
Q

Naproxen

A

Nonselective COX inhibitor

Least cardiac toxicity of any NSAID

42
Q

Piroxicam

A

Nonselective COX inhibitor

43
Q

Celecoxib

A

COX-2 selective inhibitor

44
Q

Meloxicam

A

COX-2 selective inhibitor

Less selective than Celecoxib and therefore safer for heart

45
Q

Acetaminophen

A

Weak COX-1 and 2 inhibitor

No significant anti-inflammatory or anti-platelet effects

PCM1 (7 decks)

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