Cancer Drugs

Question 1

Inhibition of Topoisomerases

Answer 1

Camptothecin (TOP 1)

Etoposide (TOP 2)

Question 2

BRCA Targetting

Answer 2

• Can be due to Epigenetic silencing or indels
• Gives probel with Homologous Rejoining
• Oliparib: Targets PARP

Question 3

Preventing RNA synthesis

Answer 3

• Antinomyocin D: Binds Ds DNA

Question 4

Preventing Aberrant EGFR signalling - Inhibits ErbB2

Answer 4

• Omnitarg: Disrupts persistent dimerisation of RTKs

Question 5

RAF or BRAF inhibitor

Answer 5

• Vemurafinib: binds RAF kinase active site

Question 6

Cyclin Inhibitors

Answer 6

• Small molecule Inhibitors

Question 7

Brc-ABL Fusion

Answer 7

• Translocation

- Imatinib

Question 8

mTOR

Answer 8

Rapamycin Inhibits MTOR effects downstream of AKT

Question 9

SAC

Answer 9

Mitotic Spindle Arrest: SAC / Aurora inhibitors

Question 10

Telomeres

Answer 10

Telomerase Inhibitors

Question 11

Apoptosis (inhibit oncogenes/ anti-apoptotic proteins)

Answer 11

• BH3 Mimetics target BCL-2

- SMAC Mimetics target IAPS

Question 12

Apoptosis (help tumour suppressors/apoptotic proteins)

Answer 12

• Activate P53

- trigger BH3 and Caspase activation

Question 13

Angiogenesis

Answer 13

• Avastin, aka Bevacizumab –> Target VEGF